Navigation Links
New stem cell research could reduce number of animal experiments
Date:8/4/2009

Researchers from the University of Bath are embarking on a project to use stem cell technology that could reduce the number of animal experiments used to study conditions such as motor neurone disease.

Dr Vasanta Subramanian, from the University's Department of Biology & Biochemistry, will be developing a technique using human stem cells to study this debilitating neurological disease, greatly reducing the number of animals used in research.

Stem cells are the precursor cells that are able to develop into more specialised cells and tissues such as neurones or skin cells.

Whilst previously most stem cells were derived from embryos, this new research project will instead use Induced Pluripotent Stem cells (iPS cells) which are made from skin cells from adults.

Dr Subramanian has been awarded a major three year grant by the National Centre for Replacement, Refinement & Reduction of Animals in Research (NC3Rs) to study ALS, a form of motor neurone disease in which the nerve cells that control the muscles die.

This currently incurable condition causes patients to lose movement in muscles, affecting breathing and eventually causing death.

Dr Subramanian will be making iPS cells from the skin cells of patients suffering from ALS to study the genes that are thought to cause the disease.

She said: "These are exciting times for stem cell research and there is tremendous potential in the iPS cell technology both for medical applications and in basic biology.

"This technology will not only help understand the mechanisms underlying the disease, but will also reduce the numbers of animals used in research.

"There is a real need to develop alternative methods for studying these diseases that are more robust and better simulate how the disease develops in humans."

The grant will fund a teaching replacement for Dr Subramanian, allowing her to focus on her research, and a research assistant to work on the project. It will also fund a state-of-the-art high power microscope that will allow the researchers to observe the movements and growth of neurones in real time.

The project is one of 13 receiving a share of a 4.5 million fund from the NC3Rs.

Dr Vicky Robinson, chief executive of the NC3Rs, said: "If we are to reduce animal use and at the same time continue to develop new treatments for diseases then we must engage the best minds and harness the best science and technology in this endeavour.

"That is what we are doing with the 4.5 million in 13 new research projects that the NC3Rs is investing in. We are really pleased to be giving grants to scientists who are trying to develop treatments in major areas of concern such as cancer, motor neurone disease and Alzheimer's disease.

"If they can do this, and reduce their reliance on animal use then this has to be good news."


'/>"/>

Contact: Vicky Just
v.j.just@bath.ac.uk
44-122-538-6883
University of Bath
Source:Eurekalert  

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New stem cell research could reduce number of animal experiments
(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/27/2017)... 2017  Catholic Health Services (CHS) has been ... (HIMSS) Analytics for achieving Stage 6 on the ... In addition, CHS previously earned a place in ... electronic medical record (EMR). "HIMSS Analytics ... EMR usage in an outpatient setting.  This recognition ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, ... in analytical testing are being attributed to new regulatory requirements for all new ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... any gene in its endogenous context, enabling overexpression experiments and avoiding the use ... with small RNA guides is transformative for performing systematic gain-of-function studies. , ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
Breaking Biology Technology: