Navigation Links
New screen offers hope for copper deficiency sufferers
Date:8/17/2010

Copper deficiency diseases can be devastating. Symptoms can range from crippling neurological degeneration in Menkes disease a classic copper deficiency disease to brittle bones, anaemia and defective skin pigmentation in gastric bypass patients. Unfortunately, very little is known about how the body uses this essential nutrient. Knowing that melanocytes (the cells that give rise to hair, skin and eye pigmentation) are dramatically affected by the effects of copper deficiency, Elizabeth Patton from the University of Edinburgh, UK, and other colleagues from UK- and US-based labs decided to find out how melanocytes metabolise copper. Patton and her colleagues publish their results in Disease Models and Mechanisms on August 17, 2010 at http://dmm.biologists.org/.

Patton explains that zebrafish are a valuable research tool because they are an intermediate organism between mammals and the simpler creatures that scientists routinely use to study genetic disorders. She usually uses zebrafish to understand how melanocytes develop and how these cells can give rise to malignant melanoma, a lethal form of cancer. Testing compounds that she hoped might prevent malignant melanoma symptoms in zebrafish, she was puzzled to find a compound that caused the fish to lose their characteristic zebra-stripe patterns. After spending months trying to determine why the fish lost their stripes, she crossed paths with Jonathan Gitlin, a copper deficiency specialist from Vanderbilt University, USA, and realised that the stripeless fish might have copper deficiency.

To understand the molecular pathways involved in copper deficiency, Patton and Gitlin teamed up with Mike Tyers from the University of Edinburgh and developed an elegant method to probe copper metabolism in zebrafish. First, the team identified compounds that caused zebrafish to lose their stripes indicating copper deficiency. Next, they identified the genes
'/>"/>

Contact: Sarah Allan
sarah.allan@biologists.com
44-752-876-8387
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. EPA and other federal agencies collaborate to improve chemical screening
2. Evidence that nanoparticles in sunscreens could be toxic if accidentally eaten
3. Compound screening for drug development made simpler
4. Is prenatal screening for rare diseases like spinal muscular atrophy too costly?
5. Startup joins UCLA tech incubator to develop technologies for drug discovery, screening
6. Scripps Research scientists create new way to screen libraries of 10 million or more compounds
7. New bioanalytical methods have potential for investigative and screening applications
8. Rodent smoke screen
9. Many pregnant women avoid HIV screening in Africa
10. Statement of ESHRE on the European Commission proposal of viral screening
11. New Web site promotes interoperable newborn screening data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... 2015   Guidepoint , a leading global research ... Pain Management TRACKER, part of the Guidepoint TRACKER ... the medical device and therapeutics markets. The Post-Surgical Pain ... volumes, market share, and adoption rates across three major ... surgery. The Post-Surgical Pain Management TRACKER will ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... the "Global Iris Recognition Market 2015-2019" report ... Global Iris Recognition market to grow at a CAGR ... This report covers the present scenario and the growth ... period 2015-2019. To calculate the market size, the report ...
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2
... advocates will gather at Arizona State University for the ... 16-18, 2011. The conference will be a premier ... new approach to battling cancer: the development of ... disease. Despite 40 years since the "War on ...
... (IOF) and the World Health Organization Collaborating Centre for Metabolic ... launch of a FRAX calculator for Singapore. The ... been developed by the WHO to help evaluate patients at ... clinical risk factors, with or without the use of bone ...
... a major cause of plant diseases and are responsible ... other cereals all over the world. Together with scientists ... the Max Planck Institute for Terrestrial Microbiology in Marburg, ... University of Gttingen, analysed the genetic make-up of Sporisorium ...
Cached Biology News:Experts converge at Arizona State University for first preventive cancer vaccine conference 2WHO Fracture Risk Assessment Tool (FRAX) newly released for Singapore 2Evolutionary arms race between smut fungi and maize plants 2Evolutionary arms race between smut fungi and maize plants 3
(Date:4/17/2015)... 2015 LC Sciences LLC, a ... today that it is seeking beta testers for ... PCR based targeted sequencing technology. The system offers ... enables accurate detection of rare variants. It utilizes ... The company will collaborate with beta testers to ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 Cytokinetics, Incorporated ... report first quarter results on Thursday, April 30, 2015 ... senior management will host a conference call at 4:30 ... and the company’s outlook for the future. , The ... accessed from the homepage and in the Investor Relations ...
(Date:4/16/2015)... Ohio (PRWEB) April 16, 2015 ... Index, overexertion involving an outside source was ranked ... This includes injuries related to lifting, pushing, pulling, ... billion in direct costs. The David Round Company ... is committed to working hard to develop and ...
(Date:4/16/2015)... , April 16, 2015  RegeneRx Biopharmaceuticals, ... announced its U.S. joint venture with G-treeBNT (ReGenTree ... phase 3 clinical trial for the orphan disorder, ... trial for dry eye syndrome (DES) in the ... eye drops, RGN-259/GBT201, this year.  Each of these ...
Breaking Biology Technology:LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5
... and VANCOUVER, Aug. 3 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals (NASDAQ: ... second quarter financial results on Thursday, August 6, 2009. OncoGenex ... p.m. EDT that afternoon to discuss quarterly results. , The ... the OncoGenex Web site at www.oncogenex.com . Alternatively, you ...
... ... Training Programme (JWTP) in India from October 6-10, 2009" is all set ... Jatropha and other Oil Crop Projects, Programmes and Priorities to Feed Biodiesel ... last year,s event, and a number of alternative feedstocks emerged over the ...
... ... MicroFuelerTM Installation , ... CA (PRWEB) August 1, 2009 -- The future of filling up your tank at home ... into a high performance ethanol fuel for cars was installed Thursday night at a home ...
Cached Biology Technology:Global Jatropha Hi-Tech Agricultural Training Programme (JWTP) 2Global Jatropha Hi-Tech Agricultural Training Programme (JWTP) 3Global Jatropha Hi-Tech Agricultural Training Programme (JWTP) 4America's Organic Home-Fueling Movement Begins in Los Angeles 2America's Organic Home-Fueling Movement Begins in Los Angeles 3
Viral CCI Biotinylated Affinity Purified PAb...
Human RXR beta/NR2B2 MAb (Clone H7341) Keywords: RXRbeta, RXRbeta, Retinoid X Receptor beta...
Human SOST Affinity Purified Polyclonal Ab...
BOND ELUT MATRIX-C18, 25 mg ...
Biology Products: