Navigation Links
New strategy for inhibiting virus replication
Date:8/14/2009

B>

A cell contains numerous variants of cyclophilins that are inhibited by cyclosporin and cyclosporin derivatives. The research team from Heidelberg analyzed liver cells to determine which cyclophilin is critical for hepatitis C virus replication. They found that only blocking cyclophilin A leads complete inhibition of virus replication and this cyclophilin is also the target of DEBIO-025.

Two complementary effects are responsible for the inhibition of hepatitis C virus replication: cyclophilin A is required both for the formation of the viral replication machinery and for the activity of a viral enzyme that is essential for the assembly of infectious virus particles. Inhibiting cyclophilin A with DEBIO-025 thus blocks hepatitis C virus replication from two different sides. By contrast, blocking cyclophilin B had no effect.

"The therapeutic potential of inhibiting cellular factors essential for virus replication has thus far hardly been tapped," explains Professor Bartenschlager. "But this approach has the major advantage that resistance arises less frequently and to a lesser extent in comparison to therapies directly targeting viral factors."


'/>"/>

Contact: Dr. Ralf Bartenschlager
Ralf_Bartenschlager@med.uni-heidelberg.de
062-215-64569
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2

Related biology news :

1. A combined tooth-venom arsenal revealed as key to Komodo dragons hunting strategy
2. New therapeutic strategy could target toxic protein in most patients with Huntingtons disease
3. Therapeutic hypothermia is promising strategy to minimize tissue damage
4. RNA research strategy for Europe takes shape
5. Hope for a rabies eradication strategy in Africa
6. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
7. GUMC researchers hone in on new strategy to treat common infection
8. Effects of anthropogenic sound on marine mammals -- a research strategy
9. Scientists uncover Ebola cell-invasion strategy
10. New study raises concerns about proposed mitigation strategy for marine bycatch
11. Novel therapeutic strategy for colon cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... , March 5, 2015 In ... percent of companies already using these solutions and 42 percent ... Of the latter, approximately 25 percent of the companies will ... While the majority of companies in the region are ... that the hybrid model will command significant attention in the ...
(Date:3/4/2015)... DUBLIN , Mar. 04, 2015 Research ... announced the addition of the "Global Biometrics ... their offering. The market for biometric ... CAGR of around 14% till 2020 ... will be increasing security needs, government projects and ...
(Date:3/3/2015)... , March 3, 2015 Cryoport, ... of advanced cryogenic logistics solutions for the ... stem cells, cell lines, clinical research organizations, ... today announced the expansion of its relationship ... ("Fred Hutch") Clinical Research Division with ...
Breaking Biology News(10 mins):Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 2Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 3Two of Every Three Brazilian Companies will have Invested in Cloud by 2015, Finds Frost & Sullivan 4Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
... landmark genetic study has identified multiple genes linked to ... disease that affects an estimated 1.4 million Americans. ... brain and blood and occurs in about 31 out ... likely than men to develop the condition, which is ...
... from the January issue of Mayo Clinic Proceedings include ... workplace drug screening and the safety and effectiveness of ... Examine the Effect of Antioxidant Supplements on Cancer ... cancer and deaths related to cancer? Thats a question ...
... The National Academy of Sciences, Sackler Colloquium series ... These networks represent the genomic program for ... cell types. The meeting will focus on ... early embryonic development; gene networks later developmental processes; ...
Cached Biology News:Steps toward Stopping Autoimmune Disease 2Mayo Clinic Proceedings January tip sheet 2Mayo Clinic Proceedings January tip sheet 3
(Date:3/5/2015)... , March 5, 2015  DuPont (NYSE: ... Aviation, Transportation and Industrials Conference held today in ... Matthew L. Trerotola discussed strategy, progress and ... segments for DuPont.  Strengthening and growing the company,s leading ... three areas of strategic priority for DuPont. ...
(Date:3/5/2015)... -- Twelve patients today are preparing to participate in a ... Pacific Medical Center (CPMC), a Sutter Health affiliate. ... the largest single-center kidney paired donation chain conducted on ... 44-year history of the CPMC Transplant Center. The two-day ... donor who did not have a specific recipient in ...
(Date:3/5/2015)... March 5, 2015   HX360 today announced ... the HX360 Innovation Challenge competition. These companies, ... to be chosen as one of four finalists to ... health system executives and venture capitalists during the Innovation ... takes place at the 2015 HIMSS Annual Conference & ...
(Date:3/5/2015)... York (PRWEB) March 05, 2015 LifeCell ... to be able to get an Advanced Semen Analysis ... stress, blaming and guessing are all risk factors for ... the woman is the source of the infertility. Infertility ... LifeCell Dx has the simplest, least complicated and ...
Breaking Biology Technology:DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 2DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 3DuPont Leader Highlights Strategy, Progress and Plans to Accelerate Growth in Advanced Materials and Discusses Near-Term Outlook 4Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 2Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 3Altruistic donor starts large West Coast single-center kidney paired donation at CPMC 4HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4LifeCell Dx Offers New Option to Veterans with Infertility 2LifeCell Dx Offers New Option to Veterans with Infertility 3
... trials show that Emulin(TM), a plant-based extract, is better than metformin, ... in human beings. , ... Winter Haven, FL (PRWEB) ... blood sugar levels in Type 2 diabetics better than a leading ...
... Covers Development of Gene Expression Signatures Derived by ... as Molecular Test of Responsiveness to Current Treatments, ... /PRNewswire-FirstCall/,-- Transgenomic (OTC Bulletin Board: TBIO) today announced ... diagnostic test which will guide,clinicians in their choice ...
... Technology Targets Tumors with Precise Image-Guided IMRT to Spare Healthy ... ... ALTO, Calif., Sept. 16 Doctors at cancer,treatment centers in ... neck cancer using RapidArc(TM) radiotherapy technology from Varian,Medical Systems (NYSE: ...
Cached Biology Technology:Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™ 2Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 2Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 3Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 4Doctors in the US and Netherlands Using Fast RapidArc Radiotherapy Technology to Help Fight Cancer are Now Treating Tumors of the Head and Neck 2Doctors in the US and Netherlands Using Fast RapidArc Radiotherapy Technology to Help Fight Cancer are Now Treating Tumors of the Head and Neck 3
Direct ELISA Assay Diluent, 100 mL...
Assay Diluent Trial Pack, 4 x 100 mL...
SpectroQuest single beam 1.8nm UV/Vis spectrophotometer; stand-alone unit...
...
Biology Products: