Navigation Links
New stage in fighting pancreatic cancer
Date:1/3/2012

A promising line of attack against pancreatitis and pancreatic cancer is to be explored further at Cardiff University, thanks to substantial new funding from the Medical Research Council (MRC).

Pancreatitis can develop when the enzymes needed for digestion turn on the pancreas itself. Chronic pancreatitis increases the risk of pancreatic cancer, which has the lowest five-year survival rate of all common cancers in the UK. High alcohol intake and gallstones are the most common causes of pancreatitis.

Last year, Professor Ole Petersen and colleagues at Cardiff University's School of Biosciences, revealed that a protein call calmodulin could protect the pancreas against the effects of alcohol. In cells without calmodulin, alcohol speeds up a chain reaction causing cells to self-destruct, leading to pancreatitis and potentially to pancreatic cancer. The team also discovered a calcium-like molecule which could boost the pancreas' natural protection against digestive enzymes. These breakthroughs have just been highlighted in the MRC's review of the most significant developments of 2011.

Now Professor Petersen's team has secured a 2M MRC Programme Grant to investigate the potential of the calcium-like molecule further. Over the next five years, they will test its ability to protect against enzymes in a number of circumstances known to trigger pancreatitis. The team will also investigate special cells in the pancreas called stellate cells. Little is known about stellate cells but they could be the link between chronic pancreatitis and the development of pancreatic cancer.

Professor Petersen has also has his MRC Professorship renewed the only post of its kind in Wales. He said: "These are extremely complex molecular processes but we believe they are crucial to our understanding of these painful and distressing diseases. We aim to identify ways of controlling these processes to help prevent and treat acute pancreatitis. We also hope to build on our existing knowledge to better understand stellate cells and block the onset of pancreatic cancer. We are extremely grateful to the MRC for their support and encouragement of this promising research avenue."


'/>"/>
Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related biology news :

1. Unknown species and larval stages of extremely long-legged beetles discovered by DNA test
2. Researchers characterize biomechanics of ovarian cells according to phenotype at stages of cancer
3. String blossom thinner proves effective across stages of bloom development
4. Cell Transplantation reports a success in treating end-stage liver disease
5. Active management of the third stage of labor reduces risk of bleeding
6. Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
7. Report: Discovery networks hostage-taking a rare terror event
8. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
9. Aquatic life declines at early stages of urban development
10. Multistage nanovector system provides sustained delivery of siRNA cancer therapeutic in mice
11. Gene therapy sets stage for new treatments for inherited blindness, Penn veterinary researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/14/2017)... Feb. 14, 2017  Wake Forest Baptist Medical Center ... new chief executive officer (CEO). Freischlag joins the medical ... D. McConnell , M.D., who last year announced that ... Medical Center, after leading it since 2008.   ... of Wake Forest Baptist,s academic health system, which includes ...
(Date:2/13/2017)... Feb. 13, 2017 Former 9/11 Commission border ... Committee, Janice Kephart of Identity Strategy Partners, ... Donald Trump,s "Executive Order: Protecting the Nation From ... 2017):  "As President Trump,s ,Travel Ban, Executive ... now essentially banned the travel ban, it is important ...
(Date:2/9/2017)... The biomass boiler market report by Transparency Market Research ... in terms of revenue (US$ Mn) based on the ... boilers has been segmented on the basis of feedstock ... based on feedstock type, has been segmented into woody ... urban residues, and others. On the basis of product ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... Feb. 27, 2017 AcelRx Pharmaceuticals, Inc. ... the development and commercialization of innovative therapies for ... the U.S. Food and Drug Administration (FDA) has ... section 505(b)(2) for DSUVIA™ (formerly ARX-04) (sufentanil sublingual ... with moderate-to-severe acute pain in a medically supervised ...
(Date:2/27/2017)... Fluxion Biosciences announced today that Genetracer Biotech ... appointed as a Certified Service Provider for Fluxion,s IsoFlux ... used in Genetracer Biotech,s novel liquid biopsy workflows for ... with plans to move to other cancers as additional ... System to isolate, recover, and analyze CTCs (circulating tumor ...
(Date:2/26/2017)... ... ... Lowe is a well recognized television personality, so it seems natural he would host ... to the American public and important to society at large. An upcoming episode will ... world for a few years. , The climate and how we relate to it ...
(Date:2/24/2017)... SAN FRANCISCO, CA (PRWEB) , ... February 24, 2017 , ... ... awarding of a $224K grant from the National Institute of Mental Health (NIMH) for ... is based on Delpor’s PROZOR technology and is expected to deliver therapeutic ...
Breaking Biology Technology: