Navigation Links
New research shows no link between aromatase inhibitors and cardiovascular problems
Date:4/17/2008

Berlin, Germany: New evidence has emerged that, contrary to some current fears, aromatase inhibitors (AIs) are not associated with an increased risk of heart problems in women who take them to prevent their breast cancer recurring.

In a study presented today (Thursday) at the 6th European Breast Cancer Conference (EBCC-6) in Berlin, the researcher, Dr Alain Monnier, said that this was important and reassuring news for women.

AIs, such as letrozole, anastrozole and exemestane, work by causing severe oestrogen deprivation and, increasingly, they are being prescribed for women whose tumours are positive for the oestrogen receptor (ER+). Several trials have shown that AIs are more effective than tamoxifen the gold standard for ER+ tumours; however, concerns have been raised about their effects on the cardiovascular system. In particular, the consequences of oestrogen deprivation can be atherosclerosis, high levels of lipids (fats) in the blood (hyperlipidaemia), high cholesterol levels (hypercholesterolaemia) and consequent heart problems.

Dr Monnier, a medical oncologist and head of the medical oncology department at the Centre Hospitalier de Belfort-Montbliard (Belfort-Montbliard, France), looked at the results from several trials of AIs in order to compare the effects of AIs versus tamoxifen and placebos on lipid levels and heart problems.

One of the problems with obtaining clear evidence about the impact of AIs on cardiovascular health is that tamoxifen has cardioprotective effects, explained Dr Monnier. Tamoxifen is an anti-oestrogen with known lipid-lowering properties; it has been reported to reduce coronary plaques, C-reactive protein, and is associated with decreases in heart problems such as myocardial infarction. This makes comparisons between AIs and tamoxifen difficult to interpret, and so comparisons between AIs and placebos might indicate better the impact of AIs on cardiovascular health.

After looking at
'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Science expands Science Signaling, featuring research related to medical advances, and more
2. Researchers bridge the terahertz gap with new tunable metamaterial
3. NIST, Army researchers pave the way for anthrax spore standards
4. EPFL Research Day 2008, in the presence of Al Gore
5. UMass Medical School researcher Victor Ambros receives Gairdner Award, Franklin Medal
6. Improving care and knowledge in translational research to fight breast cancer
7. Researchers mimic bacteria to produce magnetic nanoparticles
8. Vitamin D and calcium influence cell death in the colon, researchers find
9. UD researchers discover novel gene toggles in worlds top food crop
10. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
11. Researchers close in on origins of main ingredient of Alzheimers plaques
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... developed a novel and versatile modeling strategy to simulate ... materials as well as for studying polyelectrolytes, including DNA ... model much larger and more complex polyelectrolyte systems, and ... lead author of a paper on the work and ... Science and Engineering. "This is a big step forward ...
(Date:8/20/2014)... ITHACA, N.Y. In a study of 158 pregnant ... the craving and intentional consumption of ice, cornstarch, ... items, reports a new Cornell study. , Moreover, such ... teens who did not eat nonfood substances. , Pregnant ... low hemoglobin, which can lead to iron deficiency and ...
(Date:8/20/2014)... Issue Serious allergic reactions to food ... for some children.    What you should know ... allergies and this number may be increasing, especially among children. ... have food allergies.  The symptoms of allergic ... breathing difficulties and loss of consciousness. Symptoms can also develop ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2Pica in pregnant teens linked to low iron 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... Spanish . , The potentially deadly yellow-fever-transmitting ... a compound called octenol as one way to find a ... scientists report. Scientists have long known that mosquitoes can ... Joseph Dickens and Jonathan Bohbot explains in greater detail how ...
... American Institute of Biological Sciences (AIBS) has selected Meredith ... Davis, Ryan Richards, a graduate student at the University ... student at the University of Rhode Island, to receive ... "AIBS is committed to fostering a productive ...
... Spring Harbor, NY -- One seemingly insurmountable obstacle to the ... wheat and rice is the dependence of those plants on ... and egg -- combine randomly to generate a genetically unique ... But what if plants like these could be engineered ...
Cached Biology News:ARS study provides a better understanding of how mosquitoes find a host 2AIBS names emerging public policy leaders 2AIBS names emerging public policy leaders 3CSHL-Mexican team coaxes sexually reproducing plant to brink of asexual reproduction 2
(Date:8/21/2014)... 21, 2014  Four-dimensional (4-D) printing develops materials ... external stimuli such as changes in temperature. This ... effect in multiple industries.  In the near future, ... printing objects ranging from human organs to parts ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
(Date:8/21/2014)... Ontotext S4 , The Self Service Semantic ... Now the same enterprise hardened text mining, Linked Data ... is available to start-ups and mid-size businesses at a ... do not have resources to evaluate and prototype enterprise ... there is no need for on premise hardware provisioning ...
(Date:8/21/2014)... August 21, 2014 SoundConnect ... been recognized as one of the nation’s Fastest ... magazine for the 2nd consecutive year. Inc. magazine ... annual Inc. 500|5000, an exclusive ranking of the ... most comprehensive look at the most important segment ...
(Date:8/20/2014)... Clintrax Global, Inc., a worldwide provider ... Raleigh, NC , recently announced the addition ... of Administration. As Vice President ... including their alignment with company objectives and policies.  ... an HR executive, specializing in needs assessments, customer ...
Breaking Biology Technology:Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 2SoundConnect Returns on Inc. 5000 List of Fastest Growing Companies 3Clintrax Global, Inc. Announces Addition to Executive Team 2
... 14, 2012 AMPAC Fine Chemicals LLC (AFC), a ... APFC ), reports that it has joined Rx-360 ... biotech industry consortium that was founded by industry leaders ... and to assure the quality and authenticity of the ...
... 2012 Neuralstem, Inc. (NYSE Amex: CUR ) ... registered direct placement of 5,200,000 shares of common stock at ... with an exercise price of $1.02 per share and exercisable ... of five years. The company received aggregate gross proceeds of ...
... Ill., Feb. 13, 2012 Hospira, Inc.  (NYSE: ... injectable drugs and infusion technologies, today announced the hiring ... and compliance capabilities, including the appointment of Zena G. ... 2012. In this role, Ms. Kaufman will have overall ...
Cached Biology Technology:AMPAC Fine Chemicals Continues to Invest in Quality Systems 2AMPAC Fine Chemicals Continues to Invest in Quality Systems 3Neuralstem Announces Closing of $5.2-Million Registered Direct Offering 2Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 2Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 3Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 4Hospira Names Zena G. Kaufman Senior Vice President of Quality; Strengthens Quality and Compliance Capabilities With Addition of Top Industry Talent 5
... is used to perform runs with ... the Experion automated electrophoresis system. The ... simulated gel views and summarizes size, ... Results table. This software is for ...
... rolled steel with stove enamel coated (RAL 7035 ... Front, back and side windows ... lamps Internal adjustable tempered glass shelf ... Lighting 600 lux ...
...
... this set of Antibody Microarray slides ... a total of over 2100 spots,including ... control. Antibodies belonging to many important ... cycle progression, signal transduction and gene ...
Biology Products: