Navigation Links
New research shows genes of pregnant women and their fetuses can increase the risk of preterm labor
Date:2/4/2010

CHICAGO, FEB. 4, 2010 New evidence that genetics play a significant role in some premature births may help explain why a woman can do everything right and still give birth too soon.

Research presented today at the 30th Annual Society for Maternal-Fetal Medicine (SMFM) meeting -- The Pregnancy Meeting -- showed that the genes of both the mother and the fetus can make them susceptible to an inflammatory response that increases the risk of preterm labor and birth.

Silent, undetected infections and inflammation are major risk factors for preterm labor and birth, says SMFM member Roberto Romero, MD, Chief of the Perinatology Research Branch at the National Institute of Child Health and Human Development. One of every three preterm births occurs to a mother who has an infection in her uterus, but has no symptoms.

Dr. Romero led a team of physicians and scientists studying a large number of genes involved in the control of labor that could help explain the complex process that triggers preterm birth. They found DNA variants in genes involved in fighting infection in the pregnant woman and the fetus. Although these variants increased the risk of preterm labor and birth, they have been preserved by evolution because they are needed to fight infection, Dr. Romero said.

Premature birth is a leading cause of infant death in the United States, and babies who survive face serious lifelong health problems. More than 543,000 babies are born too soon each year, and the nation's preterm birth rate has increased 36 percent since the early 1980s. Worldwide, about 13 million babies are born prematurely each year.

"This research gives us even more evidence as to the relationship between genetics and preterm birth and is a step toward personalized medicine," said Alan R. Fleischman, MD, medical director of the March of Dimes. "This has the potential to allow us to identify a woman who is at risk for delivering early and provide her with specialized, individualized care so that she may carry her baby to term, and help give more babies a healthy start in life."

All patients in the case-control study had at least one prior spontaneous preterm birth (less than 37 weeks of gestation). The study extracted DNA from the cord blood and maternal blood of more than 800 pregnant Hispanic women and their fetuses, and then genotyped more than 700 single nucleotide polymorphisms (SNPs) in 190 candidate genes that may predispose to preterm birth.

Fetuses that carried a SNP gene variation in IL6R, which influences inflammation, had twice the risk of preterm birth. DNA variants in maternal genes also increased the risk of preterm birth. Together these factors provide new evidence that genetic predisposition to preterm birth can depend on the DNA of both mother and fetus and how the two interact.

Today's award-winning study, "Identification of Fetal and Maternal Single Nucleotide Polymorphisms in Candidate Genes that Predispose to Spontaneous Preterm Labor with Intact Membranes," is the seventh study by SMFM members to be honored by the March of Dimes for innovative research focused on preventing premature birth. The March of Dimes is conducting a national Prematurity Campaign aimed at using research and awareness to reduce the increasing rate of premature birth.


'/>"/>

Contact: Elizabeth Lynch
elynch@marchofdimes.com
914-997-4286
March of Dimes Foundation
Source:Eurekalert

Related biology news :

1. Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
2. JDRF-funded research advances potential for regeneration as a possible cure for type 1 diabetes
3. Finland invests €1.85 million in pan-European infrastructure for biomedical research
4. NIFA awards funding for animal health and production research
5. Secrets to superb malting barleys explored by ARS researchers
6. UF researchers: Ancient crocodile relative likely food source for Titanoboa
7. UC Riversides new state-of-the-art technology to accelerate stem cell research
8. ARS researchers develop method to speed up breeding of scab-resistant barley cultivars
9. Lifestyle changes for teens critical in light of research about teens heart disease risk
10. New research rejects 80-year theory of primordial soup as the origin of life
11. Research at Marshall University may lead to new ways to transport and manipulate molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... Stock-Callers.com has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory ... technical consulting, provides a free webinar on Performing Quality Investigations: Getting ... at 12pm CT at no charge. , Incomplete investigations are still a major ...
Breaking Biology Technology: