Navigation Links
New resource to unlock the role of microRNAs
Date:8/7/2011

A new resource to define the roles of microRNAs is announced today in Nature Biotechnology. The resource, called mirKO, gives researchers access to tools to investigate the biological role and significance for human health of these enigmatic genes.

mirKO is a "library" of mutant mouse embryonic stem (ES) cells in which individual, or clustered groups of microRNA genes, have been deleted. Using these tools researchers can create cells or mice lacking specific microRNAs, study expression using fluorescent markers, or inactivate the gene in specific tissues or at specific times in development. This is the first mammalian microRNA knockout resource; the only other comprehensive resource of mutated microRNA genes is that for the nematode worm.

microRNAs first named only ten years ago are encoded by more than 500 genes that are predicted to regulate about one third of protein-coding genes. Consisting of short stretches of 21 to 23 nucleotides, microRNAs act by interfering with the activity of messenger RNAs. Studies over the past five years have shown that microRNAs are likely to play important roles in disease such as cancer and disorders of the heart, the immune system and auditory systems.

"We have generated a resource of microRNA knockout alleles in mouse ES cells that are standardized with respect to design and genetic background that researchers can access through repositories," says Dr Haydn Prosser, lead author on the research from the Wellcome Trust Sanger Institute. "In many cases, microRNAs with overlapping messenger RNA target specificities occur at multiple locations throughout the genome. To address these complexities a comprehensive resource is valuable to enable the creation of compound mutants in cells or mice."

The first step was to develop DNA vectors to target the microRNA genes: the team produced two alternative vectors that could, if desired, be used to knock out both copies of a particular microRNA
'/>"/>

Contact: Don Powell
press.office@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. SIB launches next generation ExPASy, an entry portal to indispensable bioinformatics resources
2. Madagascar marine resources plundered by international seafood markets
3. New project will collect vital knowledge about tree genetic resources to support conservation
4. Surprise! Biodiversity and resource use may co-exist in tropical forests
5. Recycling perlite: New, improved method saves resources
6. Elsevier and the Arabidopsis Information Resource connect research articles
7. 3-D digital dinosaur track download: A roadmap for saving at-risk natural history resources
8. Restructuring natural resource majors
9. New user-friendly resource connects human genes to biological functions
10. American Chemical Society posts new online collection of resources on climate change
11. Resource restoration planning process begins for BP/Deepwater Horizon oil spill
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... from The Chinese University of Hong Kong, BGI and ... linked to salt tolerance, with implication for improving this ... published online in Nature Communications provides an ... improvement. , Soybean is an important crop for the ... have less genetic diversities than their wild counterparts. Among ...
(Date:7/11/2014)... other group members to reduce aggression and gain access ... for grooming activities shows a certain pattern across the ... journal Biology Letters . , Grooming between individuals ... ulterior motives. To be groomed has hygienic benefits and ... individual can provide access to infants, mating opportunities and ...
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... body's molecules controls the trafficking of T cells through the ... -- a crucial response that sometimes goes awry, attacking the ... control system -- composed of a fat-like compound called S1P ... cells from launching harmful reactions. But when the S1P traffic ...
... gene mutation that identifies the lung cancer patients most likely ... with a response to the drug cetuximab (Erbitux), according to ... the Journal of the National Cancer Institute. Both ... , Some patients with non?small-cell lung cancer (NSCLC) have mutant ...
... evidence that olfaction is uniquely a "dual" sense, in that ... arrives through the nose rather than the mouth. In the ... that the smell of chocolate activated different brain regions according ... through the mouth or through the nose. , In a ...
Cached Biology News:Discovery of T-cell 'traffic control' boosts new drug promise 2Discovery of T-cell 'traffic control' boosts new drug promise 3Discovery of T-cell 'traffic control' boosts new drug promise 4Treatments have same target, different responses for lung cancer patients with genetic mutation 2Nose odors and mouth odors: The brain distinguishes 2Nose odors and mouth odors: The brain distinguishes 3
(Date:7/10/2014)... Toronto, Canada (PRWEB) July 10, 2014 ... often present in very low abundance and are ... quite challenging and time-consuming. , Join presenters Dr. ... Laboratories, and Dr. John Anders, Head of Quality ... mass spectrometer-based approach that can speed detection and ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Robert Harman, ... Veterinary Medicine company, is proud to announce the relaunch of ... launching with a new series called “ What are Stem ... give an honest and straightforward foundation in the basics of ... educated decision on the right type of treatment when considering ...
(Date:7/10/2014)... On July 9 Prime Minister ... Russia,s first national "Industry" award ... is developing a unique project called MabNext . ... number of innovative drugs based on monoclonal antibodies for ... place at the International Exhibition "Innoprom 2014" in Ekaterinburg. ...
(Date:7/10/2014)... 2014 -- According to the International Atomic Energy ... comes from terrorists acquiring sufficient quantities of plutonium ... crude nuclear explosive device. The IAEA also notes ... involved gram-level quantities, which can be challenging to ... a new study appearing this week in the ...
Breaking Biology Technology:Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Sensitive detection method may help impede illicit nuclear trafficking 2
... Pharmaceuticals, Inc., a,vertically integrated cGMP contract development ... Wood as Vice President, Business,Development. Ms. Wood ... including guiding Stason,s global business development,activities. Ms. ... experience in,sales, marketing, business and strategic planning, ...
... British Columbia researchers has developed a technique that controls ... superconductors, a procedure considered impossible for the past two ... the team deposited potassium atoms onto the surface of ... the scientists to continuously manipulate the number of electrons ...
... for Metabolic and Bariatric Surgery ... ... USGI Medical Inc. (USGI),announced today that leading experts presented clinical evidence ... an incisionless technique to reduce the size of the,gastric pouch and ...
Cached Biology Technology:Stason Pharmaceuticals, Inc. Appoints Diana Wood as Vice President, Business Development 2UBC physicists develop 'impossible' technique to study and develop superconductors 2Studies Show USGI Medical's EndoSurgical Operating System(TM) Enables Incisionless Surgery to Reduce Gastric Pouch and Stoma After Gastric Bypass 2
b-Catenin (pSer675), phospho-specific...
BDFastImmune? IFN-gamma /CD69/CD4/CD3 Storage Temperature: Refrigerate(2 to 8C)...
PKC (pSer345), phospho-specific...
Rabbit polyclonal to IRS1 (phospho S636) ( Abpromise for all tested applications). entrezGeneID: 3667 SwissProtID: P35568...
Biology Products: