Navigation Links
New source discovered for the generation of nerve cells in the brain
Date:12/1/2009

Particularly in Alzheimer's disease, nerve cell degeneration plays a crucial role. In the future, new therapeutic options may possibly be derived from steering the generation and/or migration mechanism. These findings have been published in the current issue of the renowned journal Nature Neuroscience. Until only a few years ago, neurogenesis the process of nerve cell development was considered to be impossible in the adult brain. The textbooks asserted that dead nerve cells could not be replaced. Then researchers discovered regions in the forebrain in humans in which new nerve cells can be generated throughout life. These so-called GABAergic cells use gamma-aminobutyric acid (GABA), a neurotransmitter of the central nervous system.

A research team of scientists led by Magdalena Gtz, director of the Institute of Stem Cell Research at Helmholtz Zentrum Mnchen and chair of the Department of Physiological Genomics of LMU, has now taken a closer look at this brain region in the mouse model. Their findings: Even in the forebrain, there are other nerve cells that are regularly generated the so-called glutamatergic nerve cells, which use glutamate as neurotransmitter. The stem cell researchers could prove this by means of a specific transcription factor: Tbr2 is only present in progenitor cells of glutamatergic nerve cells.

The newly generated nerve cells in the adult organism are located in the olfactory bulb, the region of the brain involved in the sense of smell. Nerve cells that use glutamate as a neurotransmitter are also responsible for memory storing and retrieving information. In Alzheimer dementia, alterations in the signal transduction pathways of these special cells play a significant role.

Magdalena Gtz explained the reason why this finding is so important: "Neural progenitor cells can generate these newly discovered glutamatergic nerve cells for the neighboring cerebral cortex for example after brain injury." The res
'/>"/>

Contact: Sven Winkler
presse@helmholtz-muenchen.de
49-893-187-3946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
2. UNH becomes first university in nation to use landfill gas as primary energy source
3. New partnership offers outsourced R&D in membrane biology
4. HortTalks, a valuable scientific resource
5. Reversing cognitive deficits: Injectable antibody may attack source of problem
6. The race for biofuels driving alternative sources of biomass
7. Space technology put into service for global water resources observations
8. Local sources major cause of US near-ground aerosol pollution
9. The power of multiples: Connecting wind farms can make a more reliable - and cheaper - power source
10. GBIF making the search for biodiversity research resources easier
11. Food source threatened by carbon dioxide
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)...   HOYOS Labs , a leading global authentication ... the Company will demonstrate multiple biometrics-based technologies under its ... Connect:ID on March 23 through 25, 2015, in ... the IEEE Biometric Open Protocol Standard; free biometrics-based consumer ... control system. BOPS was invented by HOYOS Labs and ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report to ... for Iris Biometrics in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Latin America . ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... with environmental threats like bad weather, predators or oil ... researchers have analyzed blood samples to detect corticosterone levels ... have shown that corticosterone spikes can also be detected ... in the May 11 online edition of " Journal ...
... From hot pink to traditional French and Lady Gaga,s sophisticated ... But they are not just pretty when nails appeared ... million years ago, they led to the development of critical ... the ability to grasp, whether it,s a nail polish brush ...
... has seeded the Salk Institute as the number one research ... plant biologists, Joe Ecker, Ph.D., Joanne Chory, Ph.D. Jeff Long, ... the number of highly cited papers with the most impact, ... world with the greatest number of highly cited papers (top ...
Cached Biology News:A tool to measure stress hormone in birds -- feathers 2Researchers discover oldest evidence of nails in modern primates 2Researchers discover oldest evidence of nails in modern primates 3Salk Institute named global leader in plant biology research 2
(Date:3/25/2015)... 2015 An increase of awareness related ... forms of food nutrients, regulatory changes and concerns related ... in demand for natural astaxanthin over the past few ... up their capacities to satisfy the rising demand. ... source astaxanthin (used in nutraceuticals, aqua feed, food and ...
(Date:3/25/2015)... the HAGUE, Netherlands , March 25, ... LES Stimulation therapy for chronic gastro-esophageal reflux disease (GERD) ... [ Surgery . 2015; 157(3):556-567 ], establishing ... therapy. The study included 25 patients ... years and taking prescribed daily proton pump inhibitor (PPI) ...
(Date:3/25/2015)... Proove Biosciences , a commercial and research ... success of their commercially supported symposium, Personalized Medicine ... Management of Pain, at the 31st Annual American Academy ... Thursday, March 19th, 2015. , The symposium’s ... Webster , M.D., former Florida Society of Interventional Pain ...
(Date:3/25/2015)... DNA Spectrum , a leading consumer ... product earlier this year. This consumer offering is designed ... currently stands. It does so through analysis of customers’ ... affect physical fitness. Once this analysis is completed, myDNA ... effects with the client's body profile and the latest ...
Breaking Biology Technology:Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 2DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 3DNA Spectrum Educates the Bay Area Fitness Community about myDNA Fitness at SCW California MANIA 4
... SAN DIEGO, Nov. 8, 2010 Vet-Stem, Inc. announced ... LTD (AVSC) has been completed which secures Vet-Stem,s third ... veterinarians for treating horses, dog and cats.  AVSC is ... services in Australia, New Zealand and Singapore.   ...
... Savara Inc., an inhalation product development company, today ... Board of Directors. In 1983 Mr. Hawkins ... guided the growth of that organization to over 700 ... largest clinical contract research organizations in the world. Since ...
... ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var r ...
Cached Biology Technology:Vet-Stem Signs License Agreement With Affiliate in Australia for Veterinary Stem Cells 2Savara Announces Appointment of Pharmaceutical Veteran to Board of Directors 2OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 2OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 3OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 4OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 5OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 6OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 7OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 8OncoGenex Pharmaceuticals Names Michelle Burris Executive Vice President, Operations and Chief Financial Officer 9
Recognizes the ~115 kDa NMDA receptor NR1 subunit in rat cortex tissue extracts....
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
... joining of two strands of DNA between ... adjacent nucleotides in either a cohesive-ended or ... been shown to catalyze the joining of ... strand in a duplex molecule but will ...
... Darkroom is designed for imaging of chemiluminescent, ... systems offer direct control for users who ... by hand , A range of high ... for all fluorescent and chemiluminescent applications ...
Biology Products: