Navigation Links
New potential targets discovered for treating squamous cell lung cancers
Date:9/9/2012

Cambridge and Boston, MA. Sunday, September 9, 2012 A new paper published online in Nature holds out hope that people with the second most common type of lung cancer may one day benefit from targeted therapies that have transformed treatments for other lung cancer patients.

Squamous cell lung cancer kills more people each year than breast, colorectal, or prostate cancer, ranking second only to lung adenocarcinoma in the number of deaths it causes. But unlike the most common form of lung cancer, squamous cell carcinoma has no treatments aimed at the specific genetic alterations that drive it.

That picture may change. The Cancer Genome Atlas (TCGA) Research Network, led in part by scientists at the Broad Institute, Dana-Farber Cancer Institute, and Harvard Medical School, has identified many potential therapeutic targets based on the large number and variety of DNA alterations they discovered in most of the tumors they studied.

"This study clearly shows that squamous cell carcinoma, like lung adenocarcinoma, is a cancer with diverse genomic causes, many of which are potentially susceptible to drug inhibition," said Matthew Meyerson, co-leader of the project within TCGA, Broad senior associate member, and professor of pathology at Dana-Farber Cancer Institute and Harvard Medical School. "This provides many new therapeutic opportunities for squamous cell carcinoma that would be suitable for clinical trials."

The first targeted treatments for lung adenocarcinoma, erlotinib (Tarceva) and gefitinib (Iressa), were aimed at mutations in the EGFR gene. Unfortunately, and like other drugs being tested in clinical trials that target several other genes altered in lung adenocarcinoma, they do not help patients with squamous cell carcinoma. The TCGA effort, a multicenter consortium funded by the National Institutes of Health, is the first comprehensive genomic characterization of this lung cancer subtype. Squamous cell carcin
'/>"/>

Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A*STAR scientists discover potential drug for deadly brain cancer
2. BUSM researchers find potential key to halt progression, reverse damage from emphysema
3. Professors Antarctica research shows potential king crab invasion
4. Nematodes with pest-fighting potential identified
5. Ecologist: Genetically engineered algae for biofuel pose potential risks that should be studied
6. Climate change effects, potential mitigation in Northeast forests subject of Forest Service Report
7. Novel nano-structures to realize hydrogens energy potential
8. Potential drug molecule shows enhanced anti-HIV activity
9. Blood vessel forming potential of stem cells from human placenta and umbilical cord blood
10. Researchers discover potential explanation for why a diet high in DHA improves memory
11. UCSB scientists compile first study of potential for tsunamis in northwestern California
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... which over thousands of years has adapted to the arctic ... makes the cold dangerous for you. , This is happening ... the cold provoking substance, called nonylphenol, comes from the use ... of being a endocrine disruptor, but when entering the worm ... to protect the cells in its body from cold damage. ...
(Date:9/18/2014)... deep in the primitive brainstem has revealed how we ... School of Medicine and the University at Buffalo School ... second "sleep node" identified in the mammalian brain whose ... produce deep sleep. , Published online in August in ... half of all of the brain,s sleep-promoting activity originates ...
(Date:9/18/2014)... "frequent flyers" program, fruit flies surely would be eligible ... increasing numbers of fruit fly research studies. One fruit ... and another is scheduled launch to the station Sept. ... December. , Fruit flies are biomedical research models studied ... organisms can reveal the basis for health and disease ...
Breaking Biology News(10 mins):Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3No sedative necessary: Scientists discover new 'sleep node' in the brain 2Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... that shows clear evidence of evolution from lower primates ... well have depended in part on hyperactivation of the ... regulating perception, behavior and memory. , They reported that, ... in a regulatory segment of the prodynorphin gene, which ...
... BioSciences, Inc. today announced that data from its ... were presented at the 45th Annual Interscience Conference ... DC. The study represents the first demonstration ... infection by treatment with Sangamo's proprietary zinc finger ...
... ever wondered how the myriad insect forms—beetles, flies, dragonflies, ... Insects make up 75% of all species known. The ... of a combination of one or more factors: a ... an ability to adapt to new environments and exploit ...
Cached Biology News:Key brain regulatory gene shows evolution in humans 2Key brain regulatory gene shows evolution in humans 3Key brain regulatory gene shows evolution in humans 4Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection 2Islands in the Genome Promote Speciation 2
(Date:9/20/2014)... September 20, 2014 MediVet America ... perform a groundbreaking surgery at the specialized Wolvega Horse ... superficial digital flexor tendon was ruptured 90% and her ... injury is a death sentence for a horse. , ... stem cell treatments . This revolutionary regenerative option ...
(Date:9/19/2014)... Life is rarely simple. From crop yields to disease ... usually those considered "complex traits." Just as for heightthe ... a particular human disease are shaped by multiple genetic ... genes involved. To track down such genes, geneticists typically ... a large mouse and a small mouseand then study ...
(Date:9/19/2014)... that use light, rather than electricity, to move ... energy efficiency is a growing concern as chips, ... components of optical circuits light emitters, modulators, ... build. One promising light source for optical chips ... properties when deposited as a single, atom-thick layer. ...
(Date:9/19/2014)...  An entire month is dedicated to one of ... disease (CMT) – a debilitating neuromuscular disease affecting the ... weakness, and foot and hand deformities. CMT affects 1 ... is a progressive disease, and over time patients lose ... such as leg braces, wheelchairs and scooters to get ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... Oct. 8 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc.,("Oncolytics") ... completed initial scale up of its manufacturing ... scale up of primary production and downstream ... Council Biotechnology,Research Institute (NRC-BRI) located in Montreal, ...
... Matrox Graphics Inc., the leading,manufacturer of specialized graphics ... Xenia(TM) Series display controller boards with its,ME/CCL medical ... native PCI Express single-slot board with,all-digital, triple-monitor output ... Xenia Series supports resolutions from <1MP to,8MP with ...
... a six-year battle with heart disease that included numerous medications, trips to ... found himself in the Intensive Care Unit at an Ohio hospital. Both ... of a transplant. , ... TUCSON, Ariz. (Business Wire EON) October ...
Cached Biology Technology:Oncolytics Biotech Inc. Completes Initial Scale Up of Manufacturing Process for REOLYSIN(R) to Commercial Scale 2Totoku Europe Chooses Matrox Xenia(TM) Series to Drive Medical Monitors 2 "Put Down the BBQ Ribs, We've Found You a Donor Heart," Nurse Tells Patient : Ohio Father near Death Gets Second Chance at Life with CardioWest&#8482; temporary Total Artificial Heart 2
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
CCNI Antibody...
...
...
Biology Products: