Navigation Links
New research helps explain genetics of Parkinson's disease
Date:11/24/2008

A new study by Narendra et al. suggests that Parkin, the product of the Parkinson's disease-related gene Park2, prompts neuronal survival by clearing the cell of its damaged mitochondria.

"[This is] an exciting new discovery that links the fields of mitochondrial quality control and the genetics of Parkinson's disease (PD)," writes Heidi McBride of the University of Ottawa Heart Institute. "This work significantly increases our understanding of PD and provides a new framework for the development of therapeutic interventions."

The study, as well as McBride's commentary, will appear in the December 1, 2008 print issue of the Journal of Cell Biology (JCB). Both articles will be published online Monday, November 24 (www.jcb.org).

Loss-of-function mutations in the gene Park2, which encodes an E3 ubiquitin ligase (Parkin), are implicated in half the cases of recessive familial early-onset Parkinson's disease. Several lines of evidence suggest that Parkin loss is associated with mitochondrial dysfunction, but exactly how was unknown. To learn more about Parkin's role in cells, Narendra et al. examined the protein's subcellular location. They found that Parkin was present in the cytoplasm of most cells, but translocated to mitochondria in cells that had undergone mitochondrial damage such as membrane depolarization.

Damaged mitochondria can trigger cell death pathways; indeed, dysregulation of mitochondrial health was already thought to be a possible cause of the neuronal cell death associated with Parkinson's disease. The relocation of Parkin to damaged mitochondria, the team showed, sends these defunct organelles to autophagosomes for degradation. Parkin may thus prevent the damaged mitochondria from triggering cell death. Because neurons are not readily replicable, disposing of damaged mitochondria may be especially important in the adult brain.


'/>"/>

Contact: Rita Sullivan
rsullivan@rockefeller.edu
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology news :

1. Research consortium to sequence turkey genome
2. Scripps research team defines new painkilling chemical pathway
3. Scripps research scientists identify blood component that turns bacteria virulent
4. Household exposure to toxic chemicals lurks unrecognized, researchers find
5. Two from one: Pitt research maps out evolution of genders from hermaphroditic ancestors
6. Researcher tricks immune system in diabetic mice
7. Soybean grant gives researchers tools to unravel better bean
8. Researchers shed new light on catalyzed reactions
9. Biomedical research profits from the exploration of the deep sea
10. Researchers at IRB Barcelona produce more data on key genes in diabetes
11. Pitt researchers use fluorescence to develop method for detecting mercury in fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel visited ... to the DERMALOG stand together with the Japanese Prime Minster Shinzo Abe. ... the largest German biometrics company the two government leaders could see the ... well as DERMALOG´s multi-biometrics system.   Continue Reading ... ...
(Date:3/16/2017)... 2017 CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution against identity ... Used combined in one project, multi-biometric ... ...
Breaking Biology News(10 mins):
(Date:4/28/2017)... ... April 28, 2017 , ... KCAS ... validated a 0.2 ng/mL lower limit (LLOQ) assay for nicotine and two key ... assay, the ultra-low trace nicotine assay meets additional needs of tobacco industry that ...
(Date:4/27/2017)... ... April 27, 2017 , ... This month ... (eConsent) solution that simplifies research studies, accelerates study startup, and improves participant engagement. ... Consent™ is the first and only IRB-integrated eConsent solution . , “Our ...
(Date:4/27/2017)... ... April 27, 2017 , ... Volunteers supported by SPIE, ... and industry professionals in visiting U.S. Congressional offices in Washington, D.C., yesterday to ... photonics industry. , This year, National Photonics Initiative (NPI) Congressional Visits ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... ... has teamed up with NASA to showcase the future of deep space exploration ... System (SLS) rocket and Orion spacecraft and includes a guest appearance by former ...
Breaking Biology Technology: