Navigation Links
New pathway discovered that may prevent tissue damage resulting from inflammation
Date:12/23/2009

(New York, New York December 22, 2009): Interferon gamma is a protein secreted by lymphocytes that is used to fight the bacteria in white blood cells that cause tuberculosis. In a study published this week in Immunity, scientists at NYU Langone Medical Center have discovered that in addition to white blood cells, other cells such as epithelial and endothelial cells, also respond to interferon gamma and also protect mice from uncontrolled tuberculosis infection. This new pathway could lead to the developments of treatments that could limit or prevent tissue damage resulting from inflammation.

"Through research on tuberculosis, we discovered a new way that the immune system response is controlled," said lead author Joel Ernst, MD, director of the Division of Infectious Diseases and the Jeffrey Bergstein Professor of Medicine at NYU Langone Medical Center. "Further study may reveal treatments that could be useful in control of inflammation and tissue damage in certain infections and autoimmune diseases."

In this study, researchers looked at interferon gamma responses in epithelial and endothelial cells to control tuberculosis in mice. Cells such as epithelial and endothelial cells were found to respond to interferon gamma by producing an enzyme, indolelamine-2-3-dioxygenase (IDO), that converts the amino acid tryptophan to products called kynurenines. These kynurenines inhibit the production of Th17 cells, the lymphocytes that contribute to tissue-damaging inflammation.


'/>"/>

Contact: Lorinda Klein
lorindaann.klein@nyumc.org
212-404-3533
NYU Langone Medical Center / New York University School of Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers identify new brain pathway for regulating weight and bone mass
2. Scientific pathways into the nanoworld
3. UCSF researchers identify 2 key pathways in adaptive response
4. UCLA researchers discover new molecular pathway for targeting cancer, disease
5. Trans fats hinder multiple steps in blood flow regulation pathways
6. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
7. ISU researcher identifies genetic pathway responsible for much of plant growth
8. Identification of a key molecular pathway required for brain neural circuit formation
9. Computational model examines the pathways of Alzheimers that strikes at the young
10. Computational model examines the pathways of Alzheimers that strikes at the young
11. New drug agent knocks out multiple enzymes in cancer pathway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/22/2017)... LIVERMORE, Calif. , March 21, 2017 ... recognition analytics company serving law enforcement agencies, announced today ... Sheridan as director of public safety business development. ... of diversified law enforcement experience, including a focus on ... Vigilant. In his most recent position, Mr. Sheridan served ...
(Date:3/13/2017)... March 13, 2017 Future of security: Biometric Face Matching ... ... DERMALOGs Face Matching enables to match face pictures against each ... to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching on ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... WEST BOUNTIFUL, Utah (PRWEB) , ... May 24, ... ... announces the selection and implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient ... is a key component of a $24 million plant upgrade to sustainably meet ...
(Date:5/24/2017)... -- As Ebola resurfaces in the Democratic Republic ... cases now reported, a new analysis of the Ebola gene ... between the 2014 and 2017 outbreaks of the disease.  ... which preceded the 2014 outbreak. An analysis of the latest ... in 2014-15, which again precedes the current outbreak in the ...
(Date:5/23/2017)... Switzerland (PRWEB) , ... May 23, 2017 , ... ... R&D, celebrates this month its 20th anniversary, marking the occasion with a strong ... sponsoring the meeting’s Welcome Reception and further extends an invitation to all attendees ...
(Date:5/23/2017)... ... May 23, 2017 , ... Energetiq Technology, a ... a facility expansion to accommodate its rapid growth. , The renovations at the ... renovation of the existing areas. The expansion includes, a state-of-the-art engineering facility, and ...
Breaking Biology Technology: