Navigation Links
New role for the JNK protein
Date:7/14/2010

LA JOLLA, Calif., July 14, 2010 Put simply, a tumor is the result of out-of-control cell growth. To assure that the cell cycle the cell's process of duplicating itself to make more cells goes smoothly, a large network of proteins tells other proteins what to do and when to do it. When any of these layers of protein regulation fail, cell growth can get out of hand. A new study led by Ze'ev Ronai, Ph.D., associate director of Sanford-Burnham's National Cancer Institute-designated Cancer Center, reveals a new player in cell cycle control. These findings, which appeared online in Nature Cell Biology on June 27, showed that JNK, a protein already well known for other duties, also regulates the cell cycle.

"This was totally unexpected of JNK," explained Gustavo Gutierrez, Ph.D., postdoctoral researcher in Dr. Ronai's laboratory and first author of the study. "We already knew that JNK helps cells respond to stress, such as damage caused by ultraviolet radiation. We thought we already knew how the major components of the cell cycle were regulated. This study really changes the thinking by connecting the two."

On the molecular level, JNK influences cellular functions by tagging other proteins with a phosphate chemical group (a process known as phosphorylation), a common mechanism cells use to turn enzymes on and off. Phosphorylation is so important that when JNK goes awry, a number of different disorders can result, such as cancer, diabetes or neurodegenerative diseases.

The part JNK plays in controlling the cell cycle is completely new. In this study, JNK activity was found to regulate the function of one of the major drivers of the cell cycle, a protein complex known as the APC/C. According to this, and related research recently published by Dr. Gutierrez and Dr. Ronai in the Journal of Biological Chemistry, JNK acts like an assembly line inspector; its presence and activity ensures that the cell cycle moves along smoothly. Any problems push JNK to halt the process at certain 'checkpoints.' If all systems look good, the cell cycle progresses. If not, minor damage is fixed or, if beyond repair, the whole process is scrapped.

"Certain situations where JNK is hyperactive, as seen in some human tumors, might also influence the cell cycle and promote genomic instability," said Dr. Ronai. "Our laboratory is now assessing this possibility using a mouse model that was engineered based on these new discoveries."


'/>"/>

Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

Related biology news :

1. Supercharged proteins enter biologys forbidden zone
2. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
3. New retrieval method makes studying cancer proteins easier
4. Rice program takes on protein puzzle
5. Pitt researchers find new proteins that regulate blood pressure, flow
6. Map of herpes virus protein suggests a new drug therapy
7. TGen finds protein inhibitor revives chemotherapy for ovarian patients
8. CSHL team shows how loss of key protein promotes aggressive form of leukemia
9. Technique enables precise control of protein activity in living cells
10. Carbon nanotubes form ultrasensitive biosensor to detect proteins
11. Gestational diabetes linked to serotonin and dietary protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 15.1% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... April 27, 2017  Pendant Biosciences, Inc. (formerly Nanoferix, ... modification and drug delivery technologies, today announced that it ... @ Toronto . ... Pendant Biosciences, noted, "We are excited to become part ... community, and are honored to be the first ...
(Date:4/26/2017)... ... 26, 2017 , ... Looking for gift ideas for mom ... offers one-of-a-kind gifts, ranging from gourmet cooking experiences to Farmer’s Market Tours and ... inspired with new cooking tips and techniques, thanks to Chef Jodi Abel’s expertise ...
(Date:4/26/2017)... ... April 26, 2017 , ... Led by ex-FDA official ... trials comes to Tampa, San Francisco and Boston in 2017. The 2016 ... organizations such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., Ocular Therapeutix Inc., Cell ...
(Date:4/26/2017)... ... April 26, 2017 , ... Baltimore bio tech firm, PathSensors, ... screening solution at the National Postal Forum 2017 in Baltimore, Maryland, May 21st ... accurate, easy to use and low cost threat detection solution for government and ...
Breaking Biology Technology: