Navigation Links
New route to identify drugs that can fight bacterial infections
Date:7/28/2014

About 100 drugs already approved by the U.S. Food and Drug Administration (FDA) for other purposes can also prevent the growth of certain bacterial pathogens inside human cells, including those that cause Legionnaires' disease, brucellosis, and Mediterranean spotted fever. The findings, published in mBio, the online open-access journal of the American Society for Microbiology, demonstrate a new way of identifying non-antibiotic drugs that could one day help curb bacterial infections.

A handful of drugs on the list inhibit the growth of at least three of the four bacterial organisms tested. Those drugs include familiar compounds like loperamide, an antidiarrheal medication sold under the brand name Imodium and clemastine, an allergy medicine sold as Tavist, as well as drugs used to treat high blood pressure and angina.

Howard Shuman, professor of microbiology at the University of Chicago and a senior author on the study cautions that this study only looked at infection in the laboratory dish and therefore whether the drugs would effectively treat infections in humans is not known. The work, he says, is a good first step showing this method can identify FDA-approved drugs that might potentially act alongside traditional antibiotics.

"Antibiotic therapy is becoming more difficult to achieve, so looking for alternatives is always a good thing to do," Shuman says.

Shuman and his colleagues thought that certain types of bacteriathose that infect human cells and then replicate inside those cellsmight be vulnerable to other drug approaches.

"Intracellular bacteria resemble viruses in that they need host cell functions to complete their life cycle," says Shuman. So the researchers screened drugs to look for compounds that interfered with those cellular processes. They chose a panel of 640 FDA-approved drugs that have known safety and side effect profiles.

The researchers measured each drug's ability to d
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

Related biology news :

1. How bumblebees find efficient routes without a GPS
2. A better route to xylan
3. Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
4. Transmission routes of spreading protein particles
5. A fly mutation suggests a new route for tackling ALS
6. Antibiotics: Change route of delivery to mitigate resistance
7. A route for steeper, cheaper, and deeper roots
8. UT Arlington nanoparticles could provide easier route for cell therapy
9. Study provides insights into birds migration routes
10. Beyond the microscope: Identifying specific cancers using molecular analysis
11. Researchers identify new regulator in allergic diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... NEW YORK , Aug. 12, 2015 /PRNewswire/ ... how hackers can attack Android phones to steal ... identifies the increasing availability of fingerprint scanners on ... of utmost concern. To secure biometrics on mobile ... platform to augment these convenient authentication systems with ...
(Date:8/10/2015)... , August 10, 2015 ... Eye Tracking Technology for more than two decades, announces ... for integration into all consumer display formats. The SMI ... integration of eye tracking into consumer tablets, laptops, desktop ... smart glasses. Omnivision,s leading sensor technology contributes to the ...
(Date:8/6/2015)... and TELTOW, Germany , August ... Siggraph Conference, SensoMotoric Instruments (SMI) shows the ... , based on Epson,s Moverio BT-200 see-through ... platform. With this new solution, unprecedented quality and efficiency ... interaction with context-sensitive displays. For the first time, professionals ...
Breaking Biology News(10 mins):HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... the help of beneficial bacteria, plants can slam the door ... discovered. A scientific team under the leadership of Harsh ... College of Agriculture and Natural Resources, found that when pathogens ... in its leaves, a surprising ally comes to the rescue. ...
... updated Statement on Climate Change, replacing the 2007 version ... to provide a trustworthy, objective, and scientifically up-to-date explanation ... statement provides a brief overview of how and why ... continue to change in the future. It is based ...
... 27, 2012 Professional athletic field managers maintain trimmed ... colorful logos on their grass before each game. While ... field managers have noted deteriorating turfgrass beneath repeated paint ... study that appears in the September-October issue of ...
Cached Biology News:Behind closed doors: Researchers show how probiotics boost plant immunity 2Behind closed doors: Researchers show how probiotics boost plant immunity 3Athletic field paint steals spotlight from the grass it covers 2
(Date:8/31/2015)... ... August 31, 2015 , ... The Global Supply Chain Resiliency ... and resiliency practitioners with luminaries and thought leaders to advance the professional discipline ... their innovations and performance excellence. At that time its principle sponsor, Resilinc ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.20 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)... MARLBOROUGH, Mass. , Aug. 31, 2015 /PRNewswire/ ... biotechnology company focused on discovering and developing innovative ... ophthalmology, today announced that the 30-day review period ... Drug (IND) for ocular indications with the U.S. ... the IND is now active. ...
(Date:8/31/2015)... , Aug. 31, 2015 Trimb Healthcare ... agreement to acquire YouMedical Group BV ("YouMedical"), a Dutch ... has total annual sales of approximately EUR 16 million, ... "Our ambition is to build a ... important step toward that goal. YouMedical gives us a ...
Breaking Biology Technology:Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3Mexico Biomedical Sensors Market Report 2015-2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4
... MILWAUKEE - Miller Brewing Co. ... its sourcing processes, consolidate purchases across six U.S. ... those processes, Procuri announced. , ,Procuri, ... such as Blue Cross and Blue Shield Association, ...
... from the University of Wisconsin-Madison and an international consortium ... the first astronomical images obtained by the Southern African ... to the largest optical telescope in the world. , ... built the telescope on a remote mountain plateau, 220 ...
... Wis. -- One of the greatest agricultural and evolutionary ... the answer may lie in a plot of corn on ... new life to ancient genetic material. , ,While many biologists ... of maize, others believe that the differences between teosinte and ...
Cached Biology Technology:Single gene controls key difference between maize and its wild ancestor 2Single gene controls key difference between maize and its wild ancestor 3