Navigation Links
New pump created for microneedle drug-delivery patch
Date:9/1/2010

WEST LAFAYETTE, Ind. - Purdue University researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

The current "transdermal" patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, said Babak Ziaie, a professor of electrical and computer engineering and biomedical engineering.

"There are only a handful of drugs that currently can be administered with patches," he said. "Most new drugs are large molecules that won't go through the skin. And a lot of drugs, such as those for treating cancer and autoimmune disorders, you can't take orally because they aren't absorbed into the blood system through the digestive tract."

Patches that used arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, he said.

"It's like a bandage - you would use it and discard," Ziaie said.

The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns, or roughly one-fourth as wide as a human hair. However, pumps on the market are too complex for patches, he said.

"We have developed a simple pump that's activated by touch from the heat of your finger and requires no battery," Ziaie said.

The pump contains a liquid that boils at body temperature so that the heat from a finger's touch causes it to rapidly turn to a vapor, exerting enough pressure to force drugs through the microneedles.

"It takes 20 to 30 seconds," Ziaie said.

The liquid is contained in a pouch separated from the drug by a thin membrane made of a rubberlike polymer, called polydimethylsiloxane, which is used as diaphragms in pumps.

Research findings are detailed in a paper being presented during the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences on Oct. 3-7 at University of Groningen in The Netherlands. The paper was written by electrical and computer engineering doctoral students Charilaos Mousoulis and Manuel Ochoa and Ziaie.

Researchers have filed an application for a provisional patent on the device.

Ziaie has tested prototypes with liquids called fluorocarbons, which are used as refrigerants and also in semiconductor manufacturing.

"You need a relatively large force, a few pounds per square inch, to push medications through the microneedles and into the skin," Ziaie said. "It's very difficult to find a miniature pump that can provide that much force."

Findings indicate prototypes using the fluorocarbon HFE-7000 exerted 4.87 psi and another fluorocarbon, FC-3284, exerted 2.24 psi.


'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Related biology news :

1. A lab rat -- created in the lab
2. Smart orthopedic implants and self-fitting tissue scaffolding created by UMMS researchers
3. Alzheimers rat created for human research
4. New period of brain plasticity created with transplanted embryonic cells
5. MSU scientists unlock key enzyme using newly created cool method
6. 3-D kidney atlas created for researchers and physicians
7. Most extensive genetic resource for reef-building coral created
8. Microneedle, quantum dot study opens door to new clinical cancer tools
9. Ocean stirring and plankton patchiness
10. Even small patches of urban woods are valuable for migrating birds
11. Ancient artifacts reveals as northern ice patches melt
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New pump created for microneedle drug-delivery patch
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
(Date:3/14/2016)... Florida , March 14, 2016 ... the growing mobile commerce market, announces the airing of a ... channels starting the week of March 21 st .  The ... CNBC, including its popular Squawk on the Street show. ... focused on the growing mobile commerce market, announces the airing ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ReportsnReports.com adds 2016 global ... on US, EU, China ... healthcare business intelligence collection of its growing online ... on the Flow Cytometry market spread across 153 ... tables and figures is now available at ...
(Date:4/26/2016)... ... April 26, 2016 , ... ... Ardy Arianpour has joined the company as Chief Business Officer. Arianpour, a genomics ... genomic technologies to market, was most recently Chief Commercial Officer of Pathway Genomics. ...
(Date:4/26/2016)... ... April 26, 2016 , ... Heidelberg Instruments, ... latest technology innovation for its Volume Pattern Generator (VPG) line of lithography systems. ... advanced photomasks as well as a solution for mid volume direct write lithography ...
(Date:4/26/2016)... ... April 26, 2016 , ... This unique "Fertility Happy Hour" event ... attendees an opportunity to get the lowdown on female fertility and the reproductive technologies ... Dr. Jesse Hade, of Boston IVF - The Arizona Center, will give a short ...
Breaking Biology Technology: