Navigation Links
New relief for gynecological disorders
Date:4/3/2013

on both pro-angiogenic factors such as VEGF and anti-angiogenic factors including PEDF. The effect of PEDF in decreasing abnormal angiogenesis has been extensively investigated in the eye and in tumors. Prof. Shalgi and Dr. Chuderland hypothesized that the same protein could play a role in diseases of the female reproductive system related to blood vessels growth.

In both OHSS and endometriosis, rampant VEGF levels allow for the abnormal vascularization that characterises both diseases. To counteract this effect and restore a healthy angiogenic balance in the reproductive system, the researchers turned to PEDF as a replacement therapy agent. In the lab, Prof. Shalgi and Dr. Chuderland developed mouse models of both endometriosis and OHSS. After preparing the PEDF protein, they injected the mice with it.

The researchers noted a "perfect reversal" of all symptoms, including reduced abdominal swelling in OHSS-induced mice and eradicated lesions in endometriosis. When evaluating whether this protein might affect fertility, they confirmed that PEDF had no negative impact on ovulation or pregnancy rate. In fact, it increased the number of ovulated eggs in the endometriosis model, suggesting improved fertility.

Easing the pain

The next step is to commercialize the protein for therapeutic use, say the researchers, who were the first to prove that this anti-angiogenic protein is active in the reproductive system. This discovery has been patent protected and is currently undergoing commercialization by Ramot, the technology transfer company of TAU.

There are currently no treatment options for women suffering from these diseases, explains Dr. Chunderland, who believes that endometriosis, in particular, is under-diagnosed and usually dismissed as severe menstrual pain. This new treatment could bring long-awaited relief from painful and seemingly uncontrollable symptoms, including severe abdominal pain and infertility issu
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Interventional radiologists see significant symptom relief in MS patients
2. Pain relief with PAP injections may last 100 times longer than a traditional acupuncture treatment
3. Pioneering self-contained smart village offers world model for rural poverty relief
4. Backpainrelief.net Tackles Sports Injuries with Infographic
5. When the going gets tough, the tough get... more relief from a placebo?
6. A birds song may teach us about human speech disorders
7. Record-breaking grant: New research project to investigate the causes of mental disorders
8. Gene mutation identified as contributor to autism spectrum disorders
9. New genes contributing to autism and related neurodevelopmental disorders uncovered
10. March of Dimes awards $250,000 prize to 2 scientists who pioneered advances in skin disorders
11. Mice with big brains provide insight into brain regeneration and developmental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... international team of researchers, including scientists from the Max ... a reported a major step in understanding photosynthesis, the ... maintains the oxygen in its atmosphere and which is ... earth. , The researchers report the first direct ... namely the step in which a specific protein complex, ...
(Date:7/11/2014)... the marginal division of the striatum is also ... impact degree of substance P in the striatal ... Yu and his team, College of Biophotonics, South ... that substance P receptor, neurokinin 1 was highly ... of normal rats. Unilateral or bilateral injection of ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... Women who are satisfied with everyday life and ... alcohol, reveals a thesis from the University of Gothenburg, ... thesis, has looked at how everyday life affects alcohol ... in Gothenburg (WAG) population study which has been ongoing ...
... immune system can affect healthy people,s personality traits as ... suicidal behaviour, reveals a thesis from the University of ... system and is responsible for defending humans against infection ... is therefore vital for our survival. Research has demonstrated ...
... The more allergies one has, the lower the risk ... published in Cancer Epidemiology, Biomarkers & Prevention , ... Researchers from the University of Illinois at Chicago, ... use for 419 patents with glioma and 612 cancer-free ...
Cached Biology News:Women involved in leisure activities drink less alcohol 2Genes of the immune system are associated with increased risk of mental illness 2Allergies lower risk of low- and high-grade glioma 2
(Date:7/10/2014)... 10, 2014 Deep Knowledge Ventures ... Forum on ‘Commercialising Longevity Research’ and welcomed a ... the London Bioscience Innovation Center for the event, ... Aging Analytics Ltd. The meeting highlighted the need ... research for age-related disease, as well as the ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Unraveling ... closer together. The Archer Family purchased a ... within DNA, but ended up with a lifetime of ... contained within the family members’ DNA genuinely brought the ... decided to search deeper into genetic history and prior ...
(Date:7/10/2014)... Montreal, QC (PRWEB) July 10, 2014 ... comfort and convenience. This rejuvenating device now comes with a ... that develops over time. , The new cup is thinner ... This design works to target rough, thin and uneven surfaces ... original firm cup for a stimulating treatment on areas such ...
(Date:7/10/2014)... 10, 2014 On July 9 ... , presented Russia,s first national ... The Company is developing a unique project called ... develops a number of innovative drugs based on monoclonal ... ceremony took place at the International Exhibition "Innoprom 2014" ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that it ... enrolment in its U.S. Phase II trial to,evaluate ... sarcomas that have metastasized to the lung., ... full enrolment of 52,patients, Oncolytics had to demonstrate ...
... the gecko,s uncanny ability to climb sheer walls, researchers at ... is the first to master the easy attach and easy ... useful for a range of products, from climbing equipment to ... material is crafted from millions of tiny, hard, plastic fibers ...
... blueprint of all life, giving instruction and function to ... beings. Now Northwestern University researchers report they have used ... build a three-dimensional structure out of gold, a lifeless ... the researchers built two common but very different crystalline ...
Cached Biology Technology:Oncolytics Biotech Inc. Proceeds to Full Enrolment in U.S. Phase II Sarcoma Clinical Trial 2Oncolytics Biotech Inc. Proceeds to Full Enrolment in U.S. Phase II Sarcoma Clinical Trial 3The pitter patter of little feet ... climbing straight up a wall 2DNA is blueprint, contractor and construction worker for new structures 2DNA is blueprint, contractor and construction worker for new structures 3
Hepatocyte Differentiation Environment...
...
High voltage electrophoresis power supply...
... Major Science Major Science MS 300V (Cat. ... supply designed to meet most electrophoresis needs ... unit. Major Science MS 300V power supply ... to instruments used in electrophoresis. 4 pairs ...
Biology Products: