Navigation Links
New screen offers hope for copper deficiency sufferers
Date:8/17/2010

Copper deficiency diseases can be devastating. Symptoms can range from crippling neurological degeneration in Menkes disease a classic copper deficiency disease to brittle bones, anaemia and defective skin pigmentation in gastric bypass patients. Unfortunately, very little is known about how the body uses this essential nutrient. Knowing that melanocytes (the cells that give rise to hair, skin and eye pigmentation) are dramatically affected by the effects of copper deficiency, Elizabeth Patton from the University of Edinburgh, UK, and other colleagues from UK- and US-based labs decided to find out how melanocytes metabolise copper. Patton and her colleagues publish their results in Disease Models and Mechanisms on August 17, 2010 at http://dmm.biologists.org/.

Patton explains that zebrafish are a valuable research tool because they are an intermediate organism between mammals and the simpler creatures that scientists routinely use to study genetic disorders. She usually uses zebrafish to understand how melanocytes develop and how these cells can give rise to malignant melanoma, a lethal form of cancer. Testing compounds that she hoped might prevent malignant melanoma symptoms in zebrafish, she was puzzled to find a compound that caused the fish to lose their characteristic zebra-stripe patterns. After spending months trying to determine why the fish lost their stripes, she crossed paths with Jonathan Gitlin, a copper deficiency specialist from Vanderbilt University, USA, and realised that the stripeless fish might have copper deficiency.

To understand the molecular pathways involved in copper deficiency, Patton and Gitlin teamed up with Mike Tyers from the University of Edinburgh and developed an elegant method to probe copper metabolism in zebrafish. First, the team identified compounds that caused zebrafish to lose their stripes indicating copper deficiency. Next, they identified the genes
'/>"/>

Contact: Sarah Allan
sarah.allan@biologists.com
44-752-876-8387
The Company of Biologists
Source:Eurekalert

Page: 1 2

Related biology news :

1. EPA and other federal agencies collaborate to improve chemical screening
2. Evidence that nanoparticles in sunscreens could be toxic if accidentally eaten
3. Compound screening for drug development made simpler
4. Is prenatal screening for rare diseases like spinal muscular atrophy too costly?
5. Startup joins UCLA tech incubator to develop technologies for drug discovery, screening
6. Scripps Research scientists create new way to screen libraries of 10 million or more compounds
7. New bioanalytical methods have potential for investigative and screening applications
8. Rodent smoke screen
9. Many pregnant women avoid HIV screening in Africa
10. Statement of ESHRE on the European Commission proposal of viral screening
11. New Web site promotes interoperable newborn screening data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... ANTONIO, September 18, 2014 New research into the ... causes a severe hemorrhagic disease in humans similar to ... essential for CCHFV infection. This discovery has the potential ... the pathogen. , The research, reported in ... Pathogens and conducted by scientists at the Texas ...
(Date:9/18/2014)... researchers from McGill University and the Quebec government ... ,microbeads, Canadian Journal of Fisheries and Aquatic ... cosmetics, household cleansers, or industrial cleansers, to which ... their small size and buoyancy, they may readily ... a global contaminant in the world,s oceans, but ...
(Date:9/18/2014)... how many times it,s demonstrated, it,s still hard ... , But by using a signaling system called ... behavior to suit their population. In short, some ... and act accordingly. , Once the population of ... from innocuous to pathogenic, or from unhelpful to ...
Breaking Biology News(10 mins):Research milestone in CCHF virus could help identify new treatments 2Microplastic pollution discovered in St. Lawrence River sediments 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3
... nannies help out, especially if they,ve been sneaking ... displays cooperative breeding behavior, where non-parents contribute to ... now, it was assumed that male subordinates never gained ... 12, in the online journal PLoS ONE , ...
... , This release is available in French ... Concordia University professors have received new funding to advance research ... of a peer committee, Canada Research Chairs were awarded to ... The announcement was made at Concordia in the ...
... of investigators from the University of Utah has received a ... to fund novel research that may help to uncover a ... multiple sclerosis. These studies will use an advanced technology called ... of primary progressive multiple sclerosis. Multiple sclerosis (MS), which ...
Cached Biology News:Recognition for 7 Concordia professors 2NIH grant will allow researchers to look for viral cause of most severe form of multiple sclerosis 2
(Date:9/18/2014)... 2014 OMICS Group International invites ... participate in the ‘Open Access Week’ by actively ... OMICS Group Pharma Journals from 20-26th October, ... fastest emerging Sciences, accelerating with a tremendous speed ... the globe. The industry is gearing with innovation ...
(Date:9/18/2014)... lab can be pretty expensive. Now a team led ... an open-source library of designs that will let scientists ... equipment: the syringe pump. , Syringe pumps are used ... delivery or mixing chemicals in a reaction. They can ... Joshua Pearce and his team of Michigan Tech students ...
(Date:9/18/2014)... we touch in the course of a day ... medicines, rely on the chemical industry to turn ... farm products into valuable chemicals that are the ... Dr Sarina Sarina, who achieved outstanding progress in ... ambient temperature using light instead of fossil fuels, ...
(Date:9/18/2014)... Pipette.com announces brand new ... and AccuPet brand of pipettes. Micropipettes are ideal ... less and are a great tool for molecular ... The micropipette promotions were designed to offer a ... to help customers find the right solution. Brands ...
Breaking Biology Technology:Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Doing science just got cheaper -- and faster 2Using solar energy to turn raw materials into ingredients for every day life 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 2Major Pipette Distributor Pipette.com Announces Promotions on Sartorius/Biohit, Socorex, Capp, and AccuPet Micropipettes 3
... Skills Related to Nutrition Care in Mosby,s ... Organization Elsevier/MC Strategies , a pioneer ... organizations announced today its collaboration with the American ... review and amend the nutrition-related skills in Mosby,s Nursing ...
... design, University at Buffalo chemists have synthesized tiny, molecular ... nanomaterials. , Sculpted from a special kind of molecule ... organic tubes whose interior walls carry a negative charge. ... positively charged particles. , In addition, because UB scientists ...
... Levi & Korsinsky is investigating potential claims on behalf ... California, Inc. ("PacBio" or the "Company") (NASDAQ: ... For more information, click here: http://zlk.9nl.com/pacific-biosciences-california-pacb/ ... that the Company failed to disclose the following: (a) ...
Cached Biology Technology:Elsevier Collaborates with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 2Elsevier Collaborates with the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) 3Chemists become molecular sculptors, synthesizing tiny, molecular traps 2Chemists become molecular sculptors, synthesizing tiny, molecular traps 3The Law Firm of Levi & Korsinsky, LLP Launches an Investigation Into Possible Securities Laws Violations by Pacific Biosciences of California, Inc. 2
... aptamer screening and binding optimization and built ... on-chip synthesis platform. These microarrays are available ... Microarray Service. Probe Content ... greater than 1500 known aptamer sequences. Add ...
... mouse embryonic stem cells to dopaminergic neurons. ... where they are mainly located in the ... the retrorubral field. These dopaminergic (DA) neurons ... ( e.g.projections to the caudate nucleus, putamen ...
... aptamer screening and binding optimization and built ... on-chip synthesis platform. Thousands of customer specified ... LC Sciences can provide assistance with custom ... part of our comprehensive DNA/RNA Aptamer Microarray ...
... Microarrays designed for DNA aptamer screening ... flexible and powerful Paraflo microfluidic on-chip synthesis ... be synthesized on-chip and LC Sciences can ... microarrays are available as part of our ...
Biology Products: