Navigation Links
New stage in fighting pancreatic cancer
Date:1/3/2012

A promising line of attack against pancreatitis and pancreatic cancer is to be explored further at Cardiff University, thanks to substantial new funding from the Medical Research Council (MRC).

Pancreatitis can develop when the enzymes needed for digestion turn on the pancreas itself. Chronic pancreatitis increases the risk of pancreatic cancer, which has the lowest five-year survival rate of all common cancers in the UK. High alcohol intake and gallstones are the most common causes of pancreatitis.

Last year, Professor Ole Petersen and colleagues at Cardiff University's School of Biosciences, revealed that a protein call calmodulin could protect the pancreas against the effects of alcohol. In cells without calmodulin, alcohol speeds up a chain reaction causing cells to self-destruct, leading to pancreatitis and potentially to pancreatic cancer. The team also discovered a calcium-like molecule which could boost the pancreas' natural protection against digestive enzymes. These breakthroughs have just been highlighted in the MRC's review of the most significant developments of 2011.

Now Professor Petersen's team has secured a 2M MRC Programme Grant to investigate the potential of the calcium-like molecule further. Over the next five years, they will test its ability to protect against enzymes in a number of circumstances known to trigger pancreatitis. The team will also investigate special cells in the pancreas called stellate cells. Little is known about stellate cells but they could be the link between chronic pancreatitis and the development of pancreatic cancer.

Professor Petersen has also has his MRC Professorship renewed the only post of its kind in Wales. He said: "These are extremely complex molecular processes but we believe they are crucial to our understanding of these painful and distressing diseases. We aim to identify ways of controlling these processes to help prevent and treat acute pancreatitis. We also hope to build on our existing knowledge to better understand stellate cells and block the onset of pancreatic cancer. We are extremely grateful to the MRC for their support and encouragement of this promising research avenue."


'/>"/>
Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related biology news :

1. Unknown species and larval stages of extremely long-legged beetles discovered by DNA test
2. Researchers characterize biomechanics of ovarian cells according to phenotype at stages of cancer
3. String blossom thinner proves effective across stages of bloom development
4. Cell Transplantation reports a success in treating end-stage liver disease
5. Active management of the third stage of labor reduces risk of bleeding
6. Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
7. Report: Discovery networks hostage-taking a rare terror event
8. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
9. Aquatic life declines at early stages of urban development
10. Multistage nanovector system provides sustained delivery of siRNA cancer therapeutic in mice
11. Gene therapy sets stage for new treatments for inherited blindness, Penn veterinary researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... MOUNTAIN VIEW, Calif. , Feb. 2, 2016 ... diabetic retinopathy market, Frost & Sullivan recognizes US-based ... North America Frost & Sullivan Award for New ... technology provider in North America ... standard in the rapidly growing diabetic retinopathy market. ...
(Date:1/28/2016)... SYNA ), a leading developer of human interface solutions, today ... --> --> Net revenue ... to the comparable quarter last year to $470.5 million. Net income ... $0.93 per diluted share. --> ... 2016 grew 9 percent over the prior year period to $60.3 ...
(Date:1/22/2016)... , January 22, 2016 /PRNewswire/ ... announced the addition of the  "Global ... their offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... February 11, 2016 , ... Reichert Technologies, which ... today to pursue the highest level of accuracy and quality with the addition ... and the AR5 Refractometer. Accurate, reliable and tough enough for the most ...
(Date:2/10/2016)... BioAmber Inc. (NYSE: BIOA ), a leader in ... Co. Ltd., its partner in the Sarnia ... additional CDN$25 million in the joint venture for 10% ... 40%.  Mitsui will also play a stronger role in ... Sarnia , providing dedicated resources alongside BioAmber,s commercial ...
(Date:2/10/2016)... , Feb. 10, 2016 NX Prenatal Inc., ... proprietary NeXosome® technology for early warning of adverse ... most recent study by Dr. Thomas McElrath ... Society for Maternal Fetal Medicine,s (SMFM) annual meeting held ... th , 2016.  The presentation reported initial positive ...
(Date:2/10/2016)... (NYSE MKT: ISR), a medical technology company and innovator ... treatment of prostate, brain, lung, head and neck and ... second quarter and six months of fiscal 2016, which ... --> Revenue was $1.19 million for ... 31, 2015, a 12% increase compared to $1.07 million ...
Breaking Biology Technology: