Navigation Links
New role for the JNK protein
Date:7/14/2010

LA JOLLA, Calif., July 14, 2010 Put simply, a tumor is the result of out-of-control cell growth. To assure that the cell cycle the cell's process of duplicating itself to make more cells goes smoothly, a large network of proteins tells other proteins what to do and when to do it. When any of these layers of protein regulation fail, cell growth can get out of hand. A new study led by Ze'ev Ronai, Ph.D., associate director of Sanford-Burnham's National Cancer Institute-designated Cancer Center, reveals a new player in cell cycle control. These findings, which appeared online in Nature Cell Biology on June 27, showed that JNK, a protein already well known for other duties, also regulates the cell cycle.

"This was totally unexpected of JNK," explained Gustavo Gutierrez, Ph.D., postdoctoral researcher in Dr. Ronai's laboratory and first author of the study. "We already knew that JNK helps cells respond to stress, such as damage caused by ultraviolet radiation. We thought we already knew how the major components of the cell cycle were regulated. This study really changes the thinking by connecting the two."

On the molecular level, JNK influences cellular functions by tagging other proteins with a phosphate chemical group (a process known as phosphorylation), a common mechanism cells use to turn enzymes on and off. Phosphorylation is so important that when JNK goes awry, a number of different disorders can result, such as cancer, diabetes or neurodegenerative diseases.

The part JNK plays in controlling the cell cycle is completely new. In this study, JNK activity was found to regulate the function of one of the major drivers of the cell cycle, a protein complex known as the APC/C. According to this, and related research recently published by Dr. Gutierrez and Dr. Ronai in the Journal of Biological Chemistry, JNK acts like an assembly line inspector; its presence and activity ensures that the cell cycle moves along smoothly. Any problems push JNK to halt the process at certain 'checkpoints.' If all systems look good, the cell cycle progresses. If not, minor damage is fixed or, if beyond repair, the whole process is scrapped.

"Certain situations where JNK is hyperactive, as seen in some human tumors, might also influence the cell cycle and promote genomic instability," said Dr. Ronai. "Our laboratory is now assessing this possibility using a mouse model that was engineered based on these new discoveries."


'/>"/>

Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Related biology news :

1. Supercharged proteins enter biologys forbidden zone
2. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
3. New retrieval method makes studying cancer proteins easier
4. Rice program takes on protein puzzle
5. Pitt researchers find new proteins that regulate blood pressure, flow
6. Map of herpes virus protein suggests a new drug therapy
7. TGen finds protein inhibitor revives chemotherapy for ovarian patients
8. CSHL team shows how loss of key protein promotes aggressive form of leukemia
9. Technique enables precise control of protein activity in living cells
10. Carbon nanotubes form ultrasensitive biosensor to detect proteins
11. Gestational diabetes linked to serotonin and dietary protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Avanade is helping Williams Martini Racing, one of ... biometric data in order to critically analyse every aspect ... against their rivals after their impressive, record-breaking pit stop ... with Williams during the 2016 season to capture and ... rate, temperature and peak acceleration) for key members of ...
(Date:12/5/2016)... -- The Office of Justice Programs, National Institute of ... or Replace Medico Legal Autopsies?" on NIJ.gov.  The ... forensic autopsies with postmortem X-ray computed tomography, commonly ... to recommendations made by The National Academy of ... a potential component of medicolegal death investigations. NIJ,s ...
(Date:11/29/2016)... , Nov. 29, 2016 BioDirection, a ... point-of-care products for the objective detection of concussion and ... company has successfully completed a meeting with the U.S. ... Tbit™ blood test Pre-Submission Package. During the meeting company ... system as a precursor to commencement of a planned ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... ... December 07, 2016 , ... Huffman Engineering, Inc. , ... Wonderware Certified System Integrator Partner. Huffman Engineering is the only Nebraska-based company ... System Integrator Partner certification gives customers confidence that our engineers are fully trained ...
(Date:12/7/2016)... Capital Corp. ("Zenith" or the "Company") announces webcast details for ... Annual and Special Meeting. The Zenith Annual ... December 15, 2016 at Mount Royal ... Royal Gate SW, Calgary, Alberta , commencing ... information circular, containing the matters to be considered at the ...
(Date:12/7/2016)... The report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, Injection Molding), ... 2026", published by MarketsandMarkets, the global market size was USD 645.4 Million in ... of CAGR of 6.2% between 2016 and 2026. ... ... , , ...
(Date:12/7/2016)... -- Muse bio, a privately-held company leading the development of ... Kevin Ness has been appointed Chief Executive Officer ... Kevin succeeds Muse bio,s founding CEO Ryan ... as well as remains Slade Professor, Chemical and Biological ... the RAS Energy Institute at the University of Colorado, ...
Breaking Biology Technology: