Navigation Links
New strategy could lead to dose reduction in X-ray imaging
Date:11/22/2011

Athens, Ga. For more than a century, the use of X-rays has been a prime diagnostic tool when it comes to human health. As it turns out, X-rays also are a crucial component for studying and understanding molecules, and a new approach -- just published by researchers at the University of Georgia -- may dramatically improve what researchers can learn using the technique.

One of the primary ways scientists can understand molecules is to bombard their crystalline forms with X-ray beams. This allows a crystallographer to discover many things about the molecule, from the arrangement of atoms to the position of chemical bonds. Thus, the techniques of X-ray crystallography have been central to numerous important scientific discoveries in many fields.

Now, a team led by B.C. Wang, Ramsey-Georgia Research Alliance Eminent Scholar in Structural Biology at UGA, has shown for the first time that by using multiple data sets, each under-exposed simultaneously, one can produce a composite data set that may give three to five times better signal levels than standard techniques for structural analysis. This new technique is particularly better than standard procedures when it comes to studying large molecules, many of which are important in drug development and other important processes.

"When compared to crystals of small molecules, macromolecular crystals diffract X-rays poorly and usually tend to have a much shorter lifetime in the X-ray beam," said Wang. "So a macromolecular crystal can only withstand a certain amount of X-ray dose before it is destroyed as a result of radiation damage. Obtaining accurate and complete diffraction data sets of these crystals is very important."

Strikingly, the new procedure used by the Wang team could be adapted for use with X-ray techniques in studying human health. This could eventually mean that doctors utilizing it could get more information on a patient while using a lower X-ray dose. That, however, is
'/>"/>

Contact: B.C. Wang
wang@bcl1.bmb.uga.edu
706-542-1747
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rudolph the red-nosed reindeers cooling strategy revealed
2. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
3. BGI develops new strategy to uncover structural variations of human genomes
4. Bacterial attack strategy uses special delivery of toxic proteins
5. Purdue biologists identify new strategy used by bacteria during infection
6. Study suggests new strategy to prevent infertility, birth defects
7. Nuclear waste requires cradle-to-grave strategy
8. U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering"
9. Global strategy for plant conservation conference to take place at the Missouri Botanical Garden
10. New strategy to combat cystitis
11. Study finds greenhouse gas reduction strategy may be safe for soil animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 31, 2015  Elephant Talk Communications Corp. (NYSE MKT: ... of Software Defined Network Architecture (ET Software DNA® 2.0) ... of approximately $20.4 million for the year ended December ... for the year ended December 31, 2013. ... had completed its multi-year transition away from its legacy ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
(Date:3/24/2015)... WASHINGTON , March 24, 2015   NexID ... applications with critical security-authentication needs, today announced the beginning ... fake-finger-detection (FFD) solution. The company, based in ... announcement at the three-day Connect:ID Expo, which began here ... NexID said version 2.0 of its SDK boosts ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... MIAMI -- The ability of marine reserves to replenish ... their ability to benefit shallow-water communities to thrive remains ... of Miami (UM) Rosenstiel School of Marine & Atmospheric ... has translated into positive impacts on coral communities in ...
... Industries LLC announced today that Oligonol, manufactured by Amino ... a recipient of the SupplySide West 2011 Scientific Excellent ... on Wednesday, October 12, 2011 in Las Vegas at ... technology providers with new ingredients or technologies, as well ...
... fish,s personality may determine how it is captured. This ... evolutionary and ecological consequences for affected fish populations, as ... Anglers fishing near rocky outcrops or in areas of ... catch timid fish, while those fishing in open water ...
Cached Biology News: New study of Glover's Reef challenges whether corals will benefit from Marine Reserves' protection 2Oligonol receives Supplyside West 2011 scientific Excellence Award 2
(Date:4/28/2015)... Spartan Bioscience today announced that Paul ... by the Ottawa Chamber of Commerce as one of ... selected from over 240 applicants based on his business ... Spartan, Dr. Lem founded Plexagen Diagnostics, and also served ... a Medical Degree from the University of Ottawa, and ...
(Date:4/27/2015)... , April 27, 2015  For about a ... is their ability to utilize and catabolize glucose ... cancer cells is called the ,Warburg phenomenon", that ... of high oxygen presence, leading to enhanced lactate ... cells still choose glucose fermentation. A variety of ...
(Date:4/27/2015)... Diego, Calif. (PRWEB) April 27, 2015 ... of drug and chemical toxicity carries implications for advancing ... speaker April 28 at National University , the ... and presentation by Dr. Hanzlik, a professor at the ... drug metabolism and drug design, starts at 5 p.m. ...
(Date:4/27/2015)... BRUNSWICK, New Jersey , 27 ... société de découverte médicamenteuse spécialisée dans ... antibiotiques destinés à soigner les infections ... aujourd,hui la présentation de données prouvant ... majeur, le TXA709, dans la lutte ...
Breaking Biology Technology:Spartan Bioscience Announces Paul Lem Named Ottawa’s Top 40 Under 40 2Study Indicates Cancer Cells Alter Glucose Metabolism to Enhance Energy Production and Cell Growth 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 2Dr. Robert Hanzlik Discusses Pharmaceutical Testing Models at Event Hosted by National University 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 2TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 4TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 5TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 6
... International Daleco Corporation (Pink Sheets: ILDO) announces its ... joint venture company, ICAP Bio Organic, S. de R.L. ... and proprietary bio-organic catalyst compositions (BOCs) within Central America, Mexico ... renewable energy credit opportunities where available. , SIF ICAP ...
... , BEIJING, Oct. 27 /PRNewswire-Asia/ ... provider of biopharmaceutical products in China, announced today that,it ... vaccine, PANFLU.1, from,China,s Ministry of Industry and Information Technology ... is required to produce an,additional 5.19 million doses of ...
... YORK, Oct. 26 Reportlinker.com announces ... is available in its catalogue. , ... Pipeline Analysis and Competitive Assessment ... , In the nearly 35 ...
Cached Biology Technology:Bio-Organic Catalyst, Inc. Forms Joint Venture With SIF ICAP Mexico S.A. de C.V. as Exclusive Distribution Hub for Central America, Mexico and Caribbean. 2Sinovac Obtains Third H1N1 Vaccine Order from Chinese Central Government 2Sinovac Obtains Third H1N1 Vaccine Order from Chinese Central Government 3Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 2Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 3Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 4Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 5Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 6Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 7Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment 8
TUNEL Apoptosis Detection Kit...
... assay kit measures NOS activity by monitoring ... This assay is simple, sensitive, and specific ... with both crude and purified enzyme preparations. ... for 50 total reactions. Radiolabeled arginine and ...
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Mouse Axl MAb (Clone 175128)...
Biology Products: