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New potential targets discovered for treating squamous cell lung cancers
Date:9/9/2012

t example of a tumor that has a genomic mechanism for evading an immune response," he said. "This may be important in understanding the immune response to squamous cell carcinoma and also in envisioning how immune-regulatory therapy might be used for this disease."

While much works needs to be done, the scientists see many opportunities.

"When we see lung cancer patients, it's almost a double standard. If you have lung adenocarcinoma, we can offer you molecular testing, we can put you in trials, we can put you on some targeted drugs," said Peter S. Hammerman, a co-chair of the paper's writing and analysis committee, an associated researcher at the Broad, a member of the thoracic oncology program and instructor at Dana-Farber and Harvard Medical School. "If you have squamous cell lung cancer, you get the same treatment today you got 10 years ago, which is no more effective than it was 10 years ago. We're just starting to see the first glimmers of hope in squamous cell lung cancer. This paper takes us to the next level in terms of identifying a number of potentially interesting targets to work on."

The Broad's participation in the TCGA network included leadership of three centers: the Genome Sequencing Center, for which Broad Director Eric S. Lander is the principal investigator; one of six Genome Characterization Centers, led by Meyerson; and one of six Genome Data Analysis Centers, led by Gad Getz, director of Cancer Genome Computational Analysis at the Broad, and Broad senior associate member Lynda Chin, formerly at Dana-Farber and now at The University of Texas MD Anderson Cancer Center.

"I think it's the hope of all of us who worked on this study that we'll catalyze a large new set of clinical trials in squamous cell carcinoma," Meyerson said.


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Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

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