Navigation Links
New pump created for microneedle drug-delivery patch
Date:9/1/2010

WEST LAFAYETTE, Ind. - Purdue University researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

The current "transdermal" patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, said Babak Ziaie, a professor of electrical and computer engineering and biomedical engineering.

"There are only a handful of drugs that currently can be administered with patches," he said. "Most new drugs are large molecules that won't go through the skin. And a lot of drugs, such as those for treating cancer and autoimmune disorders, you can't take orally because they aren't absorbed into the blood system through the digestive tract."

Patches that used arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, he said.

"It's like a bandage - you would use it and discard," Ziaie said.

The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns, or roughly one-fourth as wide as a human hair. However, pumps on the market are too complex for patches, he said.

"We have developed a simple pump that's activated by touch from the heat of your finger and requires no battery," Ziaie said.

The pump contains a liquid that boils at body temperature so that the heat from a finger's touch causes it to rapidly turn to a vapor, exerting enough pressure to force drugs through the microneedles.

"It takes 20 to 30 seconds," Ziaie said.

The liquid is contained in a pouch separated from the drug by a thin membrane made of a rubberlike polymer, called polydimethylsiloxane, which is used as diaphragms in pumps.

Research findings are detailed in a paper being presented during the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences on Oct. 3-7 at University of Groningen in The Netherlands. The paper was written by electrical and computer engineering doctoral students Charilaos Mousoulis and Manuel Ochoa and Ziaie.

Researchers have filed an application for a provisional patent on the device.

Ziaie has tested prototypes with liquids called fluorocarbons, which are used as refrigerants and also in semiconductor manufacturing.

"You need a relatively large force, a few pounds per square inch, to push medications through the microneedles and into the skin," Ziaie said. "It's very difficult to find a miniature pump that can provide that much force."

Findings indicate prototypes using the fluorocarbon HFE-7000 exerted 4.87 psi and another fluorocarbon, FC-3284, exerted 2.24 psi.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Related biology news :

1. A lab rat -- created in the lab
2. Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers
3. Alzheimers rat created for human research
4. New period of brain plasticity created with transplanted embryonic cells
5. MSU scientists unlock key enzyme using newly created cool method
6. 3-D kidney atlas created for researchers and physicians
7. Most extensive genetic resource for reef-building coral created
8. Microneedle, quantum dot study opens door to new clinical cancer tools
9. Ocean stirring and plankton patchiness
10. Even small patches of urban woods are valuable for migrating birds
11. Ancient artifacts reveals as northern ice patches melt
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New pump created for microneedle drug-delivery patch
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... , April 15, 2016  A new partnership ... more accurate underwriting decisions in a fraction of ... competitively priced and high-value life insurance policies to ... With Force Diagnostics, rapid testing (A1C, ... data readings (blood pressure, weight, pulse, BMI, and ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report ... detail how a patient who developed lymphedema after being treated for breast cancer benefitted ... change the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... quality, regulatory and technical consulting, provides a free webinar on Performing ... July 13, 2016 at 12pm CT at no charge. , Incomplete investigations are ...
(Date:6/23/2016)... ReportsnReports.com adds 2016 global ... pharmaceuticals section with historic and forecast data along ... Complete report on the Cell Culture ... companies and supported with 261 tables and figures ... The Global Cell Culture Media Industry ...
Breaking Biology Technology: