Navigation Links
New paradigm for cell-specific gene delivery
Date:6/22/2008

Researchers from Northwestern University and Texas A & M University have discovered a new way to limit gene transfer and expression to specific tissues in animals. In studies to determine how plasmids enter the nuclei of non-dividing cells, the group previously identified a region of a smooth muscle cell-specific promoter that was able to mediate nuclear targeting of any plasmid carrying this sequence uniquely in cultured smooth muscle cells but in no other cell type. In their current study to appear in the July 08 issue of Experimental Biology and Medicine, the team, led by Drs. David Dean and Jennifer Young from the Department of Medicine at Northwestern University, in collaboration with Warren Zimmer from Texas A & M University, now demonstrate that such restriction of nuclear entry using this specific DNA sequence can be used in blood vessels of living animals to direct gene transfer and expression specifically to smooth muscle cells. They have also developed a novel gene delivery approach for the vasculature that uses an electric field to transiently permeabilize the plasma membrane of cells to allow entry of DNA. Thus, this work establishes the control of nuclear entry of gene therapy vectors as a novel approach to target genes and gene expression to desired cell types in the body.

Vascular smooth muscle proliferative diseases, including atherosclerosis and restenosis, are among the leading causes of morbidity and mortality in the US. Gene therapy may represent an important alternative for the treatment and prevention of these proliferative diseases of the vasculature. It can be highly cell-specific, mimic or restore normal in vivo function, and can be permanent or transient depending on vector design. Currently, a number of gene delivery systems for use on the arterial wall are being studied, but as yet their low efficiency in gene transfer and lack of cell-specific targeting and expression are major limitations. According to Dr. D
'/>"/>

Contact: Dr. David Dean
david_dean@urmc.rochester.edu
585-276-3933
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Lets talk -- new paradigms in the research of the biomolecular composition of water
2. Paradigm shift in Alzheimerss research: new treatments
3. Test of bacteria toxin delivery system could pave way for new antibiotic drugs
4. MIT: Stripes key to nanoparticle drug delivery
5. Micro-origami: USC folds up micrometer-scale voxels for drug delivery
6. Fewer babies born after Caesarean delivery
7. Remarks Prepared for Delivery By Attorney General Michael B. Mukasey At the Ministerial Press Conference
8. e-SMART Technologies Continues Delivery of Its New Super SMART Card in South Korea
9. Researchers develop better membranes for water treatment, drug delivery
10. Carnegie Mellon researchers to develop new drug delivery system
11. Computer solution to delivery problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:12/4/2014)... Dec. 3, 2014  Crossmatch™, a leading provider ... its DigitalPersona ® Pro Enterprise software and ... deployed throughout First Bank branch locations in ... Carolina and Virginia. First Bank, a progressive ... Pines, North Carolina , selected the Crossmatch ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... foodie fashion and look set to become big business in the ... produced by some chickens is prettier and some say tastier and ... scientists from The University of Nottingham, we know what caused the ... a four-year research project just published in the journal, PLOS ...
... exposed to heavy traffic pollution or smoke from wood fire ... of Melbourne led study has found. The study is ... traffic pollution and wood smoke from heaters on middle-aged adults ... asthma and were exposed to heavy traffic pollution experienced an ...
... Aug. 20, 2013 Based on its recent ... Frost & Sullivan presents TATAA Biocenter with the ... Value Leadership. TATAA Biocenter offers an end-to-end range ... reverse transcription polymerase chain reaction (qRT-PCR) to nucleic ...
Cached Biology News:Unscrambling the genetics of the chicken's 'blue' egg 2Traffic pollution and wood smoke increases asthma in adults 2Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 2Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 3Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 4Frost & Sullivan Recognizes TATAA Biocenter's Complete, Best-in-Class Services for Analyzing Genetic Material 5
(Date:12/19/2014)... 18, 2014 Egenix, Inc. is pleased to announce ... of the Board, to succeed Donald Fresne ; Mr. ... continue as a member of the Board.  In recognition of ... the company over almost twenty years, the Board designated Mr. ... Directors has established a Search Committee to find a suitable ...
(Date:12/17/2014)... The Activated Carbon Manufacturing ... why IBISWorld updated its original industry research report. ... an intensified focus on environmental policy. Over the five ... for power plants and a range of other industrial ... Analyst Sarah Kahn, “a range of downstream industrial sectors ...
(Date:12/17/2014)... Achim Noack has been named global vice president ... position, Noack will assist Jerry Stoller, CEO and president ... and supervise global marketing management and implementation of new ... and experience in the crop protection industry,” says Jerry ... thinking will be a great asset for Stoller Group, ...
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
Breaking Biology Technology:Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 22020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2
... a real quandary this week: I have a number of ... recent participation in the annual Israel biotech/medical device conference (BIOMED ... insights into the Indian biotech market, happenings in Japan, and ... , ,I also started thinking back on why I originally ...
... Racine, Wis. - Adapting military research on hydrogen-powered ... appear a little more environmentally friendly, but only after ... pull over to rest, many leave their engines idling ... over 500,000 heavy-duty diesel trucks on U.S. roads today, ...
... technology can help drive a community's economic future often begins ... sense. , ,Unless a community or region has a major ... the nation's next biotechnology "hot spot," even if free land ... states, including Wisconsin, scrambling to find the right niche within ...
Cached Biology Technology:The world of in-vitro diagnostics is another Midwest success story 2The world of in-vitro diagnostics is another Midwest success story 3The world of in-vitro diagnostics is another Midwest success story 4The world of in-vitro diagnostics is another Midwest success story 5The world of in-vitro diagnostics is another Midwest success story 6Modine adapts military research to idling engines 2Modine adapts military research to idling engines 3Technology in the Northwoods 2Technology in the Northwoods 3
... 14 3C protease from human rhinovirus (HRV ... Novagen brand line of restriction grade proteases. ... recombinant 6XHis-fusion protein, which recognizes the same ... The small, 22 KDa size of the ...
Lyophilized. Purity: ≥90% by electrophoresis. Reconstitute in 0.3% NaCl. Prepared from serum that has been shown by certified tests to be negative for HBsAg and for HIV and HCV antibodies. ...
... Polymerase I Large (Klenow) Fragment, Exonuclease Minus, ... both the 5´→3´ and the 3´→5´ exonuclease ... Polymerase I (1,2). It is used for ... displacement amplification (5). Klenow Fragment, Exonuclease Minus, ...
SMVT (N-14)...
Biology Products: