Navigation Links
New papers offer insights into process of malarial drug resistance
Date:11/26/2008

Malaria, one of the oldest diseases known to man, has shown no signs of slowing down as it ages. More than 1 million children die from malaria in sub-Saharan Africa each year, and in areas along the Thailand/Cambodian border multiple drug-resistant strains of the disease are becoming commonplace.

With the previously mainstay antimalarial drug chloroquine nearly ineffective due to drug resistance and traditional public health approaches such as mosquito netting offering uneven results, two new papers by University of Notre Dame biologist Michael Ferdig suggest that the means of combating this old foe may lie in the new tools of genomics and bioinformatics.

In the papers, Ferdig points out that development of the malaria parasite Plasmodium falciparum in the blood is driven by a number of different genes expressed at different times and at different levels. Exactly what influences such transcriptional changes remains elusive, particularly in regard to important phenotypes like drug resistance.

Ferdig and his collaborators combined classical genetics with cutting-edge genomic methods to illuminate previously unrecognized transcriptional complexity and variation in Plasmodium falciparum and possibly master regulators within large copy number variants that contribute to the drug-resistant phenomena in malaria parasites.

By uncovering the genetic "architecture" of numerous drug responses and identifying key regulators that control these responses, Ferdig hopes to map new approaches to conquering drug resistant malarial genes.

One paper from the Ferdig lab appeared in the journal PLoS Biology. The second, in collaboration with Tim Anderson at Southwest Biomedical Research Foundation, appeared in PLoS Genetics.


'/>"/>

Contact: Michael Ferdig
ferdig.1@nd.edu
574-631-9973
University of Notre Dame
Source:Eurekalert

Page: 1

Related biology news :

1. U.S. IEEE members to report on Sci-Tech at California newspapers
2. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
3. Light pollution offers new global measure of coral reef health
4. Ripple effect: Water snails offer new propulsion possibilities
5. Commercial aquatic plants offer cost-effective method for treating wastewater
6. Advance offers revolution in food safety testing
7. Worm genome offers clues to evolution of parasitism
8. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
9. Combining advanced medical and information technologies offers pathway to lower health care costs
10. New study offers solution to global fisheries collapse
11. Giant grass offers clues to growing corn in cooler climes, researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... the National Institute of Standards and Technology (NIST) ... more effectively, they often prove that necessity is ... case recently for M. Lorna De Leoz and ... specialization of glycomics. Glycomics is the study of ... are attached to proteins and lipids and influence ...
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... the Max Planck Institute for Medical Research in Heidelberg, ... photosynthesis, the process by which the Earth first gained ... which is therefore crucial for all higher forms of ... first direct visualization of a crucial event in the ... protein complex, photosystem II, splits water into hydrogen and ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2A first direct glimpse of photosynthesis in action 2
... major world religions can play a key role in preserving ... the Swedish University of Agricultural Sciences (SLU), among others, indicates ... a change, they would be ideally positioned to do so. ... distributed around the world and how they overlap areas that ...
... researchers today released seven technical reports that together ... fracturing, the controversial natural gas and oil extraction ... totaling nearly 200 pages, examine seven critical topics ... Michigan, with an emphasis on high-volume methods: technology, ...
... wastewater managers are missing substantial opportunities to save energy ... 4) by Water in the West, a research center ... A Literature Review," also identifies the amount of water ... and coal, and to generate electricity. , The report ...
Cached Biology News:Religious leaders can be key to biological diversity 2U-M technical reports examine hydraulic fracturing in Michigan 2U-M technical reports examine hydraulic fracturing in Michigan 3U-M technical reports examine hydraulic fracturing in Michigan 4U-M technical reports examine hydraulic fracturing in Michigan 5U-M technical reports examine hydraulic fracturing in Michigan 6U-M technical reports examine hydraulic fracturing in Michigan 7Report reveals missed opportunities to save water and energy 2
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
(Date:7/10/2014)... , July 10, 2014  Franciscan St. ... of capnography for respiratory monitoring outside the ... healthcare leaders in embracing state-of-the-art patient safety ... patients are breathing and can alert medical ... measuring the amount of carbon dioxide the ...
(Date:7/10/2014)... OAKS, Calif., July 10, 2014   Ceres, Inc ... and seed company, announced today financial results for the ... update on its business. Ceres reported that ... in product performance this growing season in Brazil, which ... affected the company,s sorghum evaluation areas for part of ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2
... 2010 -- Tomorrow,s television and computer screens could be ... a process developed by a team of researchers from ... Laboratory. The synthesis of a conjugated organic polymer--widely ... diodes, televisions and solar cells--could mean more efficient, cheaper ...
... , SAN DIEGO , July 19 "Amira ... with GlaxoSmithKline, has achieved two clinical development milestones." , ... These milestones are related to the successful progression of the program ... inhibitor in patients suffering from asthma.   , ...
... July 16 Talecris Biotherapeutics Holdings Corp. (Nasdaq: TLCR ) will issue ... 2010 . Due to the pending merger with Grifols, S.A., Talecris will not be ... , , ... , , , ...
Cached Biology Technology:Polymer synthesis could aid future electronics 2Amira Pharmaceuticals Hits Two Development Milestones Related to FLAP Inhibitor Program 2
... acetylcholinesterase (AChE) activity. This is a highly ... non-radioactive and easy to use assay for ... acetylcholine. A series of coupled enzyme reactions ... a change in luminescence. Inhibitors of AChE ...
Rabbit polyclonal to Vitronectin ( Abpromise for all tested applications). Antigen: Full length native Vitronectin (Cow) Entrez Gene ID: 7448 Swiss Protein ID: P04004...
McCoy's 5A Medium. Without Tryptose or Phosphate Broth. Contains Sodium Bicarbonate....
... Exiqons LNA technology enables sensitive, fast and ... intact chromosomes. Short hybridisation time ... cells and chromosome spreads Multiplex capability ... probes Probes available with ...
Biology Products: