Navigation Links
New protein structure could help treat Alzheimer's, related diseases
Date:7/28/2014

esent usually isn't done until after death, in an autopsy.

As a result, many dementias are broadly diagnosed as Alzheimer's disease without definitive proof, and other diseases can go undiagnosed and untreated.

The molecular structure of an amyloid protein can be only slightly different from a normal protein and can transform to a toxic state fairly easily, which is why amyloid diseases are so prevalent. The researchers built a protein structure, called "alpha sheet," that complements the toxic structure of amyloid proteins that they discovered in computer simulations. The alpha sheet effectively attacks the toxic middle state the protein goes through as it transitions from normal to abnormal.

The structures could be tailored even further to bind specifically with the proteins in certain diseases, which could be useful for specific therapies. The researchers hope their designed compounds could be used as diagnostics for amyloid diseases and as drugs to treat the diseases or at least slow progression.

"For example, patients could have a broad first-pass test done to see if they have an amyloid disease and then drill down further to determine which proteins are present to identify the specific disease," Daggett said.

The research team includes Gene Hopping, Jackson Kellock and James Bryers of UW bioengineering; Gabriele Varani and Ravi Pratap Barnwal of UW chemistry; Peter Law, a former UW graduate student; and Byron Caughey of the National Institutes of Health's Rocky Mountain Laboratories. Working with the UW's Center for Commercialization, they have a patent on one compound and have submitted an application to patent the entire class of related compounds.

This research began a decade ago in Daggett's lab when a former graduate student, Roger Armen, first discovered this new secondary structure through computer simulations. Daggett's team was able to prove its validity in recent years by designing stable co
'/>"/>

Contact: Michelle Ma
mcma@uw.edu
206-543-2580
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. A protein couple controls flow of information into the brains memory center
2. Protein evolution follows a modular principle
3. High matrix metalloproteinase-9 expression induces microangiogenesis after cerebral infarction
4. Scientists map one of most important proteins in life -- and cancer
5. Measuring the number of protein molecules inside cells
6. National Xenopus resource at the MBL innovates new way to study proteins
7. Cell membrane proteins give up their secrets
8. Proteins hands enable bacteria to establish infection, research finds
9. SLU scientists hit delete: Removing regions of shape-shifting protein explains how blood clots
10. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
11. Research reveals how key controller protein is switched on
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New protein structure could help treat Alzheimer's, related diseases
(Date:12/22/2014)...  NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announces it ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID ... some of his famous theft techniques to visiting media ...
(Date:12/22/2014)...  The 2014 Holiday Season may be the ... Market Intelligence reports that the long anticipated floodgates ... forecasts that intensifying demand for smart phones, tablets, ... drive a global market of 2.5 billion users ... According to Maxine Most ...
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... North America Perimeter Security Systems Market" report to ... The North American perimeter security market is ... 2014 to 2019. Although the U.S. market holds a ... is expected to grow at a higher CAGR ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... WI, SEPTEMBER 7, 2010 The American Society of ... Soil Science Society of America (SSSA) will present the ... on Oct. 31-Nov. 3 in Long Beach, CA, ... , , The Hank Beachell Future Leader ...
... research on how genes affect responses to medicines, the National ... to expand a key resource, the Pharmacogenomics Knowledge Base (PharmGKB), ... is to use information about a patient,s genetic make-up to ... grown, so has PharmGKB. Begun in 2000 to catalog links ...
... St. Louis, MO Current research provides a novel ... LaBranche et al, "Characterization of the KRN cell transfer model ... the K/BxN mouse," appears in the September 2010 issue of ... of the population is affected by rheumatoid arthritis, and women ...
Cached Biology News:ASA, CSSA and SSSA present scholarships and fellowships 2ASA, CSSA and SSSA present scholarships and fellowships 3ASA, CSSA and SSSA present scholarships and fellowships 4ASA, CSSA and SSSA present scholarships and fellowships 5ASA, CSSA and SSSA present scholarships and fellowships 6ASA, CSSA and SSSA present scholarships and fellowships 7ASA, CSSA and SSSA present scholarships and fellowships 8ASA, CSSA and SSSA present scholarships and fellowships 9NIH expands key pharmacogenomics resource 2Casing the joint 2
(Date:12/24/2014)... China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... Shandong Taibang Biological Products Co. Ltd., has received ... Food and Drug Administration (the "CFDA") for its ... in the Company,s public filings, the CFDA inspected ...
(Date:12/24/2014)... , Dec. 23, 2014  NeuroLifeSciences announced today ... in children with attention deficit/hyperactivity disorder published in ... The paper, titled "Pilot Phase 2 ... ( Konofal et al, Drug Des Devel ... shows that mazindol might be an effective, well-tolerated, ...
(Date:12/22/2014)... 2014 GenomeDx Biosciences today announced that a ... a genomic test for prostate cancer, was able to ... by radical prostatectomy without adjuvant therapy. Although rapid metastasis ... using tumor genomics to identify these men who have ... important advance. The study has been published online ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Bioject ... developer and manufacturer of needle-free injection technology, today ... with Immunomic Therapeutics, Inc. (“ITI”) for ITI to ... with its LAMP™ vaccine platform. , In ... exclusive Worldwide license to the Biojector®-2000 that triggers ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... , RICHMOND, Calif., Sept. 16 Sangamo BioSciences, ... Sangamo,s president and CEO, will provide an update on the progress ... company,s business strategy at 1:30 pm ET on Wednesday, September 23, ... held in New York City. , , The ...
... ANTONY, France, September 16 Stallergenes S.A.,has ... trial,(VO59.08) conducted in allergic rhinitis caused by birch pollen and,concerning ... of this pollen, rBet v 1. , ... recombinant allergen as an active,substance. To Stallergenes, knowledge, the use ...
... Sept. 16 /PRNewswire-Asia/ -- Fortis Healthcare, one of ... broaden inclusion,criteria for its upcoming diabetic foot clinical ... peripheral blood to treat critical limb ischemia,(diabetic foot). ... management, risk reduction and lengthy rehabilitation. The current,treatments ...
Cached Biology Technology:Sangamo BioSciences Announces Presentation at the UBS Global Life Sciences Conference 2STALLERGENES: Immunotherapy Tablet Containing Recombinant Allergen (rBet v 1) of Birch Pollen: Positive Results for a Phase IIb/III Trial 2STALLERGENES: Immunotherapy Tablet Containing Recombinant Allergen (rBet v 1) of Birch Pollen: Positive Results for a Phase IIb/III Trial 3STALLERGENES: Immunotherapy Tablet Containing Recombinant Allergen (rBet v 1) of Birch Pollen: Positive Results for a Phase IIb/III Trial 4Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 2Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 3Indian Stem Cell Trial to Broaden Diabetic Foot Inclusion Criteria 4
... Butcher (1998). • The major histocompatibility complex ... the immunology area. There is great interest ... in their function as antigen-presenting molecules. Many ... prospect of tackling biochemical and genetic techniques ...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
... 71-18 mutS and ES1301 mutS are mismatch ... of these strains prevents repair of the ... high mutation efficiencies and making them helpful ... Altered Sites II Mutagenesis Systems. Both ES1301 ...
propidium iodide *1.0 mg/mL solution in water*...
Biology Products: