Navigation Links
New research may aid treatment of multiple myeloma patients
Date:1/23/2013

oma cell lines by fluorescence-activated cell sorting (a specialized application of flow cytometry). These multiple myeloma populations were then characterized using RNA-seq 'deep-sequencing' gene expression analysis. Through this next-generation genomics approach, the researchers demonstrated that the CDy1-bright cells did indeed exhibit increased expression of many genes associated with stem cell activity. However, they also noted that the ABCB1 gene, which encodes the P-glycoprotein efflux transporter responsible for multi-drug resistance, was highly expressed in the CDy1-dim population. In functional studies, the investigators determined that dim CDy1 staining was due to the fact that the dye was being efficiently pumped out of the cells by the ABCB1 transporter.

Before the implementation of novel treatment regimens for multiple myeloma over the past decade, ABCB1-associated multi-drug resistance was routinely observed in patients who received conventional chemotherapy containing drugs that are ABCB1 substrates. With this in mind, Dr. Hawley and his colleagues examined new anticancer agents and discovered that high levels of ABCB1 conferred resistance to the second-in-class drug carfilzomib which is currently undergoing evaluation in multiple myeloma clinical trials. Moreover, increased resistance to carfilzomib in sensitive multiple myeloma cells following drug selection was associated with upregulation of ABCB1 cell-surface expression which correlated with increased transporter activity as measured by CDy1 efflux.

Of special note, carfilzomib (marketed under the brand name Kyprolis) recently received accelerated approval by the U.S. Food and Drug Administration for the treatment of multiple myeloma patients who have received at least 2 prior therapies and whose disease continues to worsen. Therefore, the next phase of the project, which is supported by a pilot research grant awarded in 2012 by The Dr. Cyrus and Myrtle Katzen Cancer Research
'/>"/>

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. USDA grant advancing deadly plant disease, insect research
2. £35 million to support research for vital industrial sector
3. Women must do more to reap same positive health outcomes as men, MU research suggests
4. Stem cell research helps to identify origins of schizophrenia
5. UT Dallas researchers awarded $4.3 million to create next-generation technologies
6. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
7. Men more likely to commit research misconduct than female counterparts
8. Researchers analyse rock dissolving method of geoengineering
9. Researchers show how cells DNA repair machinery can destroy viruses
10. Researchers turn one form of neuron into another in the brain
11. UGA researchers invent new material for warm-white LEDs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2015)... Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA ... NXT-ID introduces a new revolutionary method ... surrounds the use of miniature antenna modules for ...
(Date:4/2/2015)... 2015 According to preliminary estimates ... somewhat higher than 125 MSEK. This exceeds the guidance ... that revenues for Q1 2015 would be in line ... Q4 2014. The operating result for the first quarter ... interim report will as previously communicated be published on ...
(Date:4/1/2015)...   Medisafe ™, the leading global medication management ... and Android smartphones and tablets, announces ... platform to allow patients to track and correlate their ... patients will be able to visualize in real-time how ... such as glucose levels and blood pressure. ...
Breaking Biology News(10 mins):NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Revises Revenues for Q1 2015 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... Scientists at the Salk Institute for Biological Studies ... plants to adapt to various environments, but could also benefit ... March 6 in Nature , the findings show that ... world, their epigenomic makeup is as varied as the environments ...
... (CUMC) researchers have found the first evidence that selective ... hippocampus, can reduce anxiety without affecting learning. The findings ... be used to treat certain anxiety disorders, such as ... cognitive side effects. The study, conducted in mice, was ...
... MA "Use it or lose it." The saying ... to protecting against Alzheimer,s disease. Previous studies have shown ... may help delay the onset of dementia in Alzheimer,s ... Dennis Selkoe, MD, co-director of the Center for Neurologic ...
Cached Biology News:Hidden layer of genome unveils how plants may adapt to environments throughout the world 2Hidden layer of genome unveils how plants may adapt to environments throughout the world 3Portion of hippocampus found to play role in modulating anxiety 2Portion of hippocampus found to play role in modulating anxiety 3Use it or lose it 2
(Date:4/30/2015)... April 30, 2015 The following is an open ... of China Cord Blood Corp (NYSE: CO ) from ... of the independent directors of China Cord Blood Corp (" ... of $6.40 per share from Golden Meditech Holdings Co Ltd ... share would greatly benefit Golden Med and Mr. Kam, the ...
(Date:4/30/2015)... April 30, 2015  Asterias Biotherapeutics, Inc. (NYSE MKT: ... of regenerative medicine, today announced that it will release ... 7, 2015 after the close of the U.S. financial ... webcast on Thursday, May 7, 2015 at 4:30 p.m. ... and recent corporate developments. For both "listen-only" ...
(Date:4/30/2015)... FRANCE (PRWEB) April 30, 2015 ... and at http://www.lespausa.com , Phytomer’s DOUCEUR ... sensitive and reactive skin while battling the weakening ... This restorative cream is formulated with star ingredient ... via biotechnology in a complex of soothing minerals ...
(Date:4/29/2015)... 30, 2015 According to a ... by Product (Portable & Non-Portable), Component (Accelerometer, Proximity ... Chemical, Metal & Mining, & Others), & Geography ... is expected to reach $1,453.76 Million by 2020, ... market data tables and 92 figures spread through ...
Breaking Biology Technology:April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 2April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 3April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 4April 30, 2015 Open Letter to the Board of China Cord Blood Corp from Jayhawk Capital 5Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 2Phytomer introduces DOUCEUR INTEMPORELLE Restorative Shield Cream 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4
... 2011 Amgen (Nasdaq: AMGN ) and ... develop XmAb ® 5871, an Fc- engineered monoclonal antibody ... late-stage preclinical development for the treatment of autoimmune diseases. ... Amgen has the option to an exclusive worldwide license ...
... Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) today announced ... Board of Directors: Kevin L. Eastwood has ... Appleman, Ph.D. has been promoted to Senior Vice President, Research ... Senior Vice President, Drug Development and Chief Medical Officer, has ...
... France and CAMBRIDGE, Mass., Jan. 6, 2011 GENFIT ... forefront of drug discovery and development, focusing on the ... disorders, today announced its presence at two U.S. events: ... to 14th, 2011) and the Biotech Showcase (from January ...
Cached Biology Technology:Amgen and Xencor Enter Option Deal to Co-Develop Xencor's Novel Antibody for Autoimmune Diseases 2Amgen and Xencor Enter Option Deal to Co-Develop Xencor's Novel Antibody for Autoimmune Diseases 3Anadys Pharmaceuticals Augments Management Team and Board of Directors 2Anadys Pharmaceuticals Augments Management Team and Board of Directors 3Anadys Pharmaceuticals Augments Management Team and Board of Directors 4GENFIT: Strong U.S. Exposure for Its Biomarker Activity 2GENFIT: Strong U.S. Exposure for Its Biomarker Activity 3
... systems for cultivation of microorganisms and human ... bio-pharmaceutical products maximum performance and economy for ... cell fermentation 10 L 1,500 L. ... ,*Fully automated control system ,*High-quality components ...
... for foraging behavior.The Spatial Behavior line is a ... camera, frame grabber, and feature extraction software and ... up to 6 moving animals. Software automatically ... allows video replay of all or machine-selected events. ...
tracking dye in electrophoresis; free acid, C 19 H 10 BrO 5 S; MW: 669.96...
... The Rice Oligo Microarray, 22K ... of rice genes associated with biological ... abiotic stress response. Each microarray contains ... of the rice (japonica) genome focuses ...
Biology Products: