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New research shows obesity is an inflammatory disease
Date:12/2/2013

ived macrophages (HMDM), human and rodent adipocytes, and diet-induced obesity in rats. Oral treatment of diet-induced obese rats attenuated PAR2 signaling in adipose tissue and inhibited adipose inflammation, insulin resistance, diet-induced obesity and cardiovascular abnormalities. This is the first report that a PAR2 antagonist improves obesity, glucose homeostasis and obesity-associated chronic inflammation in vivo. These findings indicate that increased PAR2 expression may be a valuable new biomarker for metabolic dysfunction and further, that PAR2 antagonism can be an effective intervention for treating metabolic dysfunction and obesity.

"We know that that eating too much and not exercising enough makes you overweight, and then obese, but why? The bottom line of this report is that obesity is an inflammatory disease, and inflammation plays a greater role in the downward spiral to obesity than most people realize." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "It appears that once we can control the inflammation, we can begin to get everything else in line. Fortunately, these scientists have already identified one promising compound that seems to work."


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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

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