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New stem cell research points to early indicators of schizophrenia
Date:5/13/2014

e realized they weren't mature neurons but only as old as neurons in the first trimester," Brennand says. "So we weren't studying schizophrenia but the things that go wrong a long time before patients actually get sick."

Interestingly, the study also found that antipsychotic medication such as clozapine and loxapine did not improve migration in NPCs (in particular, loxapine actually worsened migration in these cells).

"That was an experiment that gave the opposite results from what we were expecting," says Brennand. "Though in hindsight, using drugs that treat symptoms might not be helpful in trying to prevent the disease."

The next steps to this work will be to increase the sample size to a broader range of patients and to look at hundreds or thousands of patient samples, says Brennand.


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Contact: Chris Emery
cemery@salk.edu
858-453-4100
Salk Institute
Source:Eurekalert  

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