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New research provides insight into epilepsy
Date:12/20/2013

ems, the young researcher has continued to collaborate with Anne Schaefer on microRNA-128 and its function in neurons.

Experiments on mice show that you can check the amount of microRNA-128 in neurons that respond to dopamine, and thus also check how it affects a wide variety of gene expression in these neurons, which results in an altered activation of the neurons. "A large volume of microRNA-128 results in a lower neuron activity and can help to hamper the degree of activation in the musculoskeletal system.

Such a strong reaction to a change of the microRNA level is seen extremely rarely.

The reason for the intense effect of the microRNA 128 reduction in neurons must probably be found in the fact that microRNA 128 regulates a lot of the mRNAs (and, thus, many gene expressions) ", explains Morten T. Ven.

Mice are the first step - humans are the next

The new research is not yet transferable to humans, but Morten T. Ven and Jrgen Kjems are involved in a five-year EU project, where the role of microRNA in epilepsy is being examined with a view to future treatment.

In addition to microRNA 128, microRNA 134 also has an impact on epilepsy, particularly under the microscope.


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Contact: Morten Trillingsgaard Venø
mtv@mb.au.dk
45-28-72-71-07
Aarhus University
Source:Eurekalert

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