Navigation Links
New screening technique yields elusive compounds to block immune-regulating enzyme
Date:5/11/2012

LA JOLLA, CA May 10, 2012 Scientists at The Scripps Research Institute have found the first chemical compounds that act to block an enzyme that has been linked to inflammatory conditions such as asthma and arthritis, as well as some inflammation-promoted cancers.

The new study, published recently by the journal ACS Chemical Biology, describes new compounds that inhibit an important enzyme called PRMT1 (protein arginine methyltransferase 1). The new inhibitors will be useful to scientists who study PRMT1-related biological pathways in cells and who are developing drug treatments for PRMT1-related inflammatory conditions and cancers.

Standard screening techniques had been unable to distinguish between compounds that inhibit PRMT1 and those that inhibit other common PRMT family enzymes. In the new study, scientists from several Scripps Research laboratories collaborated to devise the first PRMT1-specific screening technique. "We were able to target a screening probe to a specific amino acid found on PRMT1, but not on most other PRMT enzymes," said the study's principal investigator Scripps Research Assistant Professor Kerri A. Mowen.

Mowen has been studying PRMT1 since her graduate school days, and, like others in the field, has been acutely aware of the need for selective PRMT1 inhibitors. The enzyme modifies the functionality of proteins by attaching a methyl group to their arginine amino acids; as such, it is involved in some of the most basic processes in cells. For example, Mowen and her colleagues showed in 2004 that PRMT1 helps drive the production of the key immune-stimulating proteins interferon-gamma and interleukin-4.

But although PRMT1 was known to be responsible for nearly all the arginine methylation that goes in mammalian cells, no one had been able to develop selective PRMT1 inhibitors, since the 10 other PRMT enzymes are nearly identical, structurally and biochemically. Even the removal of PRMT1's
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Nanoscopic screening process to speed drug discovery
2. Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
3. Genetic risk factors may tailor prostate cancer screening approaches
4. Rural areas able to increase screening capacity for colorectal cancer
5. States expand newborn screening for life-threatening disorders
6. New technique for cancer screening
7. New high-throughput screening technique makes probing puzzling proteins possible
8. American College of Medical Genetics affirms importance of newborn screening dried blood spots
9. Colon cancer screening technique shows continued promise in new study
10. ESHRE launches international study of polar body screening
11. Pitt team finds molecule that regulates heart size by using zebrafish screening model
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New screening technique yields elusive compounds to block immune-regulating enzyme
(Date:7/8/2015)... -- The consumer products industry for innovative tech ... such as wearables, smart wallets & other smart technology are ... continues to rapidly grow.  Biometrics & Wearable Device Companies in ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: AAPL ... GPRO ) and Baidu Inc. (NASDAQ: BIDU ) ...
(Date:7/2/2015)... , June 25, 2015 ... announced the addition of the "Natural Language ... Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... their offering. The key vendors occupying ... HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS ...
(Date:6/30/2015)... Genisphere announced Tom Bliss ... further develop Genisphere,s therapeutics capabilities and portfolio. Mr. Bliss ... much of the last 25 years in leadership positions ... Johnson & Johnson. Tom started his career in Investment ... Finance. He graduated from Dartmouth College with a BA ...
Breaking Biology News(10 mins):Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 2Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 3Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 4Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 5Consumers Flock to This Summer's Must Have Tech Gadgets as Latest Digital Wallets, Smart Technology & Wearable Products Continue to Grow in Popularity & Functionality 6Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... 2013  Pfenex Inc. today announced that the Department of ... Research and Development Authority (BARDA), has modified its prime ... existing Pfenex contractual relationship begun in July, 2010. This ... support the development of a next generation rPA-based anthrax ...
... Resveratrol, a naturally occurring polyphenol compound produced by the ... red wine, has been touted as a beneficial supplement ... been supported by some experimental studies, whereas others suggest ... multiple sclerosis (MS) models published in The American ...
... Sept. 30, 2013 /PRNewswire-iReach/ -- Clinilabs, a contract research ... services to industry, announced today that they have begun ... medication for Type 2 Diabetes Mellitus.  The study is ... multiple daily doses of the investigational medication over periods ...
Cached Biology News:Biomedical Advanced Research and Development Authority (BARDA) Exercises Option with Pfenex Inc. To Extend Contract and Increase Funding for the Development of a Recombinant Protective Antigen (rPA) Based Anthrax Vaccine 2Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice 2Resveratrol, found in red wine, worsens MS-like symptoms and neuropathology in mice 3Leading Pharma Company Selects Clinilabs to Conduct a Phase 1 Study of an Investigational Type 2 Diabetes Medication 2
(Date:7/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/z54c4k/biomedical ) ... Refrigerators and Freezers Market - Global Industry Analysis, ... 2022" report to their offering. ... has been segmented based on applications: hospitals, research ... The others segment includes applications of biomedical refrigerators ...
(Date:7/28/2015)... July 28, 2015 Deerfield Management Company, L.P. ... Fund, L.P., which will invest in groundbreaking advancements in ... diseases, cancer, and orphan diseases. The venture capital fund ... therapeutics are developed and improve the way healthcare is ... the largest healthcare-focused venture funds in the sector, will ...
(Date:7/28/2015)... DIEGO , July 28, 2015  Kerastem Technologies ... approval from the U.S. FDA Center For Biologics Evaluation ... Therapies to conduct a clinical trial investigating the safety ... of female and early male pattern baldness (androgenic alopecia). ... STYLE trial, follows initial clinical work in ...
(Date:7/28/2015)... BEACH, Calif. , July 28, 2015 /PRNewswire-USNewswire/ ... announced that it has hit a milestone of ... Signafuse was FDA 510(k) cleared in early 2014 ... use in posterolateral spine fusion procedures.  This is ... products, as less than 6% of new synthetic ...
Breaking Biology Technology:Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3Deerfield Launches $550 Million Healthcare Venture-Capital Fund 2Deerfield Launches $550 Million Healthcare Venture-Capital Fund 3Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2Revolutionary Bone Graft Exceeds Expectations 2
... chain technology solutions provider, today announced the opening of ... staff of twenty, the office will grow to sixty ... responsible for sales, customer support and product development for ... industry to establish Asia-Pacific headquarters in China. , ...
... Street Journal featured the news of pharmaceutical giant ... for $1.3 billion. , ,Esperion, which is based ... be useful for the treatment of the heart disease ... with drugs like Lipitor for high cholesterol ($8 billion ...
... , a start-up formed by two UW-Madison students, was acquired ... cash. The Sioux Falls, S.D.-based Raven is a manufacturing company, ... ammonia for farmers, is expected to complement Ravens existing line ... for us at Fluent as it marks the culmination of ...
Cached Biology Technology:Holiday Gift From Big Pharma 2
... RNase H degrades, as an endoribonuclease, ... DNA hybrids of natural origin, e.g. ... synthetic complexes, e.g. poly(A) x poly(dT). ... and 3-OH termini. Nearly no activity ...
Unit Definition: 1 U corresponds to the amount of enzyme which produces 1 mol protons per minute at pH 5.5 and 30C (peptin from citrus peel, Fluka-No. 76280, as substrate)...
Recorder, 6", 7 Day, 1 Pen, 0 to 100°C, 220V, 50/60 Hz, for 4520, Customer Installed...
... detection systems provide linking and labelling ... species specific primary antibodies for visualising ... is accomplished using an ultra-sensitive indirect ... labelling technology. Secondary antibodies are polymerised ...
Biology Products: