Navigation Links
New 'smart' nanotherapeutics can deliver drugs directly to the pancreas
Date:1/12/2012

BOSTON, January 12, 2012: A research collaboration between the Wyss Institute for Biologically Inspired Engineering at Harvard University and Children's Hospital Boston has developed "smart" injectable nanotherapeutics that can be programmed to selectively deliver drugs to the cells of the pancreas. Although this nanotechnology will need significant additional testing and development before being ready for clinical use, it could potentially improve treatment for Type I diabetes by increasing therapeutic efficacy and reducing side effects.

The approach was found to increase drug efficacy by 200-fold in in vitro studies based on the ability of these nanomaterials to both protect the drug from degradation and concentrate it at key target sites, such as regions of the pancreas that contain the insulin-producing cells. The dramatic increase in efficacy also means that much smaller amounts of drugs would be needed for treatment, opening the possibility of significantly reduced toxic side effects, as well as lower treatment costs.

The research was led by Wyss Institute Founding Director Donald Ingber M.D., Ph.D. and Kaustabh Ghosh, Ph.D., a former postdoctoral fellow at Children's Hospital Boston. Their findings appear in the current issue of Nano Letters. Ingber is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Children's Hospital Boston, and Professor of Bioengineering at Harvard's School of Engineering and Applied Sciences. Ghosh is now an Assistant Professor of Bioengineering at the University of California, Riverside. Wyss Institute Postdoctoral Fellows, Umai Kanapathipillai and Netanel Korin, also contributed to the work, as did Jason McCarthy, Assistant Professor in Radiology at Harvard Medical School and an Assistant in Chemistry at Massachusetts General Hospital.

Type I diabetes, which often strikes children and young adults, is a debilitating disease in which the body's immune system pro
'/>"/>

Contact: Twig Mowatt
twig.mowatt@wyss.harvard.edu
617-432-1547
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert

Page: 1 2

Related biology news :

1. WPI receives $1.2 million to develop smart phone app for advanced diabetes and wound care
2. SmartActions Artificial Intelligence IVR Solution Receives PCI Certification
3. Climate-smart agriculture should be livelihood-smart too
4. Smart swarms of bacteria inspire robotics researchers
5. NIH awards group $4.5 million for smart artificial pancreas technology
6. Smarter toxins help crops fight resistant pests
7. Caltech engineers build smart petri dish
8. Card Logistics to Auction Smart Card Gaming Technology at Upcoming ICAP Patent Brokerage Fall 2011 Live IP Auction in San Francisco
9. Sea smarts: Scientists reconstruct evolutionary history of mollusks
10. Outsmarting algae -- RIT scientist finds the turn-off switch
11. LCC science projects receive $1.2 million through WaterSMART program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... traditional cigarettes, but still release toxins into the ... , Scientists studying secondhand smoke from e-cigarettes discovered ... particles, with close-to-zero exposure to organic carcinogens. However, ... second-hand e-cigarette smoke were found to be significantly ... of polycyclic aromatic hydrocarbons cancer-causing organic compounds ...
(Date:8/28/2014)... at the University of Minnesota have developed an animal ... used for muscle regeneration research as well as studies ... The research is published in the current edition of ... no treatment for FSHD, which is thought by many ... FSHD is an unusual genetic disorder because, unlike most ...
(Date:8/28/2014)... -- Scientists have identified the developmental on-off switch for ... produce more than two-thirds of the world,s naturally derived ... to see whether it is possible to manipulate this ... , The study, appearing August 28 in Cell ... molecule called cyclic-di-GMP and a larger protein called BldD ...
Breaking Biology News(10 mins):Second-hand e-cig smoke compared to regular cigarette smoke 2UMN researchers find animal model for understudied type of muscular dystrophy 2Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3
... of government from around the world today agreed at a ... fill a serious void in leadership related to global water ... nonexistent," the retired leaders say the panel will work to ... a looming "water crisis." The 20 members of the ...
... In the treeless, flat Prairie, you,d think a city would ... up and roost in trees and buildings. But researchers at ... urban landscape is far from ideal for these animals. ... lecturer and recent PhD graduate in biological sciences at the ...
... Institute scientists has found a key biological mechanism underpinning ... door to the development of drugs to manage excessive ... much of our lab,s research, was to examine the ... drinking driven by the aversive aspects of alcohol withdrawal," ...
Cached Biology News:Void in leadership on world water crisis cited by 20 former heads of government 2Big city holds empty promise for bats 2Scripps Research scientists find key mechanism in transition to alcohol dependence 2Scripps Research scientists find key mechanism in transition to alcohol dependence 3
(Date:8/28/2014)... The ability for organizations to attract top ... individuals to perform at the highest of levels, are ... to compete in this post–recession era. The pharmaceutical ... the sector increasingly focuses on the importance of employee-fit ... real results on the organization's development and the innovation ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Supplementing ... offering a promotion for Eppendorf Safe Lock ... to purchase the highest quality tubes at an ... ideal for customers doing chemical, medical, pharmaceutical, and ... who are not regularly able to afford Eppendorf ...
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... right now. It's the new magic elixir that will solve ... swells. Then we'll go skipping off hand-in-hand through a sun-drenched ... was touting partnership just last week in this column, but ... the right relationship answer only if all involved are willing ...
... BLOOMFIELD HILLS, Mich. Logicalis , an international ... and storage solution providers, announced Monday it has acquired ... solution provider and one of IBM's top 10 Business ... also executed a letter of intent to purchase a ...
... advantage obsolete? Today, competitors can copy the newest ... or low-cost back-office process seemingly overnight. Indeed, it ... for long. This realization has led many corporate ... strategy to pursue is to create organizations that ...
Cached Biology Technology:Blooming partnerships 2Blooming partnerships 3Blooming partnerships 4Logicalis purchases Solution Technology for $90M 2Going beyond me, too customer experiences 2Going beyond me, too customer experiences 3Going beyond me, too customer experiences 4
... Jouan MSC series of Class II ... conditions and certification to the world's ... ensures that the cabinets cannot be ... Natural lighting, low noise and arm ...
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... designed for paramagnetic bead precipitation from standard ... plates with no additional accessories. The stand ... standard SBS 96-well microplate footprint. The use ... easy and fast (as little as 30 ...
... unit ideal for use in laboratories with low ... set at 12 rpm , Temperature control ... capacity of four 35 x 150mm bottles, eight ... , Consistent, repeatable results achieved with microprocessor ...
Biology Products: