Navigation Links
New research on structure of bones raises questions for treatment of osteoporosis
Date:10/16/2007

Researchers have discovered that the structure of human bones is vastly different than previously believed findings which will have implications for how some debilitating bone disorders are treated.

Researchers from the University of Cambridge, the Animal Health Trust in Newmarket, and the BAM Federal Institute of Materials Research and Testing, Berlin, have discovered that the characteristic toughness and stiffness of bone is predominantly due to the presence of specialized sugars, not proteins, as had been previous believed. Their findings could have sweeping impacts on treatments for osteoporosis and other bone disorders.

Scientists have long held the view that collagen and other proteins were the key molecules responsible for stabilizing normal bone structure. That belief has been the basis for some existing medications for bone disorders and bone replacement materials. At the same time, researchers paid little attention to the roles of sugars (carbohydrates) in the complex process of bone growth.

For this research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), the UK and Berlin teams studied mineralization in horse bones using an analysis tool called nuclear magnetic resonance (NMR). They found that sugars, particularly proteoglycans (PGs) and glycosaminoglycans (GAGs), appear to play a role which is as important as proteins in controlling bone mineralization - the process by which newly-formed bone is hardened with minerals such as calcium phosphate.

Osteoporosis is a chronic and widespread disease in which mineral formation is disturbed, leading to brittle bones, pain, and increased fractures. Osteoarthritis, a hallmark of which is joint cartilage and GAG depletion, is also accompanied by abnormal bone mineralization. Both of these diseases can be debilitating, often crippling, to older people a problem which will only intensify as our population ages. Among the young, especially sportsmen and women, bone and joint injuries prove the most intractable and are also the ones most likely to develop into afflictions (such as osteoarthritis) later in life.

Dr David Reid, from the Duer Group, Department of Chemistry,at the University of Cambridge, who played a significant part in the research, said, We believe our findings will alter some fundamental preconceptions of bone biology. On a practical level they unveil novel targets for drug discovery for bone and joint diseases, new biomarkers for diagnosis, and new strategies for developing synthetic materials that could be used in orthopaedics.

They may also strengthen the rationale for the current popularity of over-the-counter joint and bone pain remedies such as glucosamine and chondroitin, which are based on GAG sugar molecules.


'/>"/>

Contact: Genevieve Maul
genevieve.maul@admin.cam.ac.uk
44-007-774-017-464
University of Cambridge
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Research advances quest for HIV-1 vaccine
7. Research on Worms Yields Clues on Aging
8. U of M researcher examines newly emerging deadly disease
9. NYU researchers simulate molecular biological clock
10. Researchers reveal the infectious impact of salmon farms on wild salmon
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They call it the ... network, a depiction of a system of linkages and connections so complex and ... professor of computer science at Worcester Polytechnic Institute (WPI) and director of the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, ... in analytical testing are being attributed to new regulatory requirements for all new ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit ... 7th and 8th June 2018 in San Francisco, CA. The Summit brings together current ... several distinguished CEOs, board directors and government officials from around the world to address ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study ... in frozen and fresh in vitro fertilization (IVF) transfer cycles. The ... IVF success. , After comparing the results from the fresh and frozen transfer ...
Breaking Biology Technology: