Navigation Links
New resource opens the door for enzyme research
Date:2/27/2012

The European Molecular Biology Laboratory's European Bioinformatics Institute has launched the Enzyme Portal, a freely available resource for people who are interested in the biology of enzymes and proteins with enzymatic activity.

Enzymes catalyse the myriad reactions that take place in living organisms, allowing chemical changes to occur that would otherwise need conditions that are incompatible with life. Until now, information about enzymes was scattered throughout many different resources. This meant that you had to know exactly what you were looking for, which could be a real barrier to discovery.

The Enzyme Portal mines and displays data about proteins with enzymatic activity from public repositories via a single search, and includes biochemical reactions, biological pathways, small molecule chemistry, disease information, 3D protein structures and relevant scientific literature. It summarises information in the UniProt knowledge base; the Protein Data Bank in Europe; Rhea, a database of enzyme-catalysed reactions; Reactome, a database of biochemical pathways; IntEnz, a resource with enzyme nomenclature information; ChEBI and ChEMBL, which contain information about small-molecule chemistry and bioactivity; and CoFactor and MACIE for highly detailed, curated information about cofactors and reaction mechanisms.

The Enzyme Portal covers a large number of species, including the key organisms used in biological research, and makes it simple to compare the characteristics of equivalent enzyme activities in different organisms.

"The Enzyme Portal will serve researchers interested in the native metabolism of organisms as well as those working in drug discovery or chemical biology," explained Dr Christoph Steinbeck, Head of Cheminformatics and Metabolism at EMBL-EBI. "The resource seamlessly bridges the various enzyme-related aspects of these areas, all the way from the small molecules which may occur naturally in the organism of study or be introduced to the 3D structure of the enzymes affected and the genomic information coding for those."

The design of the Enzyme Portal was based entirely on user demand and feedback. "We didn't come in with preconceived ideas of what it should be; it was designed by users, for users," said Cheminformatics Coordinator Paula de Matos. "We had enough data, but it was distributed over 10 different resources. Now, we have a central place where they can access and explore all of it including information about disease."

"The Enzyme Portal takes the researcher's perspective," added User Experience Analyst Jenny Cham. "We leveraged user-testing feedback to create it, making it the first EMBL-EBI resource to have a fully user-centred design from scratch. This approach was not only cost-effective; it made decision making and communication much easier particularly in terms of design and technology choices."


'/>"/>

Contact: Mary Todd Bergman
contactpress@ebi.ac.uk
44-122-349-4665
European Molecular Biology Laboratory - European Bioinformatics Institute
Source:Eurekalert  

Related biology news :

1. Engineers improve allocation of limited health care resources in resource-poor nations
2. Wild west approach to claiming the oceans genetic resources must end: UBC media release
3. North Carolina-based genetic resources fuel big scientific progress
4. New mouse collaborative cross resource promises new cures and treatments for diseases
5. Open access: Comprehensive occupational health and safety resource now available online
6. Eyeing resources, India, China, Brazil, Japan, other countries want a voice on Arctic Council
7. Global resource for clinical microbiologists and immunologists debuts
8. Mite-y genomic resources for bioenergy crop protection
9. Effects of climate change to further degrade fisheries resources: UBC researchers
10. NOAA releases status on Florida Keys National Marine Sanctuary marine resources
11. 3-D microscope opens eyes to prehistoric oceans and present-day resources
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New resource opens the door for enzyme research
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
(Date:3/31/2016)... PROVIDENCE, R.I. , March 31, 2016  Genomics ... leadership of founding CEO, Barrett Bready , M.D., ... addition, members of the original technical leadership team, including ... Vice President of Product Development, Steve Nurnberg and Vice ... have returned to the company. Dr. Bready ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... , May 19, 2016 ... una sessione orale durante il 52 ° ... n. 8006)    - Le conclusioni dello ... riguarda i pazienti trattati, di cui il 90% presenta una ... sei mesi o più. Il settantadue per cento dei pazienti ...
(Date:5/18/2016)... ... May 18, 2016 , ... ... Camp at The University of Toledo. This two-day camp will take place annually ... explore the field of pharmaceutical sciences in preparation for a university academic program. ...
(Date:5/18/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... kit processing to help them save time and reduce errors. , Sexual Assault kits ... processed and victims informed of results. Due to a previous lack of tools, many ...
(Date:5/18/2016)... (PRWEB) , ... May 18, 2016 , ... The Academy ... is now celebrating its dream of reaching a total of $1 million in awarded ... awarded to 10 high school graduates from across the nation has helped bring the ...
Breaking Biology Technology: