Navigation Links
New perspective needed for role of major Alzheimer's gene
Date:5/7/2013

d how the harmful forms of APOE increase risk of the disease.

"APOE is a major player in Alzheimer's, there's no question about that," said Philip Verghese, PhD, a postdoctoral research associate. "We did some additional studies in mice and cell cultures that suggested the APOE protein may be blocking a pathway that normally helps degrade amyloid beta."

APOE is involved in the metabolism of fats, cholesterol and vitamins throughout the body. Scientists have identified three different forms of the gene that each make a slightly different version of the protein.

One version, APOE 2, produces a protein that significantly reduces Alzheimer's risk. Another, APOE 4, increases risk. Each person has two copies of the gene, and if both copies are APOE 4, the chance of developing Alzheimer's rises dramatically.

"About 60 percent of the patients we see in the Alzheimer's clinics have at least one copy of APOE 4," Holtzman said. "In contrast, only about 25 percent of cognitively normal 70-year-olds have a copy of APOE 4."

Verghese tested cerebrospinal fluid samples from people who had either two copies of APOE 4 or two copies of APOE 3, another form of the gene that is not associated with increased Alzheimer's risk.

"We also found that APOE 2, the protective form of the protein, doesn't bind to amyloid beta in body fluids," Verghese said.

In follow-up studies, Verghese showed that APOE and amyloid beta "compete" to bind to a receptor on support cells in the brain known as astrocytes.

"Studies by other researchers have shown that astrocytes can degrade amyloid beta," Verghese said. "The receptor we identified may be important for getting amyloid beta into the astrocyte so it can be broken down. It's possible that when the harmful forms of APOE bind to the receptor, this reduces the opportunities for amyloid to be degraded."

The researchers are planning follow-up studies of the effects of APOE-bl
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bridges experimental and bioinformatics perspectives to delineate protein-DNA interactions
2. Individual perspectives improve laparoscopy
3. The future of plant science a technology perspective
4. The future of plant science - a technology perspective
5. Online biodiversity databases audited: Improvement needed
6. Stronger support needed for healthy beverage practices in child care
7. Better estrogen-testing methods needed to improve patient care
8. Safeguards needed for tissue donors
9. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
10. More evidence needed to support use of autism interventions
11. Action needed to prevent more devastating tree diseases entering the UK
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/3/2014)... from Australia report that low birth weight and preterm ... hip replacements in adulthood. Findings published in the American ... Research , indicate that low birth weight and pre-term ... due to OA as adults. , According to ... 25 are diagnosed with clinical OA. Symptoms of OA ...
(Date:11/2/2014)... (2 November 2014)—In support of a bold quest to ... Melinda Gates Foundation today announced an award of US$156 ... Initiative (MVI) in building new vaccines that will interrupt ... the "accelerating to zero" agenda. Such vaccines would ensure ... be called an "immunological bed net." , This ...
(Date:11/2/2014)... a bar and bump into a biologist . . . ... late-night nerd sketch, researchers have taken this premise and applied ... finding meaning in the rising oceans of genomic data. , ... that genome-wide studies are publishing at a dizzying rate. The ... signal from the noise (and there is no shortage of ...
Breaking Biology News(10 mins):Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4Mutant models 2Mutant models 3Mutant models 4
... patients miserable and debilitated with chronic itching or pain ... possible paralysis or damage to the brain and other ... effective treatment even though the responsible gene was identified ... done to treat a disease that affects more people ...
... have identified a specific protein molecule that is used ... leading the way for development of future vaccines to ... issue of Science Express, the study provides insight into ... problem of great scientific and clinical importance. , Most ...
... field trials in China report higher crop yields, reduced ... a study by researchers in China and at Rutgers ... of the study will appear in the April 29 ... two of the four GM varieties that are now ...
Cached Biology News:Potential treatments for neurofibromatosis 2Potential treatments for neurofibromatosis 3Yale researchers identify molecule for detecting parasitic infection in humans 2Genetically modified rice in China benefits farmers' health, study finds 2Genetically modified rice in China benefits farmers' health, study finds 3Genetically modified rice in China benefits farmers' health, study finds 4
(Date:11/27/2014)... Massachusetts, USA (PRWEB) November 26, 2014 ... more accuracy, additive systems to enable 3D manufacture at ... analyzing road conditions are among finalists in nine categories ... . The awards are sponsored by SPIE, the ... Photonics Media . , Winners will be announced by ...
(Date:11/26/2014)... In keeping with the holiday spirit, DNA ... Thanksgiving savings. The company is offering up a variety ... this holiday weekend as well as a photo contest ... Monday are right around the corner, and DNA Spectrum ... and those looking to explore their ancestry, health, and ...
(Date:11/26/2014)... 2014 The ETC (Emerging Technology ... innovation centers, announced today that applications for AccelerateBaltimore™ ... 1st. “Do you have a big idea?,” asked ... to know about it. AccelerateBaltimore helps you and ... in just 13 weeks.” Interested game changers ...
(Date:11/26/2014)... 2014 Continuing its award-winning streak, Nerium ... prestigious MarCom Awards for outstanding creative achievement by its ... MarCom Award, the organization’s top honor, in the Branding ... held in April of this year. The event showcased ... Additionally, Nerium was awarded a Gold MarCom Award in ...
Breaking Biology Technology:Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
... FRANCISCO, March 11 VIA Pharmaceuticals,(Nasdaq: VIAP ... of,compounds for the treatment of cardiovascular disease, announced ... James G. Stewart, senior,vice president and chief financial ... Cowen and Company 28th Annual Health Care Conference ...
... Sunesis,Pharmaceuticals, Inc. (Nasdaq: SNSS ), a clinical-stage ... of,novel small-molecule therapeutics, today reported financial results for ... Total revenue for the fourth quarter of ... $8.8 million. Total revenue for the year ended ...
... N.J., March 11 Pharmacopeia,(Nasdaq: PCOP ), an ... therapeutics, today announced that Dr. Leslie J. Browne,President and ... Cowen and Company 28th Annual Health Care Conference.,The conference ... The Boston Marriott,Copley Place, Boston, Massachusetts., Dr. Browne,s ...
Cached Biology Technology:Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 2Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 3Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 4Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 5Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 6Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 7Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 8Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 9Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2007 Financial Results 10Pharmacopeia to Present at the Cowen and Company 28th Annual Health Care Conference 2Pharmacopeia to Present at the Cowen and Company 28th Annual Health Care Conference 3