Navigation Links
New stage in fighting pancreatic cancer
Date:1/3/2012

A promising line of attack against pancreatitis and pancreatic cancer is to be explored further at Cardiff University, thanks to substantial new funding from the Medical Research Council (MRC).

Pancreatitis can develop when the enzymes needed for digestion turn on the pancreas itself. Chronic pancreatitis increases the risk of pancreatic cancer, which has the lowest five-year survival rate of all common cancers in the UK. High alcohol intake and gallstones are the most common causes of pancreatitis.

Last year, Professor Ole Petersen and colleagues at Cardiff University's School of Biosciences, revealed that a protein call calmodulin could protect the pancreas against the effects of alcohol. In cells without calmodulin, alcohol speeds up a chain reaction causing cells to self-destruct, leading to pancreatitis and potentially to pancreatic cancer. The team also discovered a calcium-like molecule which could boost the pancreas' natural protection against digestive enzymes. These breakthroughs have just been highlighted in the MRC's review of the most significant developments of 2011.

Now Professor Petersen's team has secured a 2M MRC Programme Grant to investigate the potential of the calcium-like molecule further. Over the next five years, they will test its ability to protect against enzymes in a number of circumstances known to trigger pancreatitis. The team will also investigate special cells in the pancreas called stellate cells. Little is known about stellate cells but they could be the link between chronic pancreatitis and the development of pancreatic cancer.

Professor Petersen has also has his MRC Professorship renewed the only post of its kind in Wales. He said: "These are extremely complex molecular processes but we believe they are crucial to our understanding of these painful and distressing diseases. We aim to identify ways of controlling these processes to help prevent and treat acute pancreatitis. We also hope to build on our existing knowledge to better understand stellate cells and block the onset of pancreatic cancer. We are extremely grateful to the MRC for their support and encouragement of this promising research avenue."


'/>"/>
Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related biology news :

1. Unknown species and larval stages of extremely long-legged beetles discovered by DNA test
2. Researchers characterize biomechanics of ovarian cells according to phenotype at stages of cancer
3. String blossom thinner proves effective across stages of bloom development
4. Cell Transplantation reports a success in treating end-stage liver disease
5. Active management of the third stage of labor reduces risk of bleeding
6. Pitt team finds protein that sets the stage for exchanges of DNA code in eggs and sperm
7. Report: Discovery networks hostage-taking a rare terror event
8. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
9. Aquatic life declines at early stages of urban development
10. Multistage nanovector system provides sustained delivery of siRNA cancer therapeutic in mice
11. Gene therapy sets stage for new treatments for inherited blindness, Penn veterinary researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... On Monday, the Department of Homeland Security ... solutions for the Biometric Exit Program. The Request for ... (CBP), explains that CBP intends to add biometrics to ... United States , in order to deter visa ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... -- Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring announced that after exhaustive ... the final acceptance by all three (3) Department ... (MAS) installed. Furthermore, Securus will have contracts for ... October, 2016. MAS distinguishes between legitimate wireless device ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 27, 2016 , ... Newly created 4Sight Medical Solutions ... the healthcare market. The company's primary focus is on new product introductions, to ... that are necessary to help companies efficiently bring their products to market. , ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: