Navigation Links
New strategy could lead to dose reduction in X-ray imaging
Date:11/22/2011

Athens, Ga. For more than a century, the use of X-rays has been a prime diagnostic tool when it comes to human health. As it turns out, X-rays also are a crucial component for studying and understanding molecules, and a new approach -- just published by researchers at the University of Georgia -- may dramatically improve what researchers can learn using the technique.

One of the primary ways scientists can understand molecules is to bombard their crystalline forms with X-ray beams. This allows a crystallographer to discover many things about the molecule, from the arrangement of atoms to the position of chemical bonds. Thus, the techniques of X-ray crystallography have been central to numerous important scientific discoveries in many fields.

Now, a team led by B.C. Wang, Ramsey-Georgia Research Alliance Eminent Scholar in Structural Biology at UGA, has shown for the first time that by using multiple data sets, each under-exposed simultaneously, one can produce a composite data set that may give three to five times better signal levels than standard techniques for structural analysis. This new technique is particularly better than standard procedures when it comes to studying large molecules, many of which are important in drug development and other important processes.

"When compared to crystals of small molecules, macromolecular crystals diffract X-rays poorly and usually tend to have a much shorter lifetime in the X-ray beam," said Wang. "So a macromolecular crystal can only withstand a certain amount of X-ray dose before it is destroyed as a result of radiation damage. Obtaining accurate and complete diffraction data sets of these crystals is very important."

Strikingly, the new procedure used by the Wang team could be adapted for use with X-ray techniques in studying human health. This could eventually mean that doctors utilizing it could get more information on a patient while using a lower X-ray dose. That, however, is
'/>"/>

Contact: B.C. Wang
wang@bcl1.bmb.uga.edu
706-542-1747
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Rudolph the red-nosed reindeers cooling strategy revealed
2. Powerful antibody-based strategy suggests a new therapeutic approach to diabetes and obesity
3. BGI develops new strategy to uncover structural variations of human genomes
4. Bacterial attack strategy uses special delivery of toxic proteins
5. Purdue biologists identify new strategy used by bacteria during infection
6. Study suggests new strategy to prevent infertility, birth defects
7. Nuclear waste requires cradle-to-grave strategy
8. U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering"
9. Global strategy for plant conservation conference to take place at the Missouri Botanical Garden
10. New strategy to combat cystitis
11. Study finds greenhouse gas reduction strategy may be safe for soil animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... stretch them, twist them, fold them: modern materials that ... potential, whether as artificial skin or electronic paper. , ... a challenge but a new way of working with ... a game-changer. , Previous success in the field ... use of precious gold and silver nanowires. , ...
(Date:8/28/2014)... of marine protected areas is needed to protect fish ... investigators from the Wildlife Conservation Society and other organizations, ... the largest numbers of species, often at the expense ... functions. , Many vital ecological functions of ... are food for millions of people. This study ...
(Date:8/28/2014)... Researchers at the University of Minnesota have developed ... to be used for muscle regeneration research as well ... FSHD. , The research is published in the current ... There is no treatment for FSHD, which is thought ... muscular dystrophy. FSHD is an unusual genetic disorder because, ...
Breaking Biology News(10 mins):Copper shines as flexible conductor 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2UMN researchers find animal model for understudied type of muscular dystrophy 2
... BLOOMINGTON, Ind. -- Two recently diverged populations of a ... contribute to the reproductive isolation that accompanies the origin ... of organic compounds present in the preen oils of ... Ecology . "There,s so much we don,t know ...
... Age and gender play a major role in how ... 20-to-64-year-olds. Published in the journal Psychophysiology , the investigation ... the Montreal Heart Institute in collaboration with colleagues from the ... findings suggest that women who are more defensive are at ...
... University of Western Ontario finds the sauces you use when ... benefits. The research, led by Western biology and psychology ... than just tasty sauces they can also provide a ... Mark Bernards and Christopher Guglielmo in Western,s department of biology. ...
Cached Biology News:Could smell play a role in the origin of new bird species? 2Could smell play a role in the origin of new bird species? 3Men and women respond differently to stress 2Spice up your health this barbecue season 2
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
(Date:8/28/2014)... --  SunTrust Robinson Humphrey (STRH) today announced ... equity research team in biotechnology and oilfield services.  ... research demonstrates our commitment to providing our valued ... investment decision making," said Biff Woodruff , ... make significant investments in differentiated content at a ...
(Date:8/28/2014)... Woodstock, Vt. (PRWEB) August 28, 2014 ... microbiology testing around the world is available from ... industrial diagnostics companies. “ Industrial Microbiology Market Review, ... the Industrial Market ” (IMMR—4) tracks and compares ... in in North America, Europe and Asia, and ...
(Date:8/27/2014)... Lake City, Utah (PRWEB) August 27, 2014 ... construction that will expand its current Salt Lake City ... currently underway outside of Utah to ultimately create 1,000 ... next 20 years. , “Utah is home to ... of whom can be credited with Varian’s success in ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3
... LPBP Inc. (LPBP) - At the request of,the ... of,the President and Chief Executive Officer and of ... of its interim filings for the quarters,ended January ... were,previously filed. The re-filing of these Certificates is ...
... Profitability, HARBIN, China, Aug. 15 /Xinhua-PRNewswire-FirstCall/ -- ... Board: CKGT), a,vertically integrated grower, developer, manufacturer and ... China, announced today record,second quarter results for the ... of $5.0 million, a 34.9% increase compared to ...
... 15 Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ... and six months ended June 30, 2008., ... program for,CPP-109," stated Patrick J. McEnany, Catalyst,s Chief ... dosing subjects in our U.S.,Phase II clinical trials ...
Cached Biology Technology:China Kangtai Cactus Biotech Announces Record Second Quarter Results 2China Kangtai Cactus Biotech Announces Record Second Quarter Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 2Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 4Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 5
... GenomePlex Single Cell Whole Genome Amplification ... on random fragmentation of genomic DNA ... fragments to PCR-amplifiable library molecules flanked ... achieved by PCR amplification of the ...
...
From formula-fed bovine calves Sterile, Cell culture tested...
Collected at a certified USDA establishment located within the United States. All final processing is done by Quad Five employees....
Biology Products: