Navigation Links
New research shows how disease-causing parasite gets around human innate immunity
Date:8/30/2010

The need for a clearer understanding of how these parasites evade human immune systems is at the heart of a serious public health problem, Hajduk said. During the recent epidemics of African sleeping sickness, as many as half the occupants in some African villages were infected with trypanosomes. The geographical isolation of these villages and ongoing civil wars contributed to what many believe were the worst epidemics of sleeping sickness in five decades.

This led to the realization that many of the existing therapies now available to fight African sleeping sickness are often ineffective and have extreme toxicity, frequently causing death. Additionally, there is increasing evidence that while new therapeutics may cure the disease, long-lasting neurological damage can be caused by infection.

The World Health Organization reports that the recent introduction of aggressive population screening in rural areas and distribution of more effective drugs has dramatically reduced the number of deaths, however.

Several species of African trypanosomes infect non-primate mammals and cause important veterinary disease yet are unable to infect humans. The trypanosomes that cause human disease, Trypanosoma brucei gambiense and T. b. rhodensiense, have evolved mechanisms to avoid the native human defense molecules in the circulatory system that kill the parasites that cause animal disease.

Two of the major challenges faced by scientists studying human sleeping sickness have been the identification of the naturally occurring human defense molecules that are active against the trypanosomes causing animal disease, and the identification of the strategies used by the human sleeping sickness parasites to avoid the action of these molecules.

Human innate immunity against most African trypanosomes is mediated by a subclass of HDL (high density lipoprotein, which people know from blood tests as "good cholesterol") called trypanosome lytic f
'/>"/>

Contact: Stephen Hajduk
shajduk@uga.edu
706-583-5542
University of Georgia
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... NC Ancient DNA adds a twist to the story ... to be published April 21 in the journal Proceedings ... from the bones of chickens that lived 200-2300 years ago ... ago domestic chickens may have looked far different from the ... of the traits we associate with modern domestic chickens -- ...
(Date:4/18/2014)... led by a University of California, Riverside professor of ... Department of Defense grant to uncover fundamental design rules ... predictable design of light-weight, tough and strong advanced materials ... and animals, including the mantis shrimp, toucan and bamboo. ... over millions of years and coming up with design ...
(Date:4/17/2014)... inhibits RSV infection , Respiratory syncytial virus ... tract infections, generating life-threating illness in very young ... are limited. RSV enters host cells through the ... fusogenic bundle. Small interfering peptides that prevent bundle ... peptides are highly susceptible to degradation. In this ...
Breaking Biology News(10 mins):Ancient DNA offers clues to how barnyard chickens came to be 2Mantis shrimp, toucan and trilobite, oh my 2Mantis shrimp, toucan and trilobite, oh my 3JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6
... happened in 1973. Republican president Richard Nixon -- who the ... of quotas and restrictions" -- signed the Endangered Species Act ... issues -- and the rapid decline of charismatic creatures like ... the law 92-0. Sounding more Thoreauvian than Thatcherite, Nixon declared, ...
... boat owner recognises the dilemma: environmentally friendly or effective. ... a way of reconciling these two almost unattainable aims. ... biocides in the paint, it is possible to both ... the environmental impact. "It,s very easy to make ...
... Building on its extensive laboratory research using magnetically ... The Children,s Hospital of Philadelphia has just spun off ... By licensing its technology to VMI, a new company ... viable therapy, the Hospital aims to create a novel, ...
Cached Biology News:Dispatches from the edge of doom 2Dispatches from the edge of doom 3Dispatches from the edge of doom 4More effective and less risky when you paint the hull of your boat 2CHOP partners with Vascular Magnetics, Inc. to pursue commercial potential of blood vessel research 2CHOP partners with Vascular Magnetics, Inc. to pursue commercial potential of blood vessel research 3
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 More than ... and about 1 in 3 seniors will die with ... ). These jaw-dropping figures have shocked many Americans into ... hopefully, help prevent these tragic age-related cognitive disorders. Jonathan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... molecules that appear in the central region of ,macromolecules ... atom ,at their center that determines their specific function. ... molecular electronics lies in their "ease of transfer ,electrons ... the work at the Nanomaterials and Nanotechnology Research Center ...
... Pharmaceuticals, Inc. (Nasdaq: ANDS ) announced today that ... Friday, September 9, 2011 at 10:55 a.m. EDT (7:55 a.m. ... Hotel in Boston.  Steve Worland, Ph.D., President and Chief Executive ... its clinical development programs, setrobuvir and ANA773. Dr. ...
... (NYSE Amex: CUR ) announced that President ... Stifel Nicolaus Annual Healthcare Conference on Wednesday, September 7 ... opportunities and advancements in neural stem cell pharmaceuticals and ... the ongoing ALS trial at Emory University. ...
Cached Biology Technology:The quantum tunneling effect leads electron transport in porphyrins 2Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 2Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 3Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference 2Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference 3
... HyPer is the first fully genetically encoded ... of intracellular hydrogen peroxide (H2O2), one of ... on the basis of yellow fluorescent protein ... coli protein OxyR (OxyR-RD), HyPer demonstrates submicromolar ...
...
Formulation: Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide....
Mouse monoclonal [0.T.81] to Lac1 ( Abpromise for all tested applications). Antigen: Recombinant TrpE fusion protein containing full length E. coli Lac1....
Biology Products: