Navigation Links
New potential to treat chronic obstructive pulmonary disease
Date:1/26/2010

Chronic obstructive pulmonary disease (COPD) is defined by emphysema and/or chronic bronchitis. It destroys the normal architecture of the lung and inhibits the mechanical aspects of breathing, which prevents necessary gas exchange. Patients suffer from coughing fits, wheezing, and increased incidence of lung infections. These symptoms are associated with changes in the architecture of the lung. The air sacs, which usually inflate with air during breathing as they loose their elasticity, becoming rigid and unable to inflate. The lung becomes inflamed and increases its mucus production, which further inhibits gas exchange, and prevents the patient's ability to be physically active.

Although COPD is a leading cause of morbidity and mortality worldwide, there is currently no cure for the disease. Providing patients with concentrated oxygen therapy and instruction on breathing techniques increases survival rates.

In a new study published in Disease Models & Mechanisms (DMM), dmm.biologists.org, collaborative findings by European researchers demonstrate that an antioxidant protein, sestrin, triggers molecular pathways that induce some of the critical lung changes associated with COPD. By genetically inactivating this protein, they were able to improve the elastic features of the lung in a mouse model of emphysema. These authors believe that by inhibiting the antioxidant sestrin protein, they prevent the accelerated degradation of elastic fibers within the lung. This suggests that patients with COPD could benefit from treatment with drugs that block sestrin function.

Although sestrin is an antioxidant protein, the authors found that this characteristic of the protein is not likely to influence its effects on COPD progression in the lung. The negative effects of sestrin on lung elasticity results from its suppression of genes whose products maintain elastin. Elastin makes the lung flexible so that it can expand and contract. Without elastin fibers, the lung becomes rigid and increasingly unable to provide for gas exchange.


'/>"/>

Contact: Kristy Kain
kristy.kain@vanderbilt.edu
615-343-1298
The Company of Biologists
Source:Eurekalert

Related biology news :

1. Potential of dairy-based package wraps outlined
2. Engineered tobacco plants have more potential as a biofuel
3. New science estimates carbon storage potential of US lands
4. Potential new heart attack biomarker uncovered
5. Potential cancer drug may offer new hope for asthma patients
6. New research provides insights into potential ecological costs and cobenefits of REDD
7. Interactions with aerosols boost warming potential of some gases
8. LX211 highlighted as potential disease modifying therapy for non-infectious uveitis
9. Heat forms potentially harmful substance in high-fructose corn syrup
10. Iowa State University researcher uncovers potential key to curing tuberculosis
11. Mechanism for potential Friedreichs ataxia drug uncovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... Jan. 5, 2017  Delta ID Inc., a leader ... technology for automotive at CES® 2017. Delta ID has ... to demonstrate the use of iris scanning as a ... the driver in a car, and as a way ... experience. Delta ID and Gentex will demonstrate ...
(Date:1/3/2017)... Jan. 3, 2017 Onitor, provider of digital ... Onitor Track, an innovative biometric data-driven program designed to ... month at the 2017 Consumer Electronics Show (CES) in ... In the U.S., the World Health Organization (WHO), have ... of adults who are overweight or obese. WHO also ...
(Date:12/20/2016)... Dec. 20, 2016 The rising popularity ... and leasing is stoking significant interest in keyless ... technology, Bluetooth low energy (BLE), biometrics and near-field ... next wave of wireless technologies in the automotive ... to advanced access systems opens the market to ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... ... January 11, 2017 , ... ... with accurate and reliable preimplantation genetic screening (PGS). , “Our genetics and IVF ... says Ovation Fertility Genetics Scientific Director Amy Jones, M.S., ELD (ABB) , ...
(Date:1/11/2017)... ... January 11, 2017 , ... Photonics industry and STEM ... are commending the U.S. Congress and President Obama for their recognition of the ... the American Innovation and Competitiveness Act (AICA). , The language of the act ...
(Date:1/11/2017)... ... 11, 2017 , ... With sepsis claiming approximately 500,000 lives ... billion, healthcare systems are looking to provide better and faster care to ... are bacteria and the yeast pathogen Candida, which can lead to severe complications ...
(Date:1/11/2017)... ... January 11, 2017 , ... Microbial genomics leader uBiome, is ... most recent microbiome impact grant award has been made to Dr. Eon Rios ... use of oral antibiotics, prescribed for skin conditions, on the gut microbiome. ...
Breaking Biology Technology: