Navigation Links
New roles emerge for non-coding RNAs in directing embryonic development
Date:8/28/2011

Scientists at the Broad Institute of MIT and Harvard have discovered that a mysterious class of large RNAs plays a central role in embryonic development, contrary to the dogma that proteins alone are the master regulators of this process. The research, published online August 28 in the journal Nature, reveals that these RNAs orchestrate the fate of embryonic stem (ES) cells by keeping them in their fledgling state or directing them along the path to cell specialization.

Broad scientists discovered several years ago that the human and mouse genomes encode thousands of unusual RNAs termed large, intergenic non-coding RNAs (lincRNAs) but their role was almost entirely unknown. By studying more than 100 lincRNAs in ES cells, the researchers now show that these RNAs help regulate development by physically interacting with proteins to coordinate gene expression and suggest that lincRNAs may play similar roles in most cells.

"There's been a lot of debate about what lincRNAs are doing," said Eric Lander, director of the Broad Institute and the senior author of the paper. "It's now clear that they play critical roles in regulating developmental decisions that is, cell fate. This was a big surprise, because specific types of proteins have been thought to be the master controls of development."

"This is the first global study of lincRNAs," said Mitchell Guttman, first author of the paper and a graduate student at MIT and the Broad Institute. "We picked embryonic stem cells in particular because they are so important to development and so well understood. This allowed us to dissect the role of lincRNAs within the circuitry of a cell."

The researchers used genetic tools to inhibit more than 100 lincRNAs and found that the vast majority more than 90 percent had a significant impact on embryonic stem cells, indicating that the RNAs play a key role in the cells' circuitry.

Embryonic stem cells can follow one of two main
'/>"/>

Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2

Related biology news :

1. Its good to have a shady side: sun and shade leaves play different roles in tree canopies
2. Molecular muscle: Small parts of a big protein play key roles in building tissues
3. Key plant hormone and its roles in plant biology is focus of new book
4. Biotech, nanotech and synthetic biology roles in future food supply explored
5. Small RNAs can play critical roles in male infertility/contraception
6. Illuminating life: How RNA, after a century in the shadows, emerged into the spotlight
7. Landsat 5 satellite helps emergency managers fight largest fire in Arizona history
8. Species reemergence after collapse: Possible but different
9. Mathematical model explains how complex societies emerge, collapse
10. Researchers discover human immune system has emergency backup plan
11. Ancient forest emerges mummified from the Arctic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... before humans figured out how to create colors, nature ... butterfly wings of many different hues, for example. Now ... more environmentally friendly way to make colored plastics. Their ... architectures of materials rather than dyes, to produce ... . , N. Asger Mortensen, Anders Kristensen and colleagues ...
(Date:7/30/2014)... has been awarded the Scientific Committee on Antarctic ... Research. , SCAR, an inter-disciplinary international science body, ... research in the Antarctic region, and on the ... system. The organisation also provides scientific advice about ... governing the region. , The medal is open ...
(Date:7/30/2014)... 3,000 pieces is still in its infant stage. But ... of major significance. "Amazingly often, we are findingin addition ... that we found in Baltic amber," explained Bonn paleontologist ... comes from the Baltic Sea region, which is almost ... e.g., the coastal regions of Mecklenburg, Poland and Belarus. ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... Bonn Institute for Forensic Medicine has recorded that the ... sexual offences within their catchment area increased 10-fold between ... Deutsches rzteblatt International, Burkhard Madea and Frank Musshoff ... for the most frequent substances ( Dtsch Arztebl Int ...
... should be built in Lund, Sweden, it has been announced ... last night (28 May), seven countries voted in support of ... a further two voting with the majority. The European ... for materials research, enabling scientists to study the atomic and ...
... of a USC-led research team say they,ve made a big ... and other biological materials one that may be a ... of a piece of synthetic antibody attached to a nanowire ... If the protein the antibody binds to is present in ...
Cached Biology News:Sweden to host 1.3 billion Euro research center 2A quicker, cheaper SARS virus detector -- one easily customizable for other targets 2
(Date:7/30/2014)... San Diego, CA (PRWEB) July 30, 2014 ... second contract from the U.S. Environmental Protection Agency ... company’s expertise in developmental toxicity models, including tests ... on neuron formation and the formation of connections ... function. Inhibition of neurodifferentiation and synapse formation by ...
(Date:7/29/2014)... July 30, 2014 SoundConnect ... collaboration company, is proud to announce the strategic ... positions in their Boston, Charleston and Atlanta offices. ... the increased demand for hosted solutions, collaboration and ... and reduce cost. , SoundConnect was founded in ...
(Date:7/29/2014)... 2014   Sequenom, Inc. (NASDAQ: ... genetic analysis solutions, and Mayo Medical Laboratories (MML), ... the United States , have announced ... applications. "We have great appreciation for Mayo ... we welcome the opportunity to partner with the organization,s ...
(Date:7/29/2014)... has created a new way of manufacturing microstructured ... made by self-assembly of carbon nanotubes, could exhibit ... mechanical stiffness and strength, or the ability to ... have demonstrated that mechanical forces can be used ... and that we can independently control the ...
Breaking Biology Technology:U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3SoundConnect Organization and Culture is Evolving 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4A new way to make microstructured surfaces 2
... June 16 On Wednesday, June 23 , a free, interactive ... renewed hope for new jobs in Ohio . Nine experts in the ... on innovation, global commerce and the new skills needed for a new economy ... , , ...
... Inc. (Nasdaq: NBIX ) announced today that the Company will host a ... worldwide development and commercialization of elagolix and the next-generation GnRH antagonists. , ... The live conference call and webcast will ... Eastern Time ( 5:45 a.m. Pacific Time ).  Participants can access the ...
... ... has announced the release of iC Kinetics software. iC Kinetics software ... a kinetic model that describes the influence of various experimental parameters ... be used to simulate the effect of concentration and temperature on ...
Cached Biology Technology:Free Web Cast On Fueling Ohio's New Job Growth 2Neurocrine Biosciences Announces Conference Call and Webcast on Worldwide Agreement With Abbott on Elagolix 2A Faster Way to Understand and Optimize your Chemistry 2