Navigation Links
New research backs theory that genetic 'switches' play big role in human evolution
Date:6/19/2013

doing so, switch genes on and off.

Among the findings, the study reports that when compared with protein coding genes, binding site DNA shows close to three times as many "weakly deleterious mutations," that is, mutations that may weaken or make an individual more susceptible to disease, but are generally not severe. Weakly deleterious mutations exist in low frequencies in a population and are eventually weeded out over time. These mutations are responsible for many inherited human diseases.

While genes generally tend to resist change, a mutation occasionally leads to a favorable trait and increases across a population; this is called positive selection. By contrast, "transcription factor binding sites show considerable amounts of positive selection," said Arbiza, with evidence for adaptation in binding sites that regulate genes controlling blood cells, brain function and immunity, among others.

"The overall picture shows more evolutionary flexibility in the binding sites than in protein coding genes," said Siepel. "This has important implications for how we think about human evolution and disease."

This is one of the first studies to combine recent data that identifies transcription factor binding sites, data on human genetic variation and genome comparisons between humans and apes. A new computational method called INSIGHT (Inference of Natural Selection from Interspersed Genomically coHerent elemenTs), designed by Ilan Gronau, a postdoctoral researcher in Siepel's lab and a co-author of the study, allowed the scientists to integrate these diverse data types and find evidence of natural selection in the regulatory DNA.

"Transcription factor binding sites are probably the regulatory elements we know the most about," said Arbiza. "If you want to understand evolution of gene expression regulation, that's a good starting point."

INSIGHT may now be used by other researchers for analyzing other short regulatory DNA
'/>"/>

Contact: John Carberry
johncarberry@cornell.edu
607-255-5353
Cornell University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. U-M researcher and colleagues predict possible record-setting Gulf of Mexico dead zone
2. Novel enzyme from tiny gribble could prove a boon for biofuels research
3. UT Arlington research to benefit quality, flow in 150-mile Integrated Pipeline
4. Wayne State welcomes undergraduates from around the US for physics research experience
5. Saint Louis University researchers discover a way to detect new viruses
6. NIH fellowship helps researcher fight malaria, understand mosquito immunity
7. OU researchers collaborate on $20 million NSF EPSCoR grant
8. Researchers unearth bioenergy potential in leaf-cutter ant communities
9. Drug development venture links translational research, business to launch new therapeutics
10. Albert Einstein College of Medicine hosts conference on Jewish genetic research
11. MIT and Wilson Center receive NSF grant to develop synthetic biology research agenda
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/20/2015)... 2015 Research and Markets ( ... "India Sensors Market Forecast and Opportunities 2020" ... sensor market is projected to grow at a ... electronics, automotive, industrial and healthcare sectors are the ... In addition, adoption of MEMS technology in sensors ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... pharmaceutical ads in American medical journals and found that ... the majority of references to published material was available, ... upon request; and the majority of original research cited ... affiliated with the product's manufacturer. , In one of ...
... that termites use vibrations to choose the wood they ... infestations in homes and also may provide insights into ... ignore most noise but have some signals that trigger ... CSIRO entomologist Theo Evans says laboratory experiments have found ...
... readily available. However, a,similar and equally dangerous addiction, ... it be? Researchers from the University of,California in ... block,alcohol addiction in rodents. We can only hope ... a close future; it would help fix a,problem ...
Cached Biology News:UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims 2UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims 3Termites feed through good vibrations 2Controversial drug shown to act on brain protein to cut alcohol use 2Controversial drug shown to act on brain protein to cut alcohol use 3
(Date:4/17/2015)... April 17, 2015 CIO Review ( ... its 20 Most Promising Pharma and Life Science Technology ... MediSpend global compliance software platform for life sciences companies. ... by a panel of experts and members of CIO ... “MMIS’s MediSpend Platform has been on our radar for ...
(Date:4/17/2015)... TX (PRWEB) April 17, 2015 ... and proteomics technologies, announced today that it is ... system, an innovative multiplex PCR based targeted sequencing ... resolution sequence analysis, that enables accurate detection of ... Relay-PCR™ and Omega-Primer™ technologies. The company will collaborate ...
(Date:4/16/2015)... Francisco, CA (PRWEB) April 16, 2015 ... scheduled to report first quarter results on Thursday, April ... announcement, Cytokinetics’ senior management will host a conference call ... financial results and the company’s outlook for the future. ... can be accessed from the homepage and in the ...
(Date:4/16/2015)... Streetsboro, Ohio (PRWEB) April 16, 2015 ... Safety Index, overexertion involving an outside source was ... injuries. This includes injuries related to lifting, pushing, ... $15.1 billion in direct costs. The David Round ... Round is committed to working hard to develop ...
Breaking Biology Technology:MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... was announced as the recipient of a $750,000 investment by the ... ... (Business Wire EON) December 9, 2008 -- Invest Michigan!, a ... as one of only two companies to receive capital in its ...
... 9 BioMarin Pharmaceutical,Inc. (Nasdaq: ... Merck Serono, a division,of Merck KGaA, Darmstadt, ... dihydrochloride) for the treatment of,hyperphenylalaninemia (HPA) in ... European Commission. Merck Serono estimates that ...
... - a privately held developer of novel biomedical-polymers for ... it has secured a $5mm financing round. Participating in ... and BDC Capital. In connection with the financing, Lily ... Directors and Thomas P. Reeves has been appointed the ...
Cached Biology Technology: EcoSphere(R) Biolatex(TM) Secures Funding from Granholm and Invest Michigan! 2Kuvan Receives Marketing Approval in the European Union 2Kuvan Receives Marketing Approval in the European Union 3Kuvan Receives Marketing Approval in the European Union 4Interface Biologics secures $5mm financing and appoints Thomas P. Reeves President and Chief Executive Officer 2
PI/RNase Staining Buffer Solution , 100 ml Consult technical datasheet for details....
Oct 2 Immunogen: Full length human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
... isomers are predominantly used for labeling proteins, ... labeling peptides and nucleotides because they give ... often required in the conjugation processes. 5-TAMRA ... labeling peptides and proteins. 6-TAMRA is predominately ...
Biology Products: