Navigation Links
New process that may save lives of cancer patients is effective and significantly less costly
Date:8/15/2011

s would uncover virtually all MMR mutations, but the majority of these patients don't have them. Sequencing costs $4,000 to $6,000 per person, so it would be incredibly costly and inefficient to test everyone."

The Intermountain team set out to determine if they could develop a system for screening colon cancer patients with existing tests that could keep costs down, but also ensure accurate results. The team gathered information from a variety of sources, including Intermountain patient data, published literature and outside groups to define the best approach to screening. They came up with a plan that relies on two relatively inexpensive tests to eliminate possible Lynch patients before doing full genome sequencing.

So far, 272 colon cancer patients have been screened according to the group's system, with 261 individuals ruled out as carriers of the abnormal genes.

"That left only 11 patients who we would recommend going forward with the full genome sequencing test," says Dr. Williams. "That represents the wisest use of the expensive resource of full sequencing."

The benefits extend not only to the colon cancer patients, but also to members of their extended families, who may also have the MMR mutation.

"Confirming the Lynch diagnosis changes the way we treat the disease. This form of colon cancer has a generally better prognosis than sporadic colon cancer, but it doesn't respond as well to certain kinds of chemotherapy," says Dr. Williams.

It can also make patients more alert to other forms of cancer, triggering earlier and more frequent screenings. Some women who are diagnosed with Lynch may choose to have surgery to remove the uterus and ovaries to prevent ovarian or uterine cancer.

One unusual aspect of the project was the methodology used to carry it out, says Dr. Williams.

"The team developed customized computer models to examine an assortment of questions that Intermountain decision-mak
'/>"/>

Contact: Jess C. Gomez
jess.gomez@imail.org
801-507-7455
Intermountain Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ancient glacial melting process similar to existing concerns about Antarctica, Greenland
2. 1st large-scale map of a plants protein network addresses evolution, disease process
3. Processes for obtaining ecological compound that can optimize biodiesel enhanced
4. Public prefers limited informed consent process for biobanks
5. Breaking the chain: Molecular cap blocks processes that lead to Alzheimers, HIV
6. Researchers find process of cervical ripening differs between term and preterm birth
7. New technique sheds light on the mysterious process of cell division
8. MIT: Development in fog harvesting process
9. Functional MRI shows how mindfulness meditation changes decision-making process
10. The gene processes that drive acute myeloid leukaemia
11. Brandeis researchers use lasers, custom microscope to show gene splicing process in real time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... their offering. One major trend emerging ... advances in technology, it is important to upgrade biometric ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into your ... the answer to your secret question. What,s your dog,s birthday? Who ... Labs , a digital infrastructure security company, launches the ... comes with usernames, passwords and PINs – 1U TM ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... the most rapidly increasing food production system worldwide through ... 2009 issue of BioScience . The assessment, by ... Ann Arbor, notes that despite well-publicized concerns about ... practiced well, be no more damaging to biodiversity than ...
... has worked out how some newly discovered light sensors ... brain. The report appears online this week in ... small number of nerve cells in the retina that ... retinarods and conesmelanopsin-containing cells are not used for seeing ...
... DNA modification in lung cancer, a team of international researchers ... They say that "silencing" of a single gene in lung ... cells, contributing to cancer development and progression. In the ... journal of the American Association for Cancer Research, they also ...
Cached Biology News:Aquaculture's growth seen as continuing 2Bright lights, not-so-big pupils 2Bright lights, not-so-big pupils 3In lung cancer, silencing one crucial gene disrupts normal functioning of genome 2In lung cancer, silencing one crucial gene disrupts normal functioning of genome 3
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to ... independent consultants, Protocol Networks has recently announced its expansion ... years, his company has attracted several clients in The ... well as others. With the success of these engagements, ...
(Date:1/22/2015)... Pipette.com has added the Eppendorf Centrifuge ... of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 R ... R and receive the following:, ,     Free ... Eppendorf Reference 2 ,     3 Free boxes ...
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently ... Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... education conference for health care professionals. This year’s pre-conference seminar ... probiotics in health. Dr. Leyer spoke about the emerging topics ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... multi-drug ... resistant infections -, NEW HAVEN, Conn., Jan. ... focused on the,development of novel antibiotics for the treatment of antibiotic-resistant,infections, ... 2 clinical trials. The studies will evaluate the safety and,efficacy of ...
... the pharmaceutical and biotechnology ... strengthens specialist expertise, BOSTON, Jan. 3 Observant ... a passion for research excellence,and a commitment to client ... joined the firm as Vice President. Dr. Hartman,s,research has ...
... are using the tiniest organisms on the planet ,bacteria, as ... study featured in the journal Biotechnology and Bioengineering, lead author ... have gained critical insights that may lead to commercialization of ... can use any kind of waste, such as sewage or ...
Cached Biology Technology:Rib-X Pharmaceuticals Initiates Two Phase 2 Studies for Novel Antibiotic Compound RX-1741 2Rib-X Pharmaceuticals Initiates Two Phase 2 Studies for Novel Antibiotic Compound RX-1741 3Observant LLC Expands Senior Management Team 2Life at the jolt 2Life at the jolt 3Life at the jolt 4
UGT1A6 (D-20)...
... The OEM-EPC is the smallest electronic ... x 60 mm. Parker configured this unit ... science OEM markets. Used in carrier gas ... control, liquid dispensing, and hydro-dynamic focusing, the ...
... The P5T Series Short Stroke Thrust ... stroke applications where mounting envelopes are limited ... wear bands and internal bumpers provide millions ... applications., Choice of composite bushings or ...
... Captiva 96-well Filter Plates are offered ... and 0.45 um depth filter plates are ... LC/MS analysis. Filtration is simple, versatile, and ... columns. The Captiva 10 um glass fiber ...
Biology Products: