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New piece found in the puzzle of epigenetics
Date:6/16/2009

ided with an additional phosphate group. If this is lacking, mRNA will be produced, but not any snRNA. The reason for that is presumably that this phosphorylation enables the interaction with a protein complex the so-called integrator complex which is necessary for snRNA formation. In other words, the modification of the enzyme RNA polymerase II at defined positions regulates whether this enzyme can produce certain kinds of RNA molecules or not.

In their latest research, the scientists led by Dirk Eick showed that the enzyme TFIIH kinase is responsible for the selective phosphorylation of RNA polymerase II. "With these findings another building block has been identified that plays a key role in epigenetic regulation by means of RNA polymerase II," Professor Eick said. "This is of great significance because knowledge of epigenetic mechanisms is necessary in order to better understand cancer and other diseases and to be able to provide more targeted treatment."


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Contact: Sven Winkler
sven.winkler@helmholtz-muenchen.de
49-089-318-73946
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

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