Navigation Links
New papers offer insights into process of malarial drug resistance
Date:11/26/2008

Malaria, one of the oldest diseases known to man, has shown no signs of slowing down as it ages. More than 1 million children die from malaria in sub-Saharan Africa each year, and in areas along the Thailand/Cambodian border multiple drug-resistant strains of the disease are becoming commonplace.

With the previously mainstay antimalarial drug chloroquine nearly ineffective due to drug resistance and traditional public health approaches such as mosquito netting offering uneven results, two new papers by University of Notre Dame biologist Michael Ferdig suggest that the means of combating this old foe may lie in the new tools of genomics and bioinformatics.

In the papers, Ferdig points out that development of the malaria parasite Plasmodium falciparum in the blood is driven by a number of different genes expressed at different times and at different levels. Exactly what influences such transcriptional changes remains elusive, particularly in regard to important phenotypes like drug resistance.

Ferdig and his collaborators combined classical genetics with cutting-edge genomic methods to illuminate previously unrecognized transcriptional complexity and variation in Plasmodium falciparum and possibly master regulators within large copy number variants that contribute to the drug-resistant phenomena in malaria parasites.

By uncovering the genetic "architecture" of numerous drug responses and identifying key regulators that control these responses, Ferdig hopes to map new approaches to conquering drug resistant malarial genes.

One paper from the Ferdig lab appeared in the journal PLoS Biology. The second, in collaboration with Tim Anderson at Southwest Biomedical Research Foundation, appeared in PLoS Genetics.


'/>"/>

Contact: Michael Ferdig
ferdig.1@nd.edu
574-631-9973
University of Notre Dame
Source:Eurekalert

Page: 1

Related biology news :

1. U.S. IEEE members to report on Sci-Tech at California newspapers
2. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
3. Light pollution offers new global measure of coral reef health
4. Ripple effect: Water snails offer new propulsion possibilities
5. Commercial aquatic plants offer cost-effective method for treating wastewater
6. Advance offers revolution in food safety testing
7. Worm genome offers clues to evolution of parasitism
8. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
9. Combining advanced medical and information technologies offers pathway to lower health care costs
10. New study offers solution to global fisheries collapse
11. Giant grass offers clues to growing corn in cooler climes, researchers report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2015)... 2015 Research and ... of the  "Genetic Testing Market Outlook 2018" ... , ,A recent report, Genetic Testing Market ... the current and future genetic testing market. ... working principles and types are covered in ...
(Date:5/14/2015)... , May 14, 2015 Research and Markets ... of the "Fingerprint Sensors Market in Smart Mobile ... This report believes that 2014 was a watershed year ... Apple,s introduction of ,Apple Pay,. Apple gave fingerprint sensors ... mobile payment service. Fingerprint sensors are a must-have feature ...
(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
Breaking Biology News(10 mins):Global Genetic Testing Market Outlook 2018 2Global Smart Mobile Devices Fingerprint Sensors Market 2015-2019: Key Vendors are Authentec, Validity Sensors, Fingerprint Cards, Next Biometrics Group. IDEX, and Qualcomm 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... imitate sounds that are not typical of their species, ... in a non-primate terrestrial mammal. The discovery, reported in ... is important for maintaining individual social relationships among animals ... whales, some birds, and bats. , Researchers from the ...
... of Medicine have discovered the cause of a deadly ... A constriction of the blood vessels in the brain, ... a massive brain bleed known as hemorrhagic stroke. Sixty ... vasospasm, and 40 percent of them die from it. ...
... prospect of using nanoparticles in biomedical applications and consumer ... the miniscule materials. Scientists at the University of Michigan ... of nanoparticles damage cell membranes—enough to cause cell death ... , "If you're inventing these sorts of materials, you ...
Cached Biology News:Elephants imitate sounds as a form of social communication 2Researchers discover molecule that causes secondary stroke 2Probing The Promise And Perils Of Nanoparticles 2Probing The Promise And Perils Of Nanoparticles 3
(Date:5/28/2015)... , May 27, 2015 Research and ... Jain PharmaBiotech,s new report "Neuroprotection - Drugs, ... This report describes the role of neuroprotection ... of the nervous system as well as in ... of the underlying mechanisms of damage to neural ...
(Date:5/28/2015)... Dallas, TX (PRWEB) May 28, 2015 ... trade association serving and representing the life sciences ... first Board of Directors meeting at The Foundry ... meeting of the organization brought together a broad ... region, and underscored the organization's early successes in ...
(Date:5/28/2015)... May 28, 2015 CD-adapco, the ... Engineering software, announced today it is joining the ... will provide state-of-the-art engineering simulation tools for analyzing ... expertise and experiences in analyzing particle flow that ... and advance the understanding of flow modeling solutions. ...
(Date:5/28/2015)... Atlanta, Georgia (PRWEB) May 28, 2015 ... Ridge National Laboratory (Oak Ridge, TN) recently ... strength of 3D printing plastic resins using nanocellulose, ... well-known constraint of 3D printing is the limited ... resins provide inadequate mechanical strength to printed parts ...
Breaking Biology Technology:Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 2Global Neuroprotection Market Report 2015-2024 - Drugs, Markets and Companies 3BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3
... International, a leading Clinical Research Organization, announces it will ... for Pharmacoeconomics and Outcomes Research (ISPOR), May 18-20 in ... group will be present in Booth 19 at ISPOR ... group supports global and regional Post-Approval studies. With ...
... SAN RAMON, Calif., May 15 Odyssey Thera, ... with leading Japanese pharmaceutical company Mitsubishi Tanabe Pharma ... drug candidates from a number of Mitsubishi Tanabe ... Japanese patent number JP 4262778, entitled "Protein fragment ...
... commercial launch of the Cryptonite™ HV Filter Module for Cryptosporidium ... ... Atlanta, GA (PRWEB) May 15, 2009 -- ElutraSep, ... Filter Module for Cryptosporidium and Giardia testing. www.elutrasep.com/app-Cryptosporidium.asp ...
Cached Biology Technology:PRA International Participating in Pharmacoeconomics and Outcomes Research Conference 2Odyssey Thera Announces Collaboration With Mitsubishi Tanabe Pharma Corporation, and Issuance of Core Patent in Japan 2ElutraSep Inc. Announces the Launch of the Cryptonite™ HV Filter Module for Cryptosporidium and Giardia Testing 2