Navigation Links
New risk factor identified for high blood pressure during pregnancy
Date:11/26/2012

oblasts are key contributors to spiral-artery remodeling and thus ensure that the fetus is sufficiently supplied with nutrients. However, if the trophoblasts do not grow deeply enough into the decidua, this remodeling process is disturbed. As a consequence, the fetus cannot be sufficiently supplied with nutrients, leading to preeclampsia. EETs evidently have a harmful effect because they activate a substance which prevents the trophoblasts from growing into the decidua.

Both a protective and damaging effect

Previous studies indicated that EETs exert only positive effects on the cardiovascular system. EETs generally mediate vascular expansion and reduce blood pressure. They also protect the tissue from dying of oxygen deficiency. In normal pregnancies EET levels are slightly elevated.

Previous experiments with healthy pregnant rats showed that pharmacological inhibition of the CYP2J2 enzyme and the associated inhibition of EET production lead to hypertension and kidney failure. In pregnant rats with preeclamptic symptoms, however, opposite effects may occur. By inhibiting CYP2J2, the ECRC researchers were able to lower blood pressure levels in these animals.

How did these conflicting observations come about? Dr. Herse and team demonstrated that the EETs can be converted into other metabolites. A specific enzyme (cyclooxygenase, COX) alters these components further in such a way that they cause vasoconstriction and thus an increase in blood pressure. EETs that normally lower blood pressure can evidently produce metabolites that cause blood pressure to rise in preeclampsia. If however the researchers inhibited the cyclooxygenase in the pregnant animals, the EETs were not converted further and the blood pressure did not increase. "This work shows that the increased production of EET in the placenta and the conversion via cyclooxygenase into hormones that increase blood pressure both favor the development of preeclampsia," Dr. Herse
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Studies in Cell Transplantation investigate oxygens impact as a factor in transplantation
2. Microscopic packets of stem cell factors could be key to preventing lung disease in babies
3. Social factors trump genetic forces in forging friendships, CU-led study finds
4. Stay-at-home transcription factor prevents neurodegeneration
5. Forest killer plant study explores rapid environmental change factors
6. Swim training plus healthy diet factor in cancer fight: New study
7. Johns Hopkins researchers link 2 biological risk factors for schizophrenia
8. U of S researchers discover cannabis pharma factory
9. True blood: SLU scientist investigates clotting factors
10. American Society for Microbiologys newest journal earns a high impact factor in latest rankings
11. Transcription factor Lyl-1 critical in producing early T-cell progenitors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)...  Valencell, a leader in performance biometric data sensor ... from its licensees for highly accurate, clinically validated biometric ... coming from fitness and health sectors, but first responders/military ... is only as useful as the biometric data it ... in long-term mass consumer adoption of wearable products," said ...
(Date:12/10/2014)... December 9, 2014   ... Platform   Jifflenow, ... scheduling solutions for business-to-business (B2B) events, today announced ... in mobile near-field communication (NFC), Bluetooth low energy ... (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate ...
(Date:12/3/2014)...   Marvin Test Solutions , a trusted ... military, aerospace, and manufacturing organizations, today announced the ... TS-900 PXI semiconductor test platform . The TS-960 ... to customers at a fraction of the footprint ... "Our semiconductor customers asked for ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... Lugano-CH, Brussels- BE, 2 May 2013 -- An important ... precisely how much measurement variation influences gene expression profiles ... first time, which gene expression measurements may benefit from ... at the 5th IMPAKT Breast Cancer Conference in Brussels, ...
... healthy people have been bombarded by stories in the media ... vitamin D levels, and urging high doses of supplements to ... to diabetes. But new research from Johns Hopkins finds ... the top of the range suggested by the Institute of ...
... PLOS, the Public Library of Science, today is launching ... use of scientific research, published through Open Access, which ... society. Major sponsors include the Wellcome Trust and Google. ... applied or remixed scientific research to innovate and make ...
Cached Biology News:Study reveals magnitude of variation in gene expression measurements within breast cancers 2Study reveals magnitude of variation in gene expression measurements within breast cancers 3Vitamin D: More may not be better 2PLOS announces Accelerating Science Award Program 2
(Date:12/19/2014)... Dec. 19, 2014  Roche (SIX: RO, ROG; OTCQX: ... Inc. (Bina), a privately held company based in ... Bina provides a big data platform for centralized ... data. Bina,s proprietary on-market Genomic Management Solution, Bina-GMS ... to perform fast and scalable analyses to maximize ...
(Date:12/19/2014)... 2014 Decision Resources Group finds that the ... 12 percent compound annual growth rate through 2023. This ... and the increasing adoption of dental implants. Growing aesthetic ... also spur demand for dental biomaterials because they can ... treatments. Other key findings from Decision Resources ...
(Date:12/19/2014)... 18, 2014 BioPlus Specialty ... specialty pharmacies, has an expanded team of Regional ... consultants for prescriber offices in their regions, with ... “We have a variety of Regional Pharmaceutical Care ... specializing in hepatitis C help prescribers understand all ...
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 LayerBio ... for ophthalmology and wound care. The National Eye Institute ... awarded LayerBio a Phase I SBIR grant to develop ... Cataracts are the most common cause of vision loss ... of blindness worldwide. According to Dr. Ken Mandell, LayerBio’s ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... LONDON, January 23, 2012 Representatives of ... new regulatory landscape as well as provide the feedback ... th   Annual Cool Chain Logistics Europe, ... Basel, Switzerland. Over 400 attendees including senior ...
... (NYSE: DGX ), the world,s leading provider ... the U.S. Food and Drug Administration (FDA) has granted ... STRATIFY JCV ™ Antibody ELISA testing service. STRATIFY ... market authorized for the qualitative detection of antibodies to ...
... 2012  Waters Corporation (WAT:NYSE) and Ireland,s National ... announced today the availability of the world,s first ... Chromatography ® (UPLC®). Developed by Professor Pauline ... GlycoBase 3+ Database is the first-of-its-kind ...
Cached Biology Technology:Quest Diagnostics STRATIFY JCV™ First FDA Market Authorized Antibody-based Blood Test to Help Stratify PML Risk in Multiple Sclerosis Patients 2Quest Diagnostics STRATIFY JCV™ First FDA Market Authorized Antibody-based Blood Test to Help Stratify PML Risk in Multiple Sclerosis Patients 3Waters and NIBRT Complete Work on World's First UPLC Glycan Database 2Waters and NIBRT Complete Work on World's First UPLC Glycan Database 3