Navigation Links
New research on pre-eclampsia in mice may have important implications for humans
Date:7/27/2008

WHITE PLAIN, N.Y., JULY 27, 2008 In a new March of Dimes-funded study of pre-eclampsia, a serious and potentially deadly disorder that affects about 5 percent of pregnancies, researchers have found results in mice that may have important implications for diagnosis and treatment in humans.

Yang Xia, M.D., Ph.D., and Rodney E. Kellems, Ph.D., Department of Biochemistry and Molecular Biology; and Susan M. Ramin, M.D., Department of Obstetrics, Gynecology and Reproductive Science, all at the University of Texas-Houston Medical School, and colleagues report today in the journal Nature Medicine that they induced pre-eclampsia in mice by injecting them with certain human autoantibodies that have been found in women with pre-eclampsia. The mice showed multiple features of the disorder, including dangerously high blood pressure, protein in the urine, and placental abnormalities. Then the researchers gave the mice a substance that blocks the action of the autoantibodies; this prevented the development of pre-eclampsia.

The investigators say they demonstrated an important pathway of pre-eclampsia as well as a potential new approach to diagnosis and treatment.

Pre-eclampsia may require pre-term delivery (birth before 37 completed weeks gestation) to prevent severe complications to mother and baby, because delivery is the only cure for the disorder.

Preterm birth is a serious and costly health problem and the leading cause of death in the first month of life. More than a half million babies one out of every eight are born too soon each year in the United States. Babies who survive face the risk of serious life-long health problems including learning disabilities, cerebral palsy, blindness, hearing loss, and other chronic conditions including asthma. Even infants born just a few weeks too soon have a greater risk of breathing problems, feeding difficulties, temperature instability (hypothermia), jaundice and delayed brain development.

The March of Dimes also is helping to support a large World Health Organization study to evaluate whether a new screening test is in fact a reliable predictor of the development of pre-eclampsia, as well as the feasibility of doing testing in developing nations where pre-eclampsia causes a significant number of deaths among pregnant women and babies.


'/>"/>

Contact: Michele Kling
mkling@marchofdimes.com
914-997-4613
March of Dimes Foundation
Source:Eurekalert

Related biology news :

1. New study spotlights National Institutes of Health grant outcomes for clinical research
2. CMV infections affect more than just patients with compromised immune systems, researchers find
3. A new cellular pathway linked to cancer is identified by NYU researchers
4. Limiting fructose may boost weight loss, UT Southwestern researcher reports
5. Cancer drug delivery research at Case Western Reserve University cuts time from days to hours
6. Gladstone scientists create Wikipathways to foster research collaboration
7. MSU researcher uses grant to study little-known but largely useful microbes
8. Researchers find key to saving the worlds lakes
9. MIT researchers offer glimpse of rare mutant cells
10. UC San Diego researchers could help US military thwart explosive threats
11. Researcher helping to pioneer medical therapy for Fragile X Syndrome presents latest findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 12, 2017 , ... They call it the “hairy ball.” ... depiction of a system of linkages and connections so complex and dense that ... computer science at Worcester Polytechnic Institute (WPI) and director of the university’s bioinformatics ...
(Date:10/12/2017)... Iowa (PRWEB) , ... October 12, 2017 , ... ... based in Vilnius, Lithuania, announced today that they have entered into a multiyear ... is to provide CRISPR researchers with additional tools for gene editing across all ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Market with the addition of its newest module, US Hemostats & Sealants. , ... thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used in ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... analysis platform specifically designed for life science researchers to analyze and interpret ... Rosalind Franklin, who made a major contribution to the discovery of the ...
Breaking Biology Technology: