Navigation Links
New research provides insight into epilepsy
Date:12/20/2013

Jrgen Kjems and Morten Trillingsgaard Ven, Department of Molecular Biology and Genetics and the Interdisciplinary Nanoscience Centre (iNANO), contribute to an article on microRNA-128 just published in Science. In the experiments on mice, it was possible to control the amount of microRNA-128 in specific neurons that react to the signal substance dopamine. "If microRNA-128 is kept down in these neurons in neonatal mice, it results in a strong phenotype," explains Morten T. Ven. "It leads to a higher level of activity, which means the mice move more, develop epilepsy and finally die of the seizures," he clarifies.

Morten T. Ven, postdoc. at the Department of Molecular Biology and Genetics, has worked with the leader of the project Anne Schaefer during his PhD degree programme.

Here he worked on an advanced technology, where it is possible to see how microRNA binds to the mRNA.

MicroRNA works by binding to so-called Ago proteins and guiding these proteins to specific locations on the mRNA. The mRNAs are the copies of the DNA's genes, which are translated directly into protein.

The Ago proteins bind to both the microRNA and the mRNA at the same time, which either means that the mRNAs are broken down, or that the so-called translation into protein is otherwise hindered.

Morten T. Ven and Anne Schaefer worked with special mice, which had been genetically modified to produce a special type of Ago protein in the brain's neurons.

This special Ago protein, together with the RNA that was bound to it, could be purified from the brain tissue of the mice with the help of an antibody. The researchers were thus able to determine where the different microRNA in the neurons bind.

MicroRNA-128 turned out to be the microRNA that controls the greatest number of mRNAs in the brains of the mice - more specifically in the neurons!

Experiments on mice

Together with his former supervisor Jrgen Kj
'/>"/>

Contact: Morten Trillingsgaard Venø
mtv@mb.au.dk
45-28-72-71-07
Aarhus University
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern neuroscience researchers identify gene involved in response to cocaine
2. ASU researchers develop new device to help image key proteins at room temperature
3. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
4. New geology research explores intriguing questions
5. New anti-HIV drug target identified by University of Minnesota researchers
6. NSF supports collaborative cyber-enabled research to advance sustainability
7. UNIST research team opens graphene band-gap
8. Predicting antibiotic resistance among goals of UH research
9. Hack the planet? Geoengineering research, ethics, governance explored
10. MU researchers develop advanced 3-dimensional force microscope
11. Researchers explain why some wound infections become chronic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... SHELTON, Conn. , Aug. 21, 2014 ... on the growing mobile commerce market, announced today that ... purchase common stock to be issued in its proposed ... been approved for listing on The Nasdaq Capital Market, ... of the common stock and warrants, and will trade ...
(Date:8/21/2014)... A landmark study aimed at improving the food intake, ... long-term care homes is among three projects at the ... grants from the Canadian Institutes of Health Research (CIHR). ... Applied Health Sciences at Waterloo, and a Schlegel research ... two years to investigate why many Canadians living in ...
(Date:8/21/2014)... Wednesday, Oct. 18-22, 2014 , WHERE: , ... San Diego, CA 92101 , WHAT: , ... of the latest research in human genetics. Examples ... high-scoring abstracts on rare genetic variants in health ... treatment for sun sensitivity (Saturday, Oct. 18, 5:30-7:30 ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3Grants will fund landmark aging research at Waterloo 2American Society of Human Genetics 2014 Annual Meeting 2
... annual Network Science conference, an international event that brings together ... Network science is a new way of looking at ... lost cell function in medicine to preventing the failure of ... location for public facilities. "There are similarities in ...
... caused by the build-up of a protein called amyloid ... the destruction of nerve cells. Scientists had previously shown ... one another minimized brain lesions and protected nerve cells ... researchers in Germany and the USshows that an anti-inflammatory ...
... set of promising new anticancer agents could have unforeseen ... Washington University School of Medicine in St. Louis. The ... of hedgehog antagonists interfere with a biochemical process ... researchers showed that interfering with this biochemical process in ...
Cached Biology News:Certain anticancer agents could be harmful to patients with heart disease 2Certain anticancer agents could be harmful to patients with heart disease 3
(Date:8/21/2014)... August 21, 2014 His Majesty Willem-Alexander, ... , The Court of His Majesty Willem-Alexander, King of ... the Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY ... 3. , The King will take part in the ... scheduled for 11 a.m.-12:20 p.m. and tour the plant. ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... in Brazil and ... restrictions. The uptake of several newly approved agents, ... for this indication and the launch of emerging ... asthma markets. In particular, the emerging IL-5 inhibitors ...
(Date:8/21/2014)... -- China Cord Blood Corporation (NYSE: CO ) ... results for the first quarter of fiscal year 2015 ... the US.  The Company will host ... August 29, 2014 to discuss its financial performance and ... followed by a question and answer session.  Interested parties ...
(Date:8/21/2014)... August 21, 2014 Ontotext S4 ... by Ontotext . Now the same enterprise ... of structured and unstructured data is available to start-ups ... of enterprise technology. Organizations that do not have resources ... management can use S4 since there is no need ...
Breaking Biology Technology:His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4
... 11 PAREXEL International Corporation (Nasdaq: PRXL ) today ... Fiscal Year 2010 ended December 31, 2009, and for the ... Company,s updated financial guidance takes into account the projected impact ... for the amount and timing of a previously announced restructuring ...
... BOCA RATON, Fla., Jan. 11 Stem Cell Assurance, ... cell cosmetic and therapeutic procedures for individual clients, today ... its elite physician network. Stem Cell Assurance utilizes ... your body,s own regenerative cells to produce natural results, ...
... , ... Performagene™•LIVESTOCK Enables Easier, More Economical Genetic Testing to Facilitate Breed Improvements. Producers, breed ... and scalable collection device that will positively impact the industry’s ability to accelerate ... ...
Cached Biology Technology:PAREXEL Issues Updated Financial And Operational Information 2PAREXEL Issues Updated Financial And Operational Information 3PAREXEL Issues Updated Financial And Operational Information 4PAREXEL Issues Updated Financial And Operational Information 5Stem Cell Assurance Unveils Physician Network Offering Regenerative Cell Cosmetic and Reconstructive Applications 2Stem Cell Assurance Unveils Physician Network Offering Regenerative Cell Cosmetic and Reconstructive Applications 3DNA Genotek Launches New Sample Collection Product to Accelerate Livestock Genetic Testing 2DNA Genotek Launches New Sample Collection Product to Accelerate Livestock Genetic Testing 3DNA Genotek Launches New Sample Collection Product to Accelerate Livestock Genetic Testing 4
...
... essential for hunting and analyzing the ... as EST sequencing projects, microarrays, functional ... is developed for normalization of cDNA ... for directional cloning. While most normalization ...
Peptide-affinity Purified Polyclonal Antibody to ICEBERG Peptide with sequence EEDPQLASKMGLH, from C Terminus of the protein sequence according to NP_067546...
Purified anti-Fanconi anemia D2-Phosphorylated (Ser222)...
Biology Products: