Navigation Links
New paper describes how DNA avoids damage from UV light
Date:7/31/2014

BOZEMAN, Mont. In the same week that the U.S. surgeon general issued a 101-page report about the dangers of skin cancer, researchers at Montana State University published a paper breaking new ground on how DNA the genetic code in every cell responds when exposed to ultraviolet (UV) light.

The findings advance fundamental understanding of DNA damage by the UV rays found in sunlight. This damage can lead to skin cancer, aging and some degenerative eye diseases.

"Our paper advances foundational knowledge about how DNA responds to UV radiation. In our experiments, we observe the earliest events immediately after DNA is energized by UV radiation. These events determine whether or not DNA is damaged," said one of the paper's co-authors, Bern Kohler, an MSU professor in the Department of Chemistry and Biochemistry.

DNA is built like a staircase and carries genetic instructions that are unique to each person. It's very hardy and generally able to stand up to ultraviolet rays, but UV rays sometimes cause mutations. UV exposure is a major cause of skin cancer, and while there are nearly 5 million cases of skin cancer each year in the U.S. alone and 9,000 related deaths the numbers would be far worse if DNA were more easily damaged.

"UV is actually very damaging, yet our DNA is damaged less than expected," Kohler said. "In the early evolution of life on Earth when there was no ozone layer, the amount of UV would have been far higher and yet life, and the DNA that is central to life, survived. We've been trying to understand the molecular mechanisms that make DNA resist UV damage."

In a paper published July 28 in the online version of the scientific journal, "Proceedings of the National Academy of Sciences" (PNAS), Kohler and his colleagues from MSU, Utah and Italy describe how DNA has a super-fast way of shrugging off the UV threat.

Too quick for the eye to see, UV light causes an electron to be tr
'/>"/>

Contact: Evelyn Boswell
evelynb@montana.edu
406-994-5135
Montana State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New paper amplifies hypothesis on human languages deep origins
2. Rising star uses paper to tackle food-borne diseases
3. Researchers receive top honors for ecology paper
4. Researchers design trees that make it easier to produce paper
5. Nano-paper filter removes viruses
6. Telecoupling paper honored as 2013s best
7. Analytical and Bioanalytical Chemistry Best Paper Award to Sherrie Elzey and De-Hao Tsai
8. Paper offers insights into network that plays crucial role in cell function and disease
9. Two papers unraveled the mystery of sex determination and benthic adaptation of the flatfish
10. The Protein Society announces the selection of 2 Protein Science Best Paper speakers
11. Paper predicts a future without carnivores would be truly scary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... you want your doctor to know what goes wrong with ... good idea to know what "normal" actually is. That,s where ... of the FASEB Journal comes in. ... transcriptomea key set of molecules that can help scientists "see" ... time. What,s more, they found never-before-detected gene activity and that ...
(Date:9/30/2014)... threats in today,s ocean. From overfishing and pollution ... ecosystems are disappearing at unprecedented rates around the ... surrounding the island of Moorea in French Polynesia ... coral guard-crabs. New research from the National Museum ... McKeon and the museum,s predoctoral fellow Jenna Moore ...
(Date:9/29/2014)... that the exposure to tar tended to be lower ... Similarly, exposure to nicotine tended to be lower. ... cigarette in several countries around the world. Previous studies ... in the smoke of these cigarettes are lower than ... chemicals in the smoke are not necessarily linked to ...
Breaking Biology News(10 mins):Scientists identify which genes are active in muscles of men and women 2Smithsonian scientists discover coral's best defender against an army of sea stars 2Slim cigarette smokers not exposed to more harmful chemicals 2
... of Salamanca and another from Yale University have shown that ... beershebensis , a lizard species from the Negev Desert in ... less and catch less mobile and different prey if they ... predicted this result, but until now there had been very ...
... National Primate Research Center, Emory University, have successfully ... step toward unlocking the genetic secrets of pair ... will enable scientists to perform a host of ... mechanisms of social bonding and other complex social ...
... is available in German . , Brown adipose ... mitochondria, miniature power stations which among other things can ,burn, ... that of a battery, which then provides energy for cellular processes. ... They go full steam ahead all the time. The energy released ...
Cached Biology News:Lizards change their diet to avoid predators 2Yerkes researchers create first transgenic prairie voles 2Brown fat cells make 'spare tires' shrink 2
(Date:9/30/2014)... September 30, 2014 Lyme Research ... of Lyme disease research at universities, today announced the ... on the identification, treatment and cure for Lyme and ... received the most applications in its history—over 20 grant ... “While we were pleased to receive so many solid ...
(Date:9/30/2014)... September 30, 2014 On September 11, Pharma ... Sherley in anticipation of a session that he will lead ... Summit,” scheduled for February 17-18, 2015 in London. In ... IQ asked Dr. Sherley to respond to several questions on ... challenges to evaluating stem cell toxicity, and future trends in ...
(Date:9/30/2014)... Ontario, Canada (PRWEB) September 30, 2014 Back ... based on 500 square feet. per employee, which included space ... world back then.” says Jeff Howell, partner at Nidea ... advisory firm in Toronto. “By the year 2000, however, ... are now seeing that number come down to 175 to ...
(Date:9/29/2014)... at the forefront of diagnostics today, with imaging ... tomography), scanning, and NMR (nuclear magnetic resonance) increasing ... problems of image resolution and quality still limit ... tissue. A solution is hyperpolarization, which involves injecting ... quality by following the distribution and fate of ...
Breaking Biology Technology:Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 2Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 3Adult Stem Cell Technology Center, LLC Director James L. Sherley Discusses Stem Cell Toxicology 4ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3
... 2011 Clinicians now have a new tool to help ... -- one of the most common sexually transmitted infections in ... BD (Becton, Dickinson and Company), announced today that it received ... first fully automated molecular tests to detect and differentiate HSV ...
... 2011 The Japanese nuclear crisis has caused a ... not only in Japan, but as far away as ... iodide does not provide generalized radiation protection because it ... bombarded with orders as the radiation hysteria mounts. ...
... (Nasdaq: VRML ) – Vermillion, a molecular ... coverage March 23, 2011 on Vermillion. This ... at Stephens by contacting, Scott Gleason at scott.gleason@stephens.com ... Vermillion, Inc. is dedicated to the discovery, development and ...
Cached Biology Technology:BD Diagnostics Receives FDA Clearance for First Fully Automated Molecular Assays for HSV1 and HSV2 from Clinician-Collected External Anogenital Lesion Specimens 2Shortages of Potassium Iodide as Radiation Panic Drives Demand 2Stephens Initiates Coverage on Vermillion 2Stephens Initiates Coverage on Vermillion 3
... Motic's B3 series of microscopes offer ... microscope required for laboratory work. Equipped with ... Super Contrast (ASC) objectives. The B3 is ... The Siedentopf binocular tube eliminates the need ...
... SYBR Green II RNA gel ... gel stain that has bright fluorescence when ... gels, making it ideal for use with ... scanners or standard UV transilluminators. A 500 ...
... SYBR Green II RNA gel stain ... has bright fluorescence when bound to RNA and ... use with either formaldehyde/agarose or polyacrylamide gels using ... stains 100 minigels. A 500 µL unit size ...
... Glutathion-S-transferases (GST) are a group ... the detoxification processes. The GSTs are ... Pi, Teta and microsomal. The classes ... and s Sample Size: ...
Biology Products: