Navigation Links
New research helps explain how progesterone prevents preterm birth
Date:2/10/2011

SAN FRANCISCO, FEB. 10, 2011 -- Research presented today at the 31st Annual meeting of the Society for Maternal-Fetal Medicine (SMFM) -- The Pregnancy Meeting has found that three proteins known as XIAP, BID, and Bcl-2 are responsible in part for the success of progesterone treatments in the prevention of preterm labor. They may also play an important role in triggering normal labor.

The proteins prevent preterm birth by hindering apoptosis the normal, orderly death of cells -- in the fetal membranes. Stronger, thicker fetal membranes are less likely to rupture prematurely leading to premature delivery, according to the study led by Errol R. Norwitz, MD, PhD, Ob/Gyn-in-Chief at Tufts Medical Center and chairman of Obstetrics/Gynecology at Tufts University School of Medicine.

"Dr. Norwitz's research adds to our basic understanding of what triggers labor, how the fetal membranes rupture and the role progesterone plays," said Alan R. Fleischman, MD, medical director of the March of Dimes.

In the United States, more than half a million babies are born preterm each year. Preterm birth, before 37 weeks of pregnancy, is a serious health problem that costs the United States more than $26 billion annually. It is the leading cause of newborn death, and babies who survive often face the risk of lifetime health challenges. Even infants born just a few weeks early have higher rates of hospitalization and illness than full-term infants. The last few weeks of pregnancy are critical to a baby's health because many important organs, including the brain, are not completely developed until then.

Today's award-winning study, "Progesterone Inhibits Basal Apoptosis In Fetal Membranes By Altering Expression Of Both Pro- And Anti-Apoptotic Proteins," is the eighth study by SMFM members to be honored by the March of Dimes for innovative research focused on preventing premature birth. The research was supported in part by a March of Dimes grant. March of Dimes is conducting a national Prematurity Campaign aimed at using research and awareness to reduce the increasing rate of premature birth.


'/>"/>

Contact: Elizabeth Lynch
elynch@marchofdimes.com
914-997-4286
March of Dimes Foundation
Source:Eurekalert

Related biology news :

1. New research helps explain how progesterone preventspreterm birth
2. Single-cell marine predators unique survival mechanisms revealed: UBC research
3. Research helps drivers cut fuel use
4. Boston University School of Medicine researchers receive NIMH brain awards
5. Research team honored for innovative science to advance cancer research
6. Research proves new soybean meal sources are good fish meal alternatives
7. Springer and the French National Institute for Agricultural Research INRA team up
8. Research links 29 genome regions with common form of inflammatory bowel disease
9. Just in time for Valentines Day: UNC researchers identify a gene critical for heart function
10. Johns Hopkins researchers capture jumping genes
11. The brain knows what the nose smells, but how? Stanford researchers trace the answer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... ... and Markets has announced the addition of the "Global Military Biometrics ... forecasts the global military biometrics market to grow at a CAGR of ... prepared based on an in-depth market analysis with inputs from industry experts. ... coming years. The report also includes a discussion of the key vendors ...
(Date:12/15/2016)... 15, 2016  There is much more to innovative ... the engine. Continental will demonstrate the intelligence of today,s ... . Through the combination of the keyless entry ... biometric elements, the international technology company is opening up ... authentication. "The integration of biometric elements brings ...
(Date:12/12/2016)... 12, 2016  Researchers at Trinity College, Dublin, ... by combining the material with Silly Putty. The mixture ... detector able to sense pulse, blood pressure, respiration, ... The research team,s findings were ... here:  http://science.sciencemag.org/content/354/6317/1257 ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... ... January 21, 2017 , ... ... to bring to market a pioneering medical device for the treatment of Age-Related ... engagement contract with Emergo, a global regulatory consultancy that helps companies like ours ...
(Date:1/21/2017)... Jan. 20, 2017 Bioptix, Inc. ... announced that on January 14, 2017 the Board of ... the Company will terminate certain employees associated with the ... The Company commenced terminations on January 16, 2017 and ... The Company may pay severance benefits in certain circumstances ...
(Date:1/21/2017)... 2017   Boston Biomedical , an industry leader ... cancer stemness pathways, today presented data from two clinical ... 2017 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers ... In a Phase Ib/II study of napabucasin ... cancer stemness pathways by targeting STAT3 – colorectal cancer ...
(Date:1/20/2017)... 20, 2017 Stock-Callers.com explores the ... influenced the most recent performances of select equities. In ... RGLS ), Abeona Therapeutics Inc. (NASDAQ: ... ), and Sage Therapeutics Inc. (NASDAQ: SAGE ... View Research, global Biotech market size is expected to reach $604.40 billion by ...
Breaking Biology Technology: