Navigation Links
New organization brings together top researchers to sequence genomes of invertebrates
Date:12/13/2013

FORT LAUDERDALE-DAVIE, Fla. Pop Quiz: what creatures make up more than 70% of the approximately 1.9 million described species on earth and have long served as model organisms in many areas of biology? If you guessed invertebrates, you're right!

To begin exploring this question, a new cooperative consortium called the Global Invertebrate Genomics Alliance (GIGA) was formed and held its inaugural workshop at Nova Southeastern University's (NSU) Oceanographic Center in March 2013.

Jose Lopez, Ph.D., a professor at NSU's Oceanographic Center, organized this workshop of expert invertebrate scientists to discuss the plausibility of and long-term strategies for sequencing the whole genomes of multiple, targeted (non-insect, non-nematode) invertebrate organisms.

"There's so much more we can learn from these animals if we come together to focus and coordinate our research efforts," said Lopez. "GIGA allows us to work collaboratively, as we discover new and exciting details of invertebrate genomics."

For years, these creatures have been a staple in research; they include sea urchins for developmental/cancer cell biology; the mollusks Aplysia and Loligo for neurobiology research; Drosophila fruit flies for genetics, and the nematode worm C. elegans for cell line maturation, development and genetics. (Studies using all of these have received Nobel Prizes.)

Invertebrates display many unique and outlandish traits among animals, such as:

  • Some invertebrates are the longest-living animals on the planet, including Lamellibrachia tube worms (~250 years), Quahog clams Arctica islandica (maximum reported age 507 years), black corals (estimated 2,000 years) and the immortal Hydra;
  • Tartigrades ("water bears") can survive extreme temperatures (-150C to 150C), ionizing solar and galactic radiation, and even interplanetary vacuum;
  • Octopuses not only have 8 arms, but also 3 hearts, and highly developed brains and visual systems; and,
  • Sponges represent the most ancient lineage of animals and, together with corals, produce the largest number of chemical "lead" molecular structures for discovery of novel pharmaceuticals.

Given all that invertebrates can teach us about biodiversity, the question has arisen: are these unique features encoded within the DNA "genomes" (the complete hereditary material) of invertebrate organisms?

The overarching goal of GIGA is to provide a network of diverse scientists who will promote comparative genomics and bioinformatics research on non-insect/non-nematode invertebrates. GIGA was partially inspired by the Genome 10K project, initiated by NSU's affiliate professor Stephen J. O'Brien, Ph.D., and colleagues to sequence genomes from 10,000 vertebrate animals.

Workshop participants came from the U.S., China, and Europe and included more than 40 experts in invertebrate biology, genomics and systematics from several universities and institutions, such as the Smithsonian and Scripps Oceanographic, and biotech industries (Life Technologies, PacBio and BioNanoGenomics) as well as NSU graduate and undergraduate students. In-depth discussions to develop the consortium's framework were hashed out in breakout groups: which specific genomes to prioritize for sequencing, what DNA or RNA sequencing platforms are optimal, standards for collections and sample preparations, and where to specify a particular invertebrate taxon's place on the evolutionary Tree of Life. Also discussed were nascent policies on data submittal, access and sharing within the GIGA consortium.

Primary funding for the workshop to kick-start GIGA was generously awarded by the American Genetic Association, publisher of Journal of Heredity. The momentum of the workshop has carried on, leading to the creation of an NSU-hosted Website (GIGA.nova.edu) more international collaborations (i.e. the GIGA symposium at next summer's Society for Molecular Biology and Evolution - SMBE in Puerto Rico) and the white paper published in the current issue of Journal of Heredity. This article further showcases GIGA's main goals, ongoing projects, and recommended experimental standards and policies.

Dr. Lopez and colleagues summarized the mission of the consortium: "GIGA views our ongoing efforts as opportunities for those who have devoted their lives to the study of particular taxa to merge their deeper insights of the evolutionary history of their organisms into a modern genomics context."


'/>"/>

Contact: Joe Donzelli
jdonzelli@nova.edu
954-262-2159
Nova Southeastern University
Source:Eurekalert  

Related biology news :

1. UMass Amherst physics professor wins grant to study organization inside cells space
2. Join Leading Organizations at Biodetection Technologies 2013 in Alexandria, VA from June 18-19, 2013
3. Governor Corbett Presented 2013 Biotechnology Industry Organization Governor of the Year Award
4. Federal Government Organization achieves cleaner and faster Clinical Study Data using Tablet PCs from TabletKiosk
5. Japanese research organizations contribute to Human Brain Project
6. New look at cell membrane reveals surprising organization
7. Pan-European organizations call for an advanced understanding of the human brain
8. Algae Biomass Organization hails new UCSD study showing saltwater algae viable for biofuels
9. Major advances in understanding the regulation and organization of the human genome
10. First International Bioenergy Conference brings together world-leading experts
11. New Ocean Sensing and Monitoring brings tutorial approach to latest advances
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New organization brings together top researchers to sequence genomes of invertebrates
(Date:11/15/2016)... , Nov. 15, 2016  Synthetic Biologics, Inc. ... therapeutics focused on the gut microbiome, today announced ... 25,000,000 shares of its common stock and warrants ... at a price to the public of $1.00 ... Synthetic Biologics from the offering, excluding the proceeds, ...
(Date:6/27/2016)... June 27, 2016 Research and Markets has ... 2016-2020" report to their offering. ... America to grow at a CAGR of 12.28% during ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
(Date:6/21/2016)... 2016 NuData Security announced today that Randy ... principal product architect and that Jon Cunningham ... development. Both will report directly to Christopher ... reflect NuData,s strategic growth in its product and ... demand and customer focus values. ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... , December 5, 2016 The ... with almost $108 billion of revenue and some $890 ... were spent on global biopharmaceuticals, and this figure is ... Stock-Callers.com has lined up these four equities for assessment: ... Pharmaceuticals Inc. (NASDAQ: ACAD ), Acorda Therapeutics ...
(Date:12/2/2016)... ... December 02, 2016 , ... In anticipation of AxioMed’s exclusive ... production, company President, Jake Lubinski will be traveling to Switzerland from December 5-10. ... Bern, Lucerne, and Zurich to discuss the benefits of a viscoelastic disc. AxioMed ...
(Date:12/2/2016)... Research and Markets has announced the addition of Jain ... to their offering. ... , An increasing ... anticipated. Nanotechnology will be applied at all stages of drug ... in clinical trials. Many of the assays based on nanobiotechnology ...
(Date:12/2/2016)... York, NY (PRWEB) , ... December 01, 2016 , ... ... event is expanding to three days and will take place on February 1-3, 2017 ... (GSK) and Dr James Gulley (NCI), the program provides a unique 360-degree approach, which ...
Breaking Biology Technology: