Navigation Links
New paradigm for cell-specific gene delivery
Date:6/22/2008

avid Dean, "The benefit of our newly described approach is that it can target specific cell types. One of the most commonly envisioned treatments for these proliferative disorders is to deliver genes that kill or inhibit the dividing smooth muscle cells, but we need to target only these muscle cells and not any other cell in the vessel wall and this approach will enable us to do just that". The goal of the team is to design more effective gene therapy vectors for use in the vasculature by understanding the molecular mechanisms by which DNA and DNA-protein complexes are actively transported into the nucleus. Dr. Warren Zimmer states "these results set the stage for our future use of this technology to deliver therapeutic genes to lessen the severity of restenosis which is the most common issue following angioplasty and placement of stents". Dr. Dean continues, "Now that we have demonstrated proof of principle for this approach we can look for DNA sequences that act in other tissues and develop cell-specific treatments for any number of organs". Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, stated "The exciting studies reported here are the first to demonstrate that non-viral gene delivery can be made cell-specific by controlling the nuclear entry of plasmid DNA, and as such, establishes a new paradigm for cell-selective gene delivery. Drs. Dean, Young, and Zimmer are to be congratulated on this ground-breaking study".


'/>"/>

Contact: Dr. David Dean
david_dean@urmc.rochester.edu
585-276-3933
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Lets talk -- new paradigms in the research of the biomolecular composition of water
2. Paradigm shift in Alzheimerss research: new treatments
3. Test of bacteria toxin delivery system could pave way for new antibiotic drugs
4. MIT: Stripes key to nanoparticle drug delivery
5. Micro-origami: USC folds up micrometer-scale voxels for drug delivery
6. Fewer babies born after Caesarean delivery
7. Remarks Prepared for Delivery By Attorney General Michael B. Mukasey At the Ministerial Press Conference
8. e-SMART Technologies Continues Delivery of Its New Super SMART Card in South Korea
9. Researchers develop better membranes for water treatment, drug delivery
10. Carnegie Mellon researchers to develop new drug delivery system
11. Computer solution to delivery problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... American singles found that during sex with a ... On average, men experience orgasm 85.1 percent of ... difference. For women, however, orgasm occurrence is less ... of the time during sex with a familiar ... sexual orientation, with lesbian women experiencing orgasm more ...
(Date:8/21/2014)... unknown process for harvesting energy and producing oxygen from ... University scientist has discovered. The discovery lays the foundation ... energy from the Sun, and understanding dense blooms like ... worldwide. A paper describing the discovery will be published ... journal Science on 21 August 2014. , ...
(Date:8/21/2014)... linked to dandruff, eczema and other itchy, flaky maladies ... global reachesincluding Hawaiian coral reefs and the extreme environments ... review in the scientific journal PLOS Pathogens ... of the genus Malassezia in light of ... around the world. , University of Hawai,i at Mānoa ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... of Biological Sciences (AIBS) and the National Evolutionary ... and workshop for educators at the National Association ... The special symposium, which has become a ... classroom teachers with an opportunity to hear directly ...
... Research and Forestry Applications (CREAF), in the celebration of ... of international experts to discuss the environmental future of ... The work of both days is summarized in the ... Sustainability, which you will find bellow. Targeted to governments ...
... in age-related macular degeneration, the most common cause of ... today in the Lancet , adds to the ... (AMD), which the researchers believe should ultimately lead to ... people aged 80 years or older are affected by ...
Cached Biology News:Illuminating biology: An evolutionary perspective 2Illuminating biology: An evolutionary perspective 3Illuminating biology: An evolutionary perspective 4Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability 2Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability 3Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability 4Genetic finding implicates innate immune system in major cause of blindness 2
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
(Date:8/21/2014)... 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products marketed as XIAFLEX ® ... U.S. and XIAPEX ® in the EU, ... randomized, double-blind Phase 2a study of CCH for ... panniculopathy. The results showed that all three doses ...
(Date:8/21/2014)... DESY scientists has observed tiny quantum vortices in cold ... journal Science that the exotic vortices arrange ... is the first time that the quantum vortices, which ... is known as superfluid helium, have been detected in ... Andrey Vilesov of the University of Southern California, one ...
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands ... His Majesty Willem-Alexander, King of the Netherlands, has announced ... POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in ... will take part in the Grand Opening Ceremony to ... p.m. and tour the plant. POET-DSM is a joint ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Scientists observe quantum vortices in cold helium droplets 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... Treatment Approved by the Fda For Hypotrichosis of,Eyelashes ... and Drug Administration (FDA) has approved LATISSE(TM),(bimatoprost ophthalmic ... the eyelashes. Eyelash hypotrichosis is another name for,having ... first and only,FDA-approved, science-based treatment to enhance eyelash ...
... WALTHAM, Mass., Dec. 26 Interleukin Genetics, Inc. (NYSE ... 2008 the Company received notice from the NYSE Alternext ... is not in compliance with certain conditions of the ... Company Guide. Specifically, the Exchange noted the Company,s failure ...
... Minimize Viral Transmission, Including Norovirus , A ... public health by minimizing the transmission of multiple ... providers. The researchers from the University of ... Raleigh report their findings in the August 2008 ...
Cached Biology Technology:MultiVu Video Feed: U.S Food and Drug Administration (Fda) Approves Latisse(TM) -- 2MultiVu Video Feed: U.S Food and Drug Administration (Fda) Approves Latisse(TM) -- 3Interleukin Genetics Receives Notification of Failure to Meet Continued Listing Standard Section 1003(a)(iii) 2Interleukin Genetics Receives Notification of Failure to Meet Continued Listing Standard Section 1003(a)(iii) 3Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4
Large-capacity refrigerated incubator chamber holds up to 4 independently-operated shakers. Programmable heat, refrigeration, humidifcation are standard. Photosynthetic operation, optional....
Denhardt's powder mixture (for 50X stock solution)...
... for monitoring acetylcholinesterase (AChE) activity. This is ... 5 min), non-radioactive and easy to use ... natural substrate, acetylcholine. A series of coupled ... AChE into a change in luminescence. Inhibitors ...
Rabbit polyclonal to Vitronectin ( Abpromise for all tested applications). Antigen: Full length Vitronectin protein (Mouse). Entrez Gene ID: 7448 Swiss Protein ID: P04004...
Biology Products: