Navigation Links
New research helps explain how connexin hemichannels are kept closed
Date:5/26/2009

Hemichannels are connexin channels that can dock with each other to create a gap junction across two plasma membranes. In the June 2009 issue of the Journal of General Physiology (JGP), Andrew Harris (University of Medicine and Dentistry, New Jersey) discusses new research that provides insight into how hemichannels are kept closed and lays the framework for more specific questions regarding how they open in certain conditions as part of a junctional channel (1).

As Harris explains, the gating mechanism that controls the opening and closing of hemichannelsknown as "loop gating"must remain mostly closed when unapposed and able to open when docked to another hemichannel. The relationship between the loop-gating mechanism and the structure of hemichannel docking, however, has been unclear.

Harris discusses the new research that is advancing our understanding of this relationship, including a report by Tang et al. in the June issue of JGP (2). The report, along with a recent publication from Verselis et al. (3), provides new information about the conformational changes that occur within the loop gate. In addition, the concurrent unveiling of a high-resolution structure of a connexin channel has been a long-awaited and noteworthy development (4).

According to Harris, these studies go a long way in explaining what keeps unapposed hemichannels closed and identifying new questions that provide a "welcome challenge" for researchers going forward.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... CORAL SPRINGS, Florida , November 6, 2014 ... improved secure authentication for better mobile security revolutionizing online transactions. ... NXTD ), Alibaba Holdings Ltd. (NYSE: BABA ), ... MSFT ), eBay Inc. (NASDAQ: EBAY ... (NASDAQ: NXTD and NXTDW), a biometric authentication ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
(Date:11/4/2014)... – Temple University School of Medicine announced today ... an initiative funded by the Bill & Melinda ... of Obstetrics, Gynecology and Reproductive Sciences; and Vice ... University School of Medicine will pursue an innovative ... Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2
... at the University of Wisconsin-Madison may represent a significant ... that would use this abundant element to store and ... non-carbon, non-polluting fuel for storing intermittent energy from the ... water but no carbon dioxide. Practically speaking, producing hydrogen ...
... U.S. Department of Energy,s Brookhaven National Laboratory have identified ... human adenovirus, a cause of ailments ranging from colds ... in FEBS Letters , a journal of the ... sifted through thousands of compounds to determine which might ...
... have alteration in metabolic pathways as a result of ... 2-related factor 2) works as a "master gene" that ... pollutant-detoxifying genes to protect the lungs from variety of ... However, researchers at the Johns Hopkins Bloomberg School of ...
Cached Biology News:New catalyst could cut cost of making hydrogen fuel 2Scientists identify promising antiviral compounds 2Scientists identify promising antiviral compounds 3Hijacking stress response in cancer 2
(Date:11/26/2014)... 26, 2014 The Alliance for ... survey of European physicians at the "1 ST ... Biological Therapies" at the Spanish Ministry of Health, ... EuropaBio and the Spanish Bioindustry Association (ASEBIO), included ... from Spanish oncology and rheumatology societies, representatives from ...
(Date:11/26/2014)... PMG Research, Inc. announced today the formation of ... sites that provide clinical research services to pharmaceutical companies and ... its partnerships with large physician practices and integrated health systems. ... the Southeastern United States and spans over 60 physician practices. ... will be held by: Dr. Robert Holmes, MD, of PMG ...
(Date:11/26/2014)... 2014 Silicon Valley Electronic Data Capture ... RPM Alliance , provider of clinical research and data ... latest addition to its CRO Partnership Program, Clinovo expands ... to India. , “We have found Clinovo’s ClinCapture ... EDC platform which is both user friendly and easy ...
(Date:11/26/2014)... 25, 2014 Global biostimulants market ... growing at an estimated CAGR of 12.5%. In ... food products with least ecological impacts, farmers are ... to boost crop yield more effectively & efficiently. ... can improve the return on investments. , Leading ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4
... surgeons, MONTVALE, N.J., June 3 ... information dedicated to enhancing the surgeon,s,practice, has ... engine tool:,SURGERYFINDIT.COM ( http://www.SURGERYFINDIT.COM )., As ... provide,general surgeons with a wealth of peer-reviewed, ...
... June 3 National Stem Cell,Holding, Inc. (Pink ... Steiner, MD, MBA, as its Chief Operating Officer. ... proven management and business skills.,After establishing a private ... medical and business consultant to numerous Fortune 500 ...
... ANGELES, June 3 Signalife, Inc. (Amex:,SGN) has ... Ehrlichman -- who is,already a member of the ... Operating Officer. In that capacity, Mr. Ehrlichman,s primary ... will be on,sales and marketing of the company,s ...
Cached Biology Technology:SURGERYFINDIT.COM and Convera(R) Launch Vertical Search Site for Surgeons 2National Stem Cell Holding Appoints Kenneth Steiner, MD, MBA, as Chief Operating Officer 2National Stem Cell Holding Appoints Kenneth Steiner, MD, MBA, as Chief Operating Officer 3Signalife Appoints Lee Ehrlichman President and Chief Operating Officer 2Signalife Appoints Lee Ehrlichman President and Chief Operating Officer 3
...
X-Gal, 1 g. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzymes...
Conjugation services for Antibodies, Proteins, Oligos, Peptides, Beads, bioconjugation, antibody-oligonucleotide, LNA peptide, LNA protein, LNA antibody, HRP, Alkaline phosphatase, phycoerythrin, FIT...
FGF Receptor 1 Antibody...
Biology Products: