Navigation Links
New paper sheds light on bacterial cell wall recycling
Date:9/8/2008

A new paper by a team of researchers led by Shahriar Mobashery, Navari Family Professor of Life Sciences at the University of Notre Dame, provides important new insights into the process by which bacteria recycle their cell wall.

The cell wall is a critically important entity for bacteria and essential for their survival. It is a rigid entity encasing the bacterium, and antibiotics are designed to interfere with disease processes by affecting its maturation. The function of antibiotics is to impair the cell wall, leading to bacterial death.

Scientists have determined that during bacterial growth a substantial amount of the parental cell wall is recycled. Although the recycling process has been known, its intricacies have not been well understood to date.

Mobashery's team synthesized pieces of the cell wall of the bacterium Escherichia coli in his laboratory and was able to use the synthetic wall components to observe the chemical reactions that take place during the recycling process.

The researchers found that a member of the lytic transglycosylases family of enzymes known as M1tB performed the requisite cell wall fragmentation on the synthetic sample of the cell wall from their laboratory. They also were able to measure the rate of the transformation by M1tB, determining that 14,000 pieces of the cell wall are processed by each molecule of M1tB in one bacterial generation.

The product of the M1tB reaction on the cell wall is the entity that initiates the recycling event, but when it diffuses out of the bacterium, it causes the onset of the pro-inflammatory events associated with bacterial infections.


'/>"/>

Contact: Shahriar Mobashery
mobashery@nd.edu
574-631-2933
University of Notre Dame
Source:Eurekalert

Page: 1

Related biology news :

1. Beyond batteries: Storing power in a sheet of paper
2. Coal and black liquor can produce energy from papermaking
3. New paper examines dams effects on California salmon
4. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
5. RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos
6. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
7. New whitepaper offers options for university implementation of NIH policy
8. For the paper trail of life on Mars or other planets, find cellulose
9. Nature paper describes technique for extracting hierarchical structure of networks
10. A gentle touch for better control, a quantum mechanical con, and milestone PRL papers
11. U.S. IEEE members to report on Sci-Tech at California newspapers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , April 28, 2016 Infosys ... (NYSE: INFY ), and Samsung SDS, a global ... that will provide end customers with a more secure, fast ...      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... but it also plays a fundamental part in enabling and ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/19/2016)... 20, 2016 The new GEZE ... compact web-based "all-in-one" system solution for all door components. ... or the door interface with integration authorization management system, ... systems. The minimal dimensions of the access control and ... building installations offer considerable freedom of design with regard ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
(Date:6/23/2016)... Connecticut (PRWEB) , ... June 23, 2016 , ... ... introduce a new line of intelligent tools designed, tuned and optimized exclusively for ... September 12–17 in Chicago. The result of a collaboration among several companies with ...
(Date:6/22/2016)... 22, 2016 Research and Markets has announced ... report to their offering. ... from $29.3 billion in 2013. The market is expected to grow ... 2015 to 2020, increasing from $50.6 billion in 2015 to $96.6 ... during the forecast period (2015 to 2020) are discussed. As well, ...
(Date:6/22/2016)... --  ViaCyte, Inc. , a privately-held regenerative medicine company ... for the treatment of diabetes in clinical-stage development, today ... 2016, the Global Stem Cell Event, is taking place ... Francisco.    ... Focus Session: Tools for Basic and Applied Stem Cell ...
Breaking Biology Technology: