Navigation Links
New research reveals unexpected biological pathway in glaucoma
Date:1/3/2011

(Baltimore, MD) In a study published today in the Proceedings of the National Academy of Sciences (Early Edition ahead of print), a team of researchers from the Kennedy Krieger Institute and four collaborating institutions, identified a new and unexpected biological pathway that appears to contribute to the development of glaucoma and its resulting vision loss.

Prior research has suggested that the optic nerve head, the point where the cables that carry information from the eye to the brain first exit the eye, plays a role in glaucoma. In this study, researchers report a series of findings that offer novel insights into cellular and molecular mechanisms operating at the optic nerve head in two mouse models of glaucoma. Most notably, they discovered that at a specific location within the optic nerve head, there is a unique class of cells called astrocytes that demonstrate properties that appear to make them a critical factor in the visual blinding that occurs in glaucoma.

Further, at this same site, researchers found abnormal forms of a protein called gamma synuclein that is similar to abnormal forms of alpha synuclein, a related protein known for its key role in cell loss in Parkinson's disease. The findings suggest that a biological process similar to Parkinson's disease unfolds in glaucoma at the specific anatomical location pinpointed in this study for the first time.

Finally, researchers discovered that at this anatomical location, there is a surprising process whereby astrocytes remove the debris of neurons, the cells that die in neurodegenerative disorders such as glaucoma. It is likely that this newly discovered process involving removal of the debris of one cell by a neighboring cell is important not only in glaucoma and Parkinson's disease, but also for many neurodegenerative diseases.

"These findings are very exciting because they give us several novel targets for future interventions," said Dr. Nicholas
'/>"/>

Contact: Megan Lustig
mlustig@spectrumscience.com
202-955-6222
Kennedy Krieger Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. The ecosystem engineer: Research looks at beavers role in river restoration
2. Penn Medicine researcher receives $6 million grant for cardiovascular disease study
3. Researchers discover potential solutions to New England roadside erosion
4. Scripps Research scientists identify key interaction in hepatitis C virus
5. New research contains solutions to common pear disease
6. Standardized protocols would greatly enhance clinical and research potential of BTMs
7. UK researchers contribute to sequencing strawberry genome
8. Scripps Research scientist uncovers switch controlling protein production
9. An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
10. Carnegie Mellon researchers discover mechanism for signaling receptor recycling
11. Research shows positive results with high pressure technology for certain dairy products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... MISSOULA Until recently, little has been known about ... An international team of scientists, one of whom is ... breakthrough by showing that genes controlling the development of ... for rabbit domestication., The study was published Aug. 28 ... genetic questions. It is online at http://www.sciencemag.org/ ., ...
(Date:8/29/2014)... release is available in German . ... signals between organisms is considered the oldest form of ... between conspecifics, for example, the sexual attraction between males ... responses and to coordinate reproductive behavior in males and ... University of the Algarve in Faro, Portugal, and at ...
(Date:8/28/2014)... TX Invasives is now available from the Lady Bird ... Austin for identifying harmful non-native plant, insect and other ... United States cause about $137 billion in economic and ... waterways, kill native plants and more. , "By having ... where invasive species occur, we,re more likely to catch ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Ready for mating at the right time 2Ready for mating at the right time 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... was carried out by a team of researchers led ... Medicine and Public Health at Temple University. She said, ... pre-pregnancy weight status, the odds of gaining excessively during ... who thought they weighed less than they really did. ...
... 2008) Modern humans left Africa over 60,000 years ago ... all of the human population that exist outside Africa today. ... weren,t equal partners in that exodus. By tracing variations in ... found evidence that men probably outnumbered women in that migration. ...
... at UT Southwestern Medical Center have determined that a mutation ... lungs against invading pathogens is responsible for some inherited cases ... mutation may also be associated with lung cancer, the researchers ... scientists have linked with idiopathic pulmonary fibrosis, or IPF. The ...
Cached Biology News:Who are you kidding? 2UT Southwestern researchers identify gene linked to inherited form of fatal lung disease 2UT Southwestern researchers identify gene linked to inherited form of fatal lung disease 3
(Date:8/27/2014)... , Aug. 27, 2014 Rhythm, a biopharmaceutical ... genetic deficiencies that result in metabolic disorders, announced today ... S-1 with the U.S. Securities and Exchange Commission (SEC) ... of its common stock. The number of shares to ... have not yet been determined. Citigroup and ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces ... available in its catalogue: Global ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About ... that are readily decomposed by the action ... non-degradable packaging in terms of raw materials, ...
(Date:8/27/2014)... of nature,s mysteries is how plants survive impact ... the sun,s rays, while using this energy for ... in the plant,s blades quickly dissipate the energy ... quakes. Researchers at DTU Physics have now managed ... algae and bacteria contain light-absorbing proteins which play ...
(Date:8/27/2014)... 2014 Reportlinker.com announces that a new ... Global Chelating Agents Market 2014-2018 ... Chelating Agent A chelating agent is a chemical ... ions, thereby forming a metal-ion complex. It reduces ... chemical processes, formulations, and the environment by chelating ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7DTU researchers film protein quake for the first time 2Global Chelating Agents Market 2014-2018 2Global Chelating Agents Market 2014-2018 3Global Chelating Agents Market 2014-2018 4
... Center, CHA General Hospital, Seoul 135-081, Korea, , ... (LCM) is an innovative technique which permits the rapid ... tissue sections. After LCM, RNA isolated from pure cell ... RNA (aRNA) for hybridization, and the differential gene expression ...
... Dr. Eugene Trogan, Ph.D., Mount Sinai School of Medicine ... Macrophage foam cells are integral in the ... complicated by the cellular heterogeneity of atherosclerotic plaque. This ... identified immunohistochemically, followed by real-time RT-PCR to selectively analyze ...
... , ... assay • LEADseeker • SPA Imaging Beads , ... In mammals, serotonin (5-hydroxytryptamine, 5-HT) is a regulator of neural transmission ... ,>The serotonin 5-HT 2C receptor is a subtype of the serotonin ...
Cached Biology Technology:Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 2Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 3Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 4Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 5Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 6Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 7Differential Gene Expression Analysis of Pure Cell Populations from Frozen UterineTissue Using Laser Capture Microdissection (LCM) and cDNA Microarrays 8Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 2Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 3Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 4Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 5Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 6Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 7Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 8Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 9Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 10Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions 11The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System 2The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System 3The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System 4
... measurements in an easy-to-use benchtop package. ... spectrometer (ESI-oa-TOF) concentrates the performance of ... which fits on your bench. The ... 10,000 FWHM and mass accuracy of ...
... uptake of long double stranded RNA (dsRNA) ... in a diverse group of organisms as ... interference leads to the inhibition of protein ... the target messenger RNA (mRNA). Attempts to ...
... Daltonics and Bruker BioSpins Metabolic Profiler ... studies, and analysis of complex mixtures. ... an optional Avance NMR spectrometer and ... and statistical analysis for applications like:,Assessment ...
... Tracker w/ OutputCumulates a score of movement counts, ... that it.can track up to 6 subjects at ... be triggered. Can outpt a sync pulse ... Can use animal location and timing information ...
Biology Products: