Navigation Links
New route to identify drugs that can fight bacterial infections
Date:7/28/2014

isrupt the intracellular growth of four bacterial strains: Coxiella burnetii (which causes Q fever), Legionella pneumophila (Legionnaires' disease), Brucella abortus (brucellosis), and Rickettsia conorii (Mediterranean spotted fever). Although none of these organisms have become problem infections in the U.S. due to antibiotic resistance, brucellosis and Q fever can both cause chronic and ultimately fatal disease in about 5% of those infected.

The team screened each drug for its ability to reduce intracellular bacterial growth by 80% or more inside human THP-1 macrophage-like immune cells. They eliminated drugs from the list that simply killed off the human host cells or that were known antibiotic or antiviral drugs and identified 101 drugs that presumably disrupt key cellular functions in the host cells.

Shuman's lab group did the experiments on C. brunetii and L. pneumophila, while Sean Crosson's group at University of Chicago carried out the B. abortus work, and Juan Martinez's group, now at Louisiana State University in Baton Rouge, performed the R. conorii studies. The work, which was done at the Howard T. Ricketts Laboratory, a biocontainment laboratory operated by the University of Chicago in Lemont, Illinois, shows that known drugs that interfere with host cell properties can stall intracellular bacterial infections.

"There are emerging infections of all sortsbacteria, viruses, parasites. Working up a new therapy for such things take time," says Shuman. "If we have drugs X, Y, or Z to interfere with host cell functions to slow or impede an infection, then we can have something already on hand to attack it."


'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. How bumblebees find efficient routes without a GPS
2. A better route to xylan
3. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
4. Transmission routes of spreading protein particles
5. A fly mutation suggests a new route for tackling ALS
6. Antibiotics: Change route of delivery to mitigate resistance
7. A route for steeper, cheaper, and deeper roots
8. UT Arlington nanoparticles could provide easier route for cell therapy
9. Study provides insights into birds migration routes
10. Beyond the microscope: Identifying specific cancers using molecular analysis
11. Researchers identify new regulator in allergic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 2015 According to a ... Market Forecast & Opportunities, 2020", the global biometrics market ... 14% till 2020. The biometrics market is garnering ... and review of biometric management systems. The constant ... with greater efficiency, are resulting in increasing installation ...
(Date:4/6/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... focused on the growing mobile commerce market, announced ... for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM ... NXT-ID introduces a new revolutionary method and system ... use of miniature antenna modules for multiple purposes ...
(Date:4/1/2015)... Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces the ... wallets is underway to early access pre-order customers. ... usage at retail outlets including Walmart, Target, AT&T, Dunkin, ... Wocket was accepted at all outlets and very easy ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... the vast, empty tundra in Alaska and Canada giving ... southerly climates. Imagine similar changes in large parts of ... broadleaf forests push northward into areas once unable to ... thought permanent, receding and leaving new tundra in its ...
... (Santa Barbara, Calif.) Simply by eating the leaves of ... beetle may help to slow down water loss in the ... working with colleagues from the U.S. Geological Survey and the ... showing water savings that can result from using Asian beetles ...
... A Purdue University scientist and researchers in Japan have ... that are expected to be less toxic to humans. ... growth inhibitors block the transport of auxin, a plant ... processes. Current growth regulators that inhibit auxin transport are ...
Cached Biology News:Shrinking tundra, advancing forests: how the Arctic will look by century's end 2Shrinking tundra, advancing forests: how the Arctic will look by century's end 3Scientists study control of invasive tree in western US 2Scientists study control of invasive tree in western US 3New growth inhibitors more effective in plants, less toxic to people 2
(Date:4/28/2015)... Denmark , April 28, 2015  DanDrit Biotech ... biotechnology company developing a vaccine for the treatment of ... signed a final collaboration agreement with GISCAD Foundation, a ... tract cancer studies. The collaboration relates to ... in patients with no evidence of disease (NED) Stage ...
(Date:4/28/2015)... 2015  US-Australian drug discovery company, Novogen Limited (ASX: ... a letter from NASDAQ informing it that it had ... Rule). In November 2014, the Company ... to submit a plan to regain compliance with the ... $2,500,000 in stockholders, equity as of June 30, 2014; ...
(Date:4/28/2015)... 28, 2015 IMS is releasing ... it to the web and provide greater accessibility ... friendly reporting metrics increase data warehouse’s utility; plus, ... recall and access “on-the-go” makes data analysis even ... client feedback to assist in repository analytics and ...
(Date:4/28/2015)... 28, 2015 Spartan Bioscience today announced ... been selected by the Ottawa Chamber of Commerce as ... Lem was selected from over 240 applicants based on ... Prior to Spartan, Dr. Lem founded Plexagen Diagnostics, and ... He holds a Medical Degree from the University of ...
Breaking Biology Technology:DanDrit Biotech USA, Inc. Announces Final Collaboration Agreement with the GISCAD Foundation 2DanDrit Biotech USA, Inc. Announces Final Collaboration Agreement with the GISCAD Foundation 3DanDrit Biotech USA, Inc. Announces Final Collaboration Agreement with the GISCAD Foundation 4Novogen Regains Full Compliance with NASDAQ Listing Rule 2Novogen Regains Full Compliance with NASDAQ Listing Rule 3Spartan Bioscience Announces Paul Lem Named Ottawa’s Top 40 Under 40 2
... , LEXINGTON, Ky. , ... based in Lexington, KY announced today that its ... created and characterized the world,s first rat model of severe ... complete lack of the major components of the immune system. ...
... 6 Omnio Healer AB, a pioneer company,developing novel ... has entered into a partnership agreement with Eden,Biodesign. Under ... production services relating to Omnio Healer,s lead,recombinant protein candidate. ... therapeutic concept for wound healing and,anti-infection, Omnio Healer is ...
... WALTHAM, Mass., Aug. 6 Repligen Corporation (Nasdaq: ... 2010, ended June 30, 2009. Total revenue for the quarter ... quarter of fiscal year 2009. The prior year results were ... Company for royalties on the U.S. sales of Orencia(R) prior to ...
Cached Biology Technology:Transposagen Creates a Rat Model of the Human Immune System 2Transposagen Creates a Rat Model of the Human Immune System 3Omnio Healer Selects Eden Biodesign for cGMP Production of its Candidate Wound Healing and Anti-Infection Treatments 2Omnio Healer Selects Eden Biodesign for cGMP Production of its Candidate Wound Healing and Anti-Infection Treatments 3Repligen Reports First Quarter Fiscal Year 2010 Financial Results 2Repligen Reports First Quarter Fiscal Year 2010 Financial Results 3Repligen Reports First Quarter Fiscal Year 2010 Financial Results 4Repligen Reports First Quarter Fiscal Year 2010 Financial Results 5Repligen Reports First Quarter Fiscal Year 2010 Financial Results 6Repligen Reports First Quarter Fiscal Year 2010 Financial Results 7
Human Ig Lambda-chain, clone ICO-16, Monoclonal Antibody...
Rabbit polyclonal to Warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to KLH...
WNV Core Antibody...
... Rabbit polyclonal to FANCM ( Abpromise ... Antigen: Synthetic peptide derived from ... Human FANCM. (Note: the amino acid ... available as ab27787 .) ...
Biology Products: