Navigation Links
New simple setup for X-ray phase contrast
Date:7/11/2014

This news release is available in German.

X-ray phase-contrast imaging is a method that uses the refraction of X-rays through a specimen instead of attenuation resulting from absorption. The images produced with this method are often of much higher quality than those based on absorption. The scientists in the team of Prof. Franz Pfeiffer are particularly interested in developing new approaches for biomedical X-ray imaging and therapy including X-ray phase-contrast imaging. One main goal is to make this method available for clinical applications such as diagnosis of cancer or osteoporosis in the future.

In their new study, the scientists have now developed an extremely simple setup to produce X-ray phase-contrast images. The solution to many of their difficulties may seem counter-intuitive: Scramble the X-rays to give them a random structure. These speckles, as they are called in the field, encode a wealth of information on the sample as they travel through it. The scrambled X-rays are collected with a high-resolution X-ray camera, and the information is then extracted in a post-measurement analysis step.

High accuracy and new X-ray source

Using their new technique, the researchers have demonstrated the efficiency and versatility of their approach. "From a single measurement, we obtain an attenuation image, the phase image, but also a dark-field image," explains Dr. Irene Zanette, lead author of the publication. "The phase image can be used to measure accurately the specimen's projected thickness. The dark-field image can be just as important because it maps structures in the specimen too small to be resolved, such as cracks or fibers in materials," she adds.

The source's high brightness is also key to these results. "In the source we used a liquid metal jet as the X-ray-producing target instead of the solid targets normally used in laboratory X-ray sources," says Tunhe Zhou from KTH Stockholm, project partner of the TUM. "This makes it possible to gain the high intensity needed for phase-contrast imaging without damaging the X-ray-producing target." To obtain all images at once, an algorithm scans the speckles and analyzes the minute changes in their shape and position caused by the specimen.

But not all components of the new instrument are products of the latest cutting-edge technology. To scramble the X-rays, "we have found that a simple piece of sandpaper did the job perfectly well," adds Dr. Zanette.

The researchers are already working toward the next steps. "As a single-shot technique, speckle imaging is a perfect candidate for an efficient extension to phase-contrast tomography, which would give a three-dimensional insight into the microstructure of the investigated object," Zanette explains.


'/>"/>

Contact: Vera Siegler
vera.siegler@tum.de
49-892-892-2731
Technische Universitaet Muenchen
Source:Eurekalert

Related biology news :

1. Consumers need simple, concise messages about benefits of phytonutrients
2. ORNL microscopy yields first proof of ferroelectricity in simplest amino acid
3. Simple mathematcal pattern describes shape of neuron jungle
4. Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus
5. Researchers identify a simple way to precipitate phosphorus from the wastewater of a pulp mill
6. Unraveling the threads: Simplest cotton genome offers clues for fiber improvements
7. Early human burials varied widely but most were simple
8. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
9. Simple plants arent always easy: Revision of the liverwort Radula buccinifera complex
10. New, simple technique may drive down biofuel production costs
11. Simple sequence repeats for population-level studies of pines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)... 12, 2017  New research undertaken by Fit Small ... future.  1,000 participants were simply asked which office technology had ... may consider standard issue.  Insights on what will ... gathered from futurists and industry leaders including Penelope Trunk ... .  Some of these findings ...
(Date:1/11/2017)... Johnson, co-founder of Visikol Inc. a company originally funded with an ... the elite "Forbes 30 Under 30" list in the Science category. ... fields nationwide to be recognized as a leader in business and ... ... PhD candidate at Rutgers University. Visikol , ...
(Date:1/6/2017)... , Jan. 5, 2017  Delta ID Inc., a ... scanning technology for automotive at CES® 2017. Delta ID ... ) to demonstrate the use of iris scanning as ... authenticate the driver in a car, and as a ... driving experience. Delta ID and Gentex will ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... 2017 The Global Implantable Biomaterials Market ... around 7.5% over the next decade to reach ... prominent trends that the market is witnessing include ... graft transplant surgeries and medical implants and technological ... categorized into immunomodulatory biomaterials, natural, polymers, hydrogels and ...
(Date:1/17/2017)... , Jan. 17, 2017  Zimmer Biomet Holdings, ... quarter and full-year 2016 sales and earnings conference call ... January 31, 2017, at 8 a.m. Eastern Time.  A ... be made available at 7:30 a.m. Eastern Time the ... audio webcast can be accessed via Zimmer Biomet,s Investor ...
(Date:1/17/2017)... Jan. 17, 2017 Research and Markets ... "Molecular Diagnostics - Technologies, Markets and Companies" to their ... ... increased remarkably during the past few years. More than 1,000 ... diagnostics and 342 of these are profiled in the report ...
(Date:1/17/2017)... Cleveleys, UK (PRWEB) , ... ... ... results presented by surgeons at the 2016 annual meeting of the North ... beneficial clinical outcomes, for patients in the majority of cases, when PEEK-OPTIMA™ ...
Breaking Biology Technology: