Navigation Links
New research shows weekend binge drinking could leave lasting liver damage
Date:5/1/2013

Long after a hangover, a night of bad decisions might take a bigger toll on the body than previously understood. Described in the current issue of Alcoholism: Clinical & Experimental Research, a study at the University of Missouri has revealed a unique connection between binge drinking and the risk for developing alcoholic liver disease and a variety of other health problems.

"In our research, we found that binge drinking has a profound effect on the liver in various modes of alcohol exposure," said Shivendra Shukla, PhD, Margaret Proctor Mulligan Professor at the University of Missouri School of Medicine and corresponding author of the study. "No longer can we consider chronic alcohol consumption as the only factor in developing alcoholic liver disease."

Shukla said it's important to note there will be more liver injury in a chronic alcoholic if that person binge drinks, but a binge drinker may sensitize the liver over a longer period and make it prone to more damage. MU researchers studied the effects of binge drinking when coupled with chronic alcohol consumption and also in isolated cases of binge drinking not associated with chronic alcohol consumption.

Nationwide and in Missouri, binge drinking is on the rise. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) defines binge drinking for women as having four or more drinks in two hours; for men, it is five or more drinks in two hours. An estimated 29 percent of women and 43 percent of men have reported experiencing at least one binge drinking episode over the course of a year.

Through their study of alcohol exposure in rats, researchers in Shukla's lab found binge drinking amplifies injury to the liver when there was pre-exposure due to chronic alcohol consumption. As the main metabolic site for the body, the liver affects many systems in the body, including nutrient and drug metabolism and distribution, as well as the production of multiple agents that are needed for the heart, kidney, blood vessels and brain to function properly.

"Binge drinking should not be associated with only liver damage," said Shukla, a professor of medical pharmacology and physiology. "It creates an inflammatory response in the liver that is like a cluster bomb, sending out various damaging signals to systems in the body. If those organs are working at a lower level of function, then a whole host of physiological processes is affected."


'/>"/>

Contact: Laura Gerding
gerdingla@health.missouri.edu
573-882-9193
University of Missouri School of Medicine
Source:Eurekalert

Related biology news :

1. Synthetic biology research community grows significantly
2. Researchers pinpoint upper safe limit of vitamin D blood levels
3. European support for the first network of research and training in political ecology
4. Researchers track singing humpback whales on a Northwest Atlantic feeding ground
5. Huddersfield researchers publish a book exploring the link between evolution and criminal behavior
6. Research spinoff ReXceptor gets license for Alzheimers treatment
7. New research projects to enhance bioinformatics and computational biology tools and methodologies
8. Researchers pinpoint how trees play role in smog production
9. CNIO researchers capture the replication of the human genome for the first time
10. Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
11. Scientists awarded $5.5 million for wheat, rice blast research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys ... founding CEO, Barrett Bready , M.D., who returned ... of the original technical leadership team, including Chief Technology ... of Product Development, Steve Nurnberg and Vice President of ... to the company. Dr. Bready served as ...
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading ... the Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio ... and clinical trial team. , Using the CONSULT module, patients and physicians can schedule ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... - FACIT has announced the creation of a ... Propellon Therapeutics Inc. ("Propellon" or "the Company"), to ... of first-in-class WDR5 inhibitors for the treatment of ... an exciting class of therapies, possessing the potential ... patients. Substantial advances have been achieved with the ...
Breaking Biology Technology: