Navigation Links
New paradigm for cell-specific gene delivery
Date:6/22/2008

avid Dean, "The benefit of our newly described approach is that it can target specific cell types. One of the most commonly envisioned treatments for these proliferative disorders is to deliver genes that kill or inhibit the dividing smooth muscle cells, but we need to target only these muscle cells and not any other cell in the vessel wall and this approach will enable us to do just that". The goal of the team is to design more effective gene therapy vectors for use in the vasculature by understanding the molecular mechanisms by which DNA and DNA-protein complexes are actively transported into the nucleus. Dr. Warren Zimmer states "these results set the stage for our future use of this technology to deliver therapeutic genes to lessen the severity of restenosis which is the most common issue following angioplasty and placement of stents". Dr. Dean continues, "Now that we have demonstrated proof of principle for this approach we can look for DNA sequences that act in other tissues and develop cell-specific treatments for any number of organs". Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, stated "The exciting studies reported here are the first to demonstrate that non-viral gene delivery can be made cell-specific by controlling the nuclear entry of plasmid DNA, and as such, establishes a new paradigm for cell-selective gene delivery. Drs. Dean, Young, and Zimmer are to be congratulated on this ground-breaking study".


'/>"/>

Contact: Dr. David Dean
david_dean@urmc.rochester.edu
585-276-3933
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Lets talk -- new paradigms in the research of the biomolecular composition of water
2. Paradigm shift in Alzheimerss research: new treatments
3. Test of bacteria toxin delivery system could pave way for new antibiotic drugs
4. MIT: Stripes key to nanoparticle drug delivery
5. Micro-origami: USC folds up micrometer-scale voxels for drug delivery
6. Fewer babies born after Caesarean delivery
7. Remarks Prepared for Delivery By Attorney General Michael B. Mukasey At the Ministerial Press Conference
8. e-SMART Technologies Continues Delivery of Its New Super SMART Card in South Korea
9. Researchers develop better membranes for water treatment, drug delivery
10. Carnegie Mellon researchers to develop new drug delivery system
11. Computer solution to delivery problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... GAINESVILLE, Fla. --- By tracing nearly 3,000 genes ... moths, University of Florida scientists have created an ... to use large-scale, next-generation DNA sequencing. , ... more closely related to small moths than to ... how butterflies evolved. The study also found that ...
(Date:7/31/2014)... NCT00518336) shows the sustained efficacy, immunogenicity and ... vaccine Cervarix. Women vaccinated with the HPV-16/18 ... nine years, and vaccine efficacy (VE) against ... longest follow-up report for a licensed HPV ... full paper. , HPV and vaccination ...
(Date:7/31/2014)... This news release is available in German . ... (MOFs) can take up gases similar to a sponge ... are suited for storing hydrogen or greenhouse gases. However, ... of Karlsruhe Institute of Technology (KIT) now report in ... by cor-rosion of the MOF surface. This can be ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3Free pores for molecule transport 2
... 2012 Scientists from the Florida campus of The Scripps ... the National Institute on Drug Abuse of the National Institutes ... relapse in smokers who are kicking the habit. The ... is designed to support an institutionally based research program with ...
... fish species can decline while others may grow, reveals new ... in fish. The gastrointestinal system in fish is much ... even be a limiting factor for the distribution of species, ... looking at how gut function in various fish species is ...
... Conn., May 14, 2012 /PRNewswire-iReach/ -- Global ... reports on RNA interference (RNAi) and its relationship with ... Global Industry Analysts, new RNA Interference ... forecasts for drug discovery and target validation, reagents, and ...
Cached Biology News:Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments 2The gut could reveal effect of climate change on fish 2Understanding the RNAi Reagents Market Overlap with Drug Discovery and Therapeutic Development is Critical for Pharmaceutical Leaders 2
(Date:7/31/2014)... , the leading life sciences employment and news website, launched the ... Illinois , Indiana , ... , Minnesota , Missouri , ... Wisconsin . BioMidwest is a leader in biotech and ... in this region in 2013. The life sciences sector in this area ...
(Date:7/31/2014)... a good reason people over 60 are not donor ... and weakens with time, making the elderly prone to ... Francisco research team now has discovered a reason why. ... the inability of blood-forming cells to maintain blood production ... molecular defects that could be restored for rejuvenation therapies," ...
(Date:7/31/2014)... see through organs and even the entire body to ... cellular structures has been a long-time dream of biologists. ... 31st in the journal Cell has now ... making opaque organs, bodies, and human tissue biopsies transparent, ... protocols could pave the way for a better understanding ...
(Date:7/31/2014)... BLOOMINGTON, Ind. -- Chemists at Indiana University Bloomington ... in bricks-and-mortar fashion, a development with potential value ... as field-effect transistors and photovoltaic cells. , Their ... 3D Crystalline Solids and 2D Self-Assembled Crystals," has ... a journal of the Royal Society of Chemistry. ...
Breaking Biology Technology:Midwest Biotech Leaders Featured On BioSpace Map 2Key to aging immune system is discovered 2See-through organs and bodies will accelerate biomedical discoveries 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3
... 16 The Endocrine Society, an,international association focused on ... analysts. The call,originated from ENDO 08, the annual conference ... Francisco. The Society has over 14,000 members from 80,countries, ... the latest,advances in endocrine research and clinical care., ...
... Anesiva,Inc. (Nasdaq: ANSV ) today announced the appointment ... a member of the company,s board of,directors, effective June ... as chief executive officer and member of the Anesiva ... to the,company., "Michael is the ideal person to ...
... today announced,the appointment of Rudy Mazzocchi as its ... responsible for leveraging the company,s novel,technology to find ... with,impaired vision have access to NovaVision(R) Vision Restoration ... bringing new medical technologies,and devices to market that ...
Cached Biology Technology:'Breakthroughs Ahead,' Endocrine Society Tells Security Analysts 2Anesiva Names Michael L. Kranda as President, Chief Executive Officer and Member of Its Board of Directors 2Anesiva Names Michael L. Kranda as President, Chief Executive Officer and Member of Its Board of Directors 3NovaVision Appoints Medical Technology Veteran Rudy Mazzocchi as Chief Executive Officer 2NovaVision Appoints Medical Technology Veteran Rudy Mazzocchi as Chief Executive Officer 3
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Invasion Assay is designed to determine the ... a significant barrier to invasion or to ... a convenient, high-throughput, 96-well format. The 8 ... types of adherent cells such as epithelial, ...
... GrabIt™ Kits are designed for the study ... a pull-down method. Proteins that interact with ... fusion proteins are copurified using affinity resins ... retained on a spin filter. The complexes ...
Kit containing MACS equipment and reagents for immunopurification of proteins....
Biology Products: