Navigation Links
New stage in fighting pancreatic cancer
Date:1/3/2012

A promising line of attack against pancreatitis and pancreatic cancer is to be explored further at Cardiff University, thanks to substantial new funding from the Medical Research Council (MRC).

Pancreatitis can develop when the enzymes needed for digestion turn on the pancreas itself. Chronic pancreatitis increases the risk of pancreatic cancer, which has the lowest five-year survival rate of all common cancers in the UK. High alcohol intake and gallstones are the most common causes of pancreatitis.

Last year, Professor Ole Petersen and colleagues at Cardiff University's School of Biosciences, revealed that a protein call calmodulin could protect the pancreas against the effects of alcohol. In cells without calmodulin, alcohol speeds up a chain reaction causing cells to self-destruct, leading to pancreatitis and potentially to pancreatic cancer. The team also discovered a calcium-like molecule which could boost the pancreas' natural protection against digestive enzymes. These breakthroughs have just been highlighted in the MRC's review of the most significant developments of 2011.

Now Professor Petersen's team has secured a 2M MRC Programme Grant to investigate the potential of the calcium-like molecule further. Over the next five years, they will test its ability to protect against enzymes in a number of circumstances known to trigger pancreatitis. The team will also investigate special cells in the pancreas called stellate cells. Little is known about stellate cells but they could be the link between chronic pancreatitis and the development of pancreatic cancer.

Professor Petersen has also has his MRC Professorship renewed the only post of its kind in Wales. He said: "These are extremely complex molecular processes but we believe they are crucial to our understanding of these painful and distressing diseases. We aim to identify ways of controlling these processes to help prevent and treat acute pancreatitis. We also hope to build on our existing knowledge to better understand stellate cells and block the onset of pancreatic cancer. We are extremely grateful to the MRC for their support and encouragement of this promising research avenue."


'/>"/>
Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related biology news :

1. Unknown species and larval stages of extremely long-legged beetles discovered by DNA test
2. Researchers characterize biomechanics of ovarian cells according to phenotype at stages of cancer
3. String blossom thinner proves effective across stages of bloom development
4. Cell Transplantation reports a success in treating end-stage liver disease
5. Active management of the third stage of labor reduces risk of bleeding
6. Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
7. Report: Discovery networks hostage-taking a rare terror event
8. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
9. Aquatic life declines at early stages of urban development
10. Multistage nanovector system provides sustained delivery of siRNA cancer therapeutic in mice
11. Gene therapy sets stage for new treatments for inherited blindness, Penn veterinary researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Nanomedical Diagnostics, ... development, announces the launch of a new NTA biosensor chip for use with ... study the kinetics of polyhistidine-tagged (His-tagged) molecules quickly and reliably. , “Recombinant ...
(Date:7/18/2017)... Basel, Switzerland (PRWEB) , ... July 18, 2017 ... ... for R&D, today announced that Merck, a leading science and technology company, has ... develop innovative therapeutics for the therapeutic areas of Oncology, Immunology, and Neurodegenerative Diseases. ...
(Date:7/18/2017)... ... July 18, 2017 , ... Blood centers traditionally see a dangerous drop ... summer is a struggle for community blood centers as high schools are out and ... of Commerce is teaming up with the South Texas Blood & Tissue ...
(Date:7/18/2017)... ... July 18, 2017 , ... Recently recognized by CIO ... announces the migration of its flagship cloud-based product Planet Life Cycle – a ... work management system that merges strategic and financial planning with execution. The solution ...
Breaking Biology Technology: