Navigation Links
New pathway discovered that may prevent tissue damage resulting from inflammation
Date:12/23/2009

(New York, New York December 22, 2009): Interferon gamma is a protein secreted by lymphocytes that is used to fight the bacteria in white blood cells that cause tuberculosis. In a study published this week in Immunity, scientists at NYU Langone Medical Center have discovered that in addition to white blood cells, other cells such as epithelial and endothelial cells, also respond to interferon gamma and also protect mice from uncontrolled tuberculosis infection. This new pathway could lead to the developments of treatments that could limit or prevent tissue damage resulting from inflammation.

"Through research on tuberculosis, we discovered a new way that the immune system response is controlled," said lead author Joel Ernst, MD, director of the Division of Infectious Diseases and the Jeffrey Bergstein Professor of Medicine at NYU Langone Medical Center. "Further study may reveal treatments that could be useful in control of inflammation and tissue damage in certain infections and autoimmune diseases."

In this study, researchers looked at interferon gamma responses in epithelial and endothelial cells to control tuberculosis in mice. Cells such as epithelial and endothelial cells were found to respond to interferon gamma by producing an enzyme, indolelamine-2-3-dioxygenase (IDO), that converts the amino acid tryptophan to products called kynurenines. These kynurenines inhibit the production of Th17 cells, the lymphocytes that contribute to tissue-damaging inflammation.


'/>"/>

Contact: Lorinda Klein
lorindaann.klein@nyumc.org
212-404-3533
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

0

GOOD

Page: 1

Related biology news :

1. Researchers identify new brain pathway for regulating weight and bone mass
2. Scientific pathways into the nanoworld
3. UCSF researchers identify 2 key pathways in adaptive response
4. UCLA researchers discover new molecular pathway for targeting cancer, disease
5. Trans fats hinder multiple steps in blood flow regulation pathways
6. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
7. ISU researcher identifies genetic pathway responsible for much of plant growth
8. Identification of a key molecular pathway required for brain neural circuit formation
9. Computational model examines the pathways of Alzheimers that strikes at the young
10. Computational model examines the pathways of Alzheimers that strikes at the young
11. New drug agent knocks out multiple enzymes in cancer pathway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... Studying complex systems like ecosystems can get messy, ... other big unknowns like climate change. , In ... the Proceedings of the National Academy of Sciences ... validate a fundamental assumption at the very heart of ... , To model how climate changes may impact biodiversity, ...
(Date:5/24/2013)... 24, 2013 A frequently expressed concern in the ongoing ... fresh vegetables, especially those that are nutrient dense. ... and Beans Provide Most Nutrients Per Penny," published in ... are one of the best nutritional values in the ... per penny than most other raw vegetables and delivering ...
(Date:5/24/2013)... fastest growing open-access publishers, today announces the launch of ... A broad scope journal covering all specialties, Frontiers ... web platform for the research community to publish high ... and interactive peer-review enables fast, fair and constructive review ... of three months from submission to final decision for ...
Breaking Biology News(10 mins):Understanding the past and predicting the future by looking across space and time 2New research shows that potatoes provide one of the best nutritional values per penny 2Frontiers launches new open-access journal in physics 2Frontiers launches new open-access journal in physics 3
... new understanding of the process cells use to ensure ... copy of each chromosome ?a process that must be ... mental retardation. The new work reveals how gluelike protein ... of meiosis ?the specialized cell division process that produces ...
... calpain can be the key either preventing or promoting the ... "This work provides proof in principle that pharmacological inhibition of ... where this is not desirable, such as in neuronal cells ... in cancer cells where this is clearly a very desirable ...
... rat under stress and what does it do? It ... suffer nontraumatic stress they often head for the refrigerator, ... are normally solitary, are placed in a group-living situation, ... for Behavioral Neuroscience at Georgia State University are using ...
Cached Biology News:What controls stickiness of 'smart' chromosomal glue 2What controls stickiness of 'smart' chromosomal glue 3What controls stickiness of 'smart' chromosomal glue 4Protein's role in regulating cell death sets direction for cancer research 2Just like us, social stress prompts hamsters to overeat, gain weight 2Just like us, social stress prompts hamsters to overeat, gain weight 3Just like us, social stress prompts hamsters to overeat, gain weight 4
(Date:5/25/2013)... 2013 Significant research in quantum optics, ... recognized with presentation of awards by the International ... 16 April during the SPIE Optics and Optoelectronics 2013 ... optics and photonics , is an International Society Member ... was presented with the 2011 ICO Galileo Galilei Award, ...
(Date:5/25/2013)... 25, 2013 Dennis R. HIll M.D. Radiation ... CA reports that recently there has been a promotion of ... improved the permanent seed, or low dose rate, brachytherapy for ... a higher energy, a shorter half life, and gives a ... that Cesium 131 has a higher average energy than the ...
(Date:5/24/2013)... Dr. Ingrid Warmuth and Anamaria Newport, MHS, PA-C, with ... announce an Open House at their Swedesboro location, 95 Woodstown ... from 10 AM to 2 PM. , During the ... will be on hand to talk to people about the ... complimentary cosmetic consultations. There will also be specials offered, such ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 In ... and industry suppliers will present technologies with applications ... the annual SPIE Optics and Photonics ... by SPIE, the international society for optics ... international, multidisciplinary optical sciences and technology meeting in ...
Breaking Biology Technology:ICO Honors Three with Awards during SPIE Optics and Optoelectronics 2ICO Honors Three with Awards during SPIE Optics and Optoelectronics 3Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 2Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 2See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 4
... configured specifically for pharmaceutical powder packaging, ... are precision-joined to create ultra-smooth surfaces ... and disinfect. One-inch radius corners simplify ... strong, rigid surface without external bracing. ...
... Phosphate Sensor is a highly sensitive ... This product is a purified form of ... the fluorophore MDCC, which is sensitive to ... inorganic phosphate by Phosphate Sensor is rapid ...
... ductless exhaust hood ventilates and purifies ... release of exhaust. Bonded charcoal filters ... of vertical clearance (with access shield ... spill tray; options include final HEPA ...
... ideal modular cleanroom for biological safety ... require cleanliness (to Class 10/ISO 3) ... to create ultra-smooth surfaces that are ... One-inch radius corners simplify cleaning. Unique ...
Biology Products: