Navigation Links
New simple setup for X-ray phase contrast
Date:7/11/2014

This news release is available in German.

X-ray phase-contrast imaging is a method that uses the refraction of X-rays through a specimen instead of attenuation resulting from absorption. The images produced with this method are often of much higher quality than those based on absorption. The scientists in the team of Prof. Franz Pfeiffer are particularly interested in developing new approaches for biomedical X-ray imaging and therapy including X-ray phase-contrast imaging. One main goal is to make this method available for clinical applications such as diagnosis of cancer or osteoporosis in the future.

In their new study, the scientists have now developed an extremely simple setup to produce X-ray phase-contrast images. The solution to many of their difficulties may seem counter-intuitive: Scramble the X-rays to give them a random structure. These speckles, as they are called in the field, encode a wealth of information on the sample as they travel through it. The scrambled X-rays are collected with a high-resolution X-ray camera, and the information is then extracted in a post-measurement analysis step.

High accuracy and new X-ray source

Using their new technique, the researchers have demonstrated the efficiency and versatility of their approach. "From a single measurement, we obtain an attenuation image, the phase image, but also a dark-field image," explains Dr. Irene Zanette, lead author of the publication. "The phase image can be used to measure accurately the specimen's projected thickness. The dark-field image can be just as important because it maps structures in the specimen too small to be resolved, such as cracks or fibers in materials," she adds.

The source's high brightness is also key to these results. "In the source we used a liquid metal jet as the X-ray-producing target instead of the solid targets normally used in laboratory X-ray sources," says Tunhe Zhou from KTH Stockholm, project partner of the TUM. "This makes it possible to gain the high intensity needed for phase-contrast imaging without damaging the X-ray-producing target." To obtain all images at once, an algorithm scans the speckles and analyzes the minute changes in their shape and position caused by the specimen.

But not all components of the new instrument are products of the latest cutting-edge technology. To scramble the X-rays, "we have found that a simple piece of sandpaper did the job perfectly well," adds Dr. Zanette.

The researchers are already working toward the next steps. "As a single-shot technique, speckle imaging is a perfect candidate for an efficient extension to phase-contrast tomography, which would give a three-dimensional insight into the microstructure of the investigated object," Zanette explains.


'/>"/>

Contact: Vera Siegler
vera.siegler@tum.de
49-892-892-2731
Technische Universitaet Muenchen
Source:Eurekalert

Related biology news :

1. Consumers need simple, concise messages about benefits of phytonutrients
2. ORNL microscopy yields first proof of ferroelectricity in simplest amino acid
3. Simple mathematcal pattern describes shape of neuron jungle
4. Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus
5. Researchers identify a simple way to precipitate phosphorus from the wastewater of a pulp mill
6. Unraveling the threads: Simplest cotton genome offers clues for fiber improvements
7. Early human burials varied widely but most were simple
8. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
9. Simple plants arent always easy: Revision of the liverwort Radula buccinifera complex
10. New, simple technique may drive down biofuel production costs
11. Simple sequence repeats for population-level studies of pines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... ... ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension of ... higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... of the cuvette holder. , FireflySci has developed several Agilent flow cell product ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: