Navigation Links
New strategy for stimulating neurogenesis may lead to drugs to improve cognition and mood
Date:4/3/2011

NEW YORK (April 3, 2011) Researchers at Columbia University Medical Center have developed a new way to stimulate neuron production in the adult mouse brain, demonstrating that neurons acquired in the brain's hippocampus during adulthood improve certain cognitive functions.

In recent years, scientists have been exploring whether stimulating neurogenesis (the formation of new neurons) in the adult brain has a beneficial effect on cognition or mood. Until now, studies have relied on interventions, such as exercise and enriched environments, that affect numerous other processes in the brain in addition to increasing adult hippocampal neurogenesis.

The research, led by Ren Hen, PhD, professor of Neuroscience and Pharmacology, in the Departments of Neuroscience and Psychiatry at Columbia University and the New York State Psychiatric Institute, appears in the Advance Online Publication of the journal Nature. Amar Sahay, PhD, a postdoctoral fellow, is the lead author on the study.

After boosting the number of neurons in the hippocampus, an area of the brain involved in memory and mood, the researchers tested the mice in both learning and mood-related tasks and looked for changes in behavior. The researchers found specific effects on learning tasks that involve a process called pattern separation, which is the ability to distinguish between similar places, events and experiences.

"This process is crucial for learning because it enables us to know whether something is familiar or novel," said Dr. Hen. "If it is familiar, you move on to the next bit of information; if it's novel, you want to be able to recognize that it's new and give it meaning. These mice, with just more adult-born neurons, and no other changes in the brain, basically learn better in tasks where they have to discriminate between similar contexts."

Earlier strategies for manipulating neurogenesis, according to the investigators, were broader and less s
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Economics and evolution help scientists identify new strategy to control antibiotic resistance
2. Study shows new treatment strategy effective for certain lung cancers
3. H1N1 pandemic points to vaccine strategy for multiple flu strains
4. Canadian marine biodiversity scientists forging strategy for sustainable ocean use
5. New insect birth control strategy zaps cotton pests
6. Frost & Sullivan Honours Fingerprint Cards AB with Product Line Strategy Award
7. A strategy to fix a broken heart
8. UM School of Medicine scientists develop new strategy that may improve cognition
9. Molecular discovery suggests new strategy to fight cancer drug resistance
10. Scientists call for a new strategy for polar ocean observation
11. Flus evolution strategy strikes perfect balance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... study the proteins that let nerve cells send out ... upon a biological tactic that may offer a new ... safe and environmentally responsible way. , Their findingthat ... species and harmless for a closely related onesuggests that ... harming beneficial species like bees. A summary of the ...
(Date:7/10/2014)... Albuquerque, and other major cities in New Mexico, nearly ... municipal wastewater rather than precious potable water supplies. Across ... of all golf courses receive treated effluent. Reusing the ... Additionally, golf courses and homeowners alike fertilize their lawns ... is nitrate. A New Mexico State University turfgrass expert ...
(Date:7/10/2014)...  Pomerantz LLP has filed a class action ... "Company")(NYSE-MKT: PVCT) and certain of its officers.  The ... Middle District of Tennessee , ... consisting of all persons or entities who purchased ... 2013 and May 22, 2014, both dates inclusive ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3'Tailored' water -- the latest in lawn care 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... April issue of the Journal of the American ... eating plans; dietary quality among children; and relationships between ... Increased Risk of Eating Disorders , While vegetarians tend ... non-vegetarians to be overweight or obese, they may be ...
... the Richard King Trainee Award. This award was instituted last ... to encourage ABMG trainees in their careers and to foster ... year the editorial board will review all articles published in ... or corresponding author during that year. The manuscript felt to ...
... Being able to accurately predict how a given ... non-responsive tumors the burden of undergoing toxic and ultimately ... a patient,s cancer-causing genetic lesions are contributing to drug ... Researchers led by Professor Scott Lowe, Ph.D., ...
Cached Biology News:News from the April 2009 Journal of the American Dietetic Association 2Jonathan Berg, M.D., Ph.D. awarded Richard King Trainee Award for Best in Genetics in Medicine 2CSHL team develops mouse models of leukemia that predict response to chemotherapy 2CSHL team develops mouse models of leukemia that predict response to chemotherapy 3CSHL team develops mouse models of leukemia that predict response to chemotherapy 4
(Date:7/10/2014)... July 10, 2014 EvoDerma ’s NOOME ... This rejuvenating device now comes with a second treatment cup ... time. , The new cup is thinner on the edges ... to target rough, thin and uneven surfaces on the face, ... for a stimulating treatment on areas such as the cheeks ...
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
(Date:7/10/2014)... 10, 2014  Kainos Capital, a firm specializing in ... that it has acquired the Slim-Fast brand from Unilever. ... Terms of the transaction were not disclosed. ... business that markets ready-to-drink shakes, powders, bars and snacks ... and in the United Kingdom ...
(Date:7/10/2014)... 10, 2014 Research and Markets ( ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid ... report to their offering. ... of photonic integration traces its roots in the ... of photonic integration went unexplored and unfulfilled for ...
Breaking Biology Technology:Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Kainos Capital Acquires Slim-Fast From Unilever 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2
... 2003 , , MADISON, Wis. -- Forty-five ... the 2004 Technology Awards Banquet for receiving over $24.6 ... held in conjunction with the Wisconsin Entrepreneurs? Conference ... small business innovation research (SBIR) and advanced technology program ...
... MILWAUKEE Despite the encroachment of wireless technology, broadband ... popular with business and home users, according to Dan ... Warner Cable . , ,In his keynote address Wednesday ... what he sees as the future of broadband, mentioning ...
... has published the first-ever magazine about Wisconsins life ... research base, technology-transfer process, company creation, quality of ... joins Chicago, Wisconsin and Minneapolis-St. Paul. , ,The ... from Life Sciences: Wisconsin The Smart Choice, ...
Cached Biology Technology:Wisconsin technology companies awarded over $24 million in government funding 2Wisconsin technology companies awarded over $24 million in government funding 3Wisconsin technology companies awarded over $24 million in government funding 4Future of cable, wireless shown off at ITEC Milwaukee 2Future of cable, wireless shown off at ITEC Milwaukee 3Future of cable, wireless shown off at ITEC Milwaukee 4Life Sciences: Wisconsin- The Smart Choice 2Life Sciences: Wisconsin- The Smart Choice 3Life Sciences: Wisconsin- The Smart Choice 4Life Sciences: Wisconsin- The Smart Choice 5Life Sciences: Wisconsin- The Smart Choice 6Life Sciences: Wisconsin- The Smart Choice 7
... workstation is the simplest, easiest-to-use system ever ... liquid handling capabilities,into their labs, or groups ... routine applications on a separate instrument. Plate-handling ... even when you have thousands of ...
... has generated hybridomas against a large ... initiation, you are provided with personalized ... cell lines developed by Covance remain ... typical hybridoma development project has four ...
... cDNA normalization is essential for ... using high-throughput approaches, such as EST ... Most normalization methods are not well ... cDNA. The Evrogen TRIMMER kit, though, ...
... ENGENISTM (Entire Gene/cDNA or Isolated Sequence) siRNA ... quantitative approach for evaluation of a potential ... an efficient target for RNA interference (RNAi). ... not perfect, leaving the probability of selected ...
Biology Products: