Navigation Links
New regulatory mechanism discovered for cell identify and behavior in forming organs
Date:10/31/2008

ructures then spread into surrounding organs and tissues.

In cancer development, the research team is suggesting a loss of Sfrp function may unleash Wnt to trigger elevated B-catenin expression, allowing its stimulation of cell-to-cell adhesion to proliferate quickly. Rapid cell proliferation and adhesion are common in cancerous and pre-cancerous conditions. It could also let Wnt send improper signals that cause a loss of structural integrity in epithelial cells, allowing cancer to spread, or metastasize.

"We talked about this mechanism in the context of cancer because the control of cell specificity, and of movement and behavior, also occurs in cancer," Dr. Zorn said. "Cells will start to proliferate out of control and then, when a cancer starts to go metastatic, they will also start to change behavior. They become motile, moving spontaneously and actively, and they become invasive."

The early stage nature of the study means it would be premature to suggest the Wnt11-Sfrp5 mechanism might become the basis of diagnostic or therapeutic strategies for patients, Dr. Zorn said. The next step is to use these results as a basis for future studies, probably involving mice, to verify the mechanism's applicability to mammalian embryo development and see how it affects disease, he said.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Use of nanomaterials in food packaging poses regulatory challenges
2. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
3. Corn researchers discover novel gene shut-off mechanisms
4. New cell division mechanism discovered
5. Scientists unveil mechanism for up and down in plants
6. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
7. Rong Li Lab probes mechanism of asymmetry in meiotic cell division
8. Conaway Lab identifies novel mechanism for regulation of gene expression
9. New mechanism for cardiac arrhythmia discovered
10. Novel anti-cancer mechanism found in long-lived rodents
11. Oxidative stress: Mechanism of cell death clarified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 2015  It is gratifying to see that the ... genomic science as a means to better understand human ... I was honored to participate in today,s White House ... Since the 1980s my teams have ... first sequenced genome of a free living organism, the ...
(Date:1/22/2015)... Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), ... crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz ... production capacity to meet customer demand. ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by ...
(Date:1/22/2015)... and POINT ROBERTS, Washington , January 20, ... leading sectors including technology and tech stocks, releases video from ... master pickpocket and security consultant Apollo Robbins . ... talks about the Wocket™ biometric smart wallet, a product of ...
Breaking Biology News(10 mins):J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... Israel The Israeli Chairmanship of EUREKA, the largest pan-European ... new data from a report conducted by Kalman Gayer ... Ltd., to mark the completion of Israel,s Chairmanship year ... proven impact of EUREKA on companies participating in EUREKA ...
... This release is available in German . ... congenital deaf-blindness in humans and affects 1 in 6,000 of ... both clinically and genetically heterogeneous. In the most severe cases, ... degeneration of the retina in puberty, ultimately resulting in complete ...
... are the most abundant parasites on Earth. Well known viruses, ... such as the tobacco mosaic virus infect plant hosts. ... bacteria known as bacteriophages, or phages. In part, this is ... have been cut off from their usual biological surroundings in ...
Cached Biology News:Is governmental investment in industrial R&D paying off? 2Is governmental investment in industrial R&D paying off? 3Treatment approach to human Usher syndrome: Small molecules ignore stop signals 2Treatment approach to human Usher syndrome: Small molecules ignore stop signals 3When viruses infect bacteria 2
(Date:2/27/2015)... GERMANTOWN, Md. and SUMMERLAND, British ... Corporation (NYSE: XON ), a leader ... an agreement to acquire  Okanagan Specialty Fruits (OSF), ... apple , the world,s first non-browning apple. Through ... trees yielding fruit that is more appetizing and convenient ...
(Date:2/27/2015)... A paper published today, " Financing ... in Science Translational Medicine, demonstrates the ... the risk associated with investing in the treatment ... of funding for developing so-called "orphan" drugs. ... between scientists at the National Center for Advancing ...
(Date:2/27/2015)... February 27, 2015 Immunovaccine Inc. ... immunotherapy company, today announced that the U.S. Food ... Fast Track designation and Phase I clinical trials ... with the mutual co-development agreement signed with Gilead ... Track designation for the DPX-Survivac. , “We have ...
(Date:2/27/2015)... -- Bionomics Limited (ASX:BNO, ADR:BMICY) is to present important ... patients with metastatic renal cancer at the ASCO Genitourinary ... The data will be presented by Dr. Sumanta ... Center in California in his ... Ferritin and IL-8 as two baseline biomarkers that correlate ...
Breaking Biology Technology:Intrexon to Acquire Okanagan Specialty Fruits 2Intrexon to Acquire Okanagan Specialty Fruits 3Intrexon to Acquire Okanagan Specialty Fruits 4New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 2New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 3New Financing Technique May Hold Key to Unlocking Funding for Rare Diseases 4Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 2Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 2New BNC105 Biomarker Data to be Presented at US Cancer Conference 3New BNC105 Biomarker Data to be Presented at US Cancer Conference 4New BNC105 Biomarker Data to be Presented at US Cancer Conference 5
... Inc. (NYSE Amex: PTN ) today announced ... a strategic reassessment of its research and development activities ... resources and efforts on clinical trials of bremelanotide for ... severe asthma. In implementing this plan, Palatin is reducing ...
... DIEGO, Sept. 24 Cylene Pharmaceuticals, Inc. announced ... trial of their first-in-class, oral CK2 inhibitor CX-4945 ... the simultaneous closing of a $12 million financing ... HBM BioVentures (Cayman) Ltd., Novartis BioVenture Fund, BioVentures ...
... PHILADELPHIA, BOONTON, N.J. and BRUSSELS, Sept. 24 ... Bulletin Board: UGNE ) today reported ... effects in combination with other drugs in reducing ... are being presented at the 2010 Osteoarthritis Research ...
Cached Biology Technology:Palatin Announces Strategic Realignment of Operations 2Palatin Announces Strategic Realignment of Operations 3Palatin Announces Strategic Realignment of Operations 4Palatin Announces Strategic Realignment of Operations 5Cylene Initiates Phase I Trial in Multiple Myeloma With CX-4945 Inhibitor of CK2 and Closes Accompanying Financing 2Cylene Initiates Phase I Trial in Multiple Myeloma With CX-4945 Inhibitor of CK2 and Closes Accompanying Financing 3Tarsa Therapeutics and Unigene Present Preclinical Data Suggesting Calcitonin May Have Utility in Combination Therapy for the Treatment of Osteoarthritis 2Tarsa Therapeutics and Unigene Present Preclinical Data Suggesting Calcitonin May Have Utility in Combination Therapy for the Treatment of Osteoarthritis 3Tarsa Therapeutics and Unigene Present Preclinical Data Suggesting Calcitonin May Have Utility in Combination Therapy for the Treatment of Osteoarthritis 4Tarsa Therapeutics and Unigene Present Preclinical Data Suggesting Calcitonin May Have Utility in Combination Therapy for the Treatment of Osteoarthritis 5
... to MLF1 Interacting Protein/PBIP1 (phospho T78) ... applications). Antigen: ... acids 73-83 of Human MLF1 Interacting ... ID: 359815 ...
... Ultrapure C 25 H 27 N 2 ... PRODUCT SPECIFICATIONS Form: Dark burgundy metallic powder Identity: ... 2 O, 1 cm): greater than or equal ... Drying: less than or equal to 10.0% lambda ...
... selects single cells, or clusters, with rapid, ... all, a single cell can be targeted, ... collected into the pipette, and automatically transferred ... plate. Quixells unique aspiration and expulsion system ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Viruses microRNA Microarray contains ...
Biology Products: